Lin Zhang

faculty photo
Harry Fields Research Associate Professor
Department: Obstetrics and Gynecology

Contact information
University of Pennsylvania School of Medicine
421 Curie Blvd, Biomedical Research Building II/III
Lab: 1233~1237; Office: 1207
linzhang@mail.med.upenn.edu
Philadelphia, PA 19104
Office: 215-573-4780
Fax: 215-573-7627
Lab: 215-573-7947
Education:
MD
China Medical University, 1996.
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Description of Research Expertise

Targeted therapy for ovarian and breast cancers

Cancer genome and epigenome

Non-coding RNAs

Selected Publications

Yang Lu, Zhang Youyou, Shan Weiwei, Hu Zhongyi, Yuan Jiao, Pi Jingjiang, Wang Yueying, Fan Lingling, Tang Zhaoqing, Li Chunsheng, Hu Xiaowen, Tanyi Janos L, Fan Yi, Huang Qihong, Montone Kathleen, Dang Chi V, Zhang Lin: Repression of BET activity sensitizes homologous recombination-proficient cancers to PARP inhibition. Science Translational Medicine 9(400), Jul 2017.

Zhang Y, He Q, HU Z, Feng Y, Fan L, Tang Z, Yuan J, Shan W, Li C, Hu X, Tanyi JL, Fan Y, Huang Q, Montone K, Dang CV, Zhang L: Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer. Nat Struct Mol Biol Page: 23(6):522-30. Apr 2016.

Yan X, Hu Z, Feng Yi, Hu X, Yuan J, Zhao SD, Zhang Y, Yang L, Shan W, He Q, Fan L, Kandalaft LE, Tanyi JL, Li C, Yuan C-X, Zhang D, Yuan H, Hua K, Lu Y, Katsaros D, Huang Q, Montone K, Fan Y, Coukos G, Boyd J, Sood AK, Rebbeck T, Mills GB, Dang CV, Zhang L: Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers. Cancer Cell 28(4): 529-40, Oct 2015.

Hu X, Feng Y, Zhang D, Zhao SD, Hu Z, Greshock J, Zhang Y, Yang L, Zhong X, Wang L-P, Jean S, Li C, Huang Q, Katsaros D, Montone KT, Tanyi JL, Lu Y, Boyd J, Nathanson KL, Li H, Mills GB, Zhang L: A Functional Genomic Approach Identifies FAL1 as an Oncogenic Long Noncoding RNA that Associates with BMI1 and Represses p21 Expression in Cancer. Cancer Cell 26(3): 344-57, Sep 2014.

Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang L-P, Gimotty PA, Gilks CB, Lal P, Zhang L, Coukos G: Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature 475(7355): 226-30, Jul 2011.

Zhang L, Volinia S, Bonome T, Calin GA, Greshock J, Yang N, Liu C-G, Giannakakis A, Alexiou P, Hasegawa K, Johnstone CN, Megraw MS, Adams S, Lassus H, Huang J, Kaur S, Liang S, Sethupathy P, Leminen A, Simossis Victor A, Sandaltzopoulos R, Naomoto Y, Katsaros D, Gimotty PA, DeMichele A, Huang Q, B├╝tzow R, Rustgi A, Weber BL, Birrer MJ, Hatzigeorgiou AG, Croce CM, Coukos G: Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer. Proceed Nat Acad Sciences of USA 105(19): 7004-9, May 2008.

Zhang L, Huang J, Yang N, Greshock J, Megraw MS, Giannakakis A, Liang S, Naylor TL, Barchetti A, Ward MR, Yao G, Medina A, O'brien-Jenkins A, Katsaros D, Hatzigeorgiou A, Gimotty PA, Weber BL, Coukos G: microRNAs exhibit high frequency genomic alterations in human cancer. Proceed Nat Acad Sciences of USA 103(24): 9136-41, Jun 2006.

Zhang L, Conejo-Garcia JR, Katsaros D, Gimotty PA, Massobrio M, Regnani G, Makrigiannakis A, Gray H, Schlienger K, Liebman M N, Rubin SC, Coukos G: Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. New England Journal of Medicine 348(3): 203-13, Jan 2003.

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Last updated: 08/02/2017
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