Michael Chorny

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Research Assistant Professor of Pediatrics
Associate Director, Center for Targeted Therapeutics & Translational Nanomedicine of the ITMAT (Institute of Translational Medicine & Therapeutics)
Department: Pediatrics

Contact information
The Abramson Pediatric Research Center, Suite 702G
The Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-590-3063
BPharm (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 1996.
MS (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 1997.
PhD (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 2004.
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Description of Itmat Expertise

Design of drug, gene, protein and cell delivery systems
Magnetically targeted therapy of arterial restenosis
Nanocarrier-based site-specific gene delivery methods

Selected Publications

I.S. Alferiev, R. Iyer, J.L. Croucher, R.F. Adamo, K. Zhang, J.L. Mangino, V. Kolla, I. Fishbein, G.M. Brodeur, R.J. Levy, M. Chorny: Nanoparticle-mediated delivery of a rapidly activatable prodrug of SN-38 for neuroblastoma therapy. Biomaterials 51: 22-9, May 2015.

R. Iyer*, J.L. Croucher*, M. Chorny*, J.L. Mangino, I.S. Alferiev, R.J. Levy, V. Kolla, G.M. Brodeur: Nanoparticle delivery of an SN38 conjugate is more effective than irinotecan in a mouse model of neuroblastoma. Cancer Letters In press, 2015 Notes: (* equal contribution).

P.C. Naha, A. Al Zaki, E. Hecht, M. Chorny, P. Chhour, E. Blankemeyer, D.M. Yates, W.R.T. Witschey, H.I. Litt, A. Tsourkas, D.P. Cormode: Dextran coated bismuth-iron oxide nanohybrid contrast agents for computed tomography and magnetic resonance imaging. Journal of Materials Chemistry. B, Materials for Biology and Medicine 2: 8239-8248, Oct 2014.

I. Fishbein, S.P. Forbes, R.F. Adamo, M. Chorny, R.J. Levy, I.S. Alferiev: Vascular gene transfer from metallic stent surfaces using adenoviral vectors tethered through hydrolysable cross-linkers. Journal of Visualized Experiments 90: e51653, Aug 2014.

M.D. Howard, E.D. Hood, C.F. Greineder, I.S. Alferiev, M. Chorny, V. Muzykantov: Targeting to endothelial cells augments the protective effect of novel dual bioactive antioxidant/anti-inflammatory nanoparticles. Molecular Pharmaceutics 11(7): 2262-70, Jul 2014.

E.D. Hood, M. Chorny, C.F. Greineder, I.S. Alferiev, R.J. Levy, V.R. Muzykantov: Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation. Biomaterials 35(11): 3708-15, Apr 2014.

J.E. Tengood, I.S. Alferiev, K. Zhang, I. Fishbein, R.J. Levy, M. Chorny: Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media. Proceedings of the National Academy of Sciences of the United States of America 111(11): 4245–50, Mar 2014.

I. Fishbein, S.P. Forbes, M. Chorny, J.M. Connolly, R.F. Adamo, R.A. Corrales, I.S.Alferiev, R.J. Levy : Adenoviral vector tethering to metal surfaces via hydrolyzable cross-linkers for the modulation of vector release and transduction. Biomaterials 34(28): 6938-48, Sep 2013.

M. Chorny, I. Fishbein, J.E. Tengood, R.F. Adamo, I.S. Alferiev, R.J. Levy: Site-specific gene delivery to stented arteries using magnetically guided zinc oleate-based nanoparticles loaded with adenoviral vectors. The FASEB Journal 27: 2198-206, Jun 2013.

E. Branchetti, R. Sainger, P. Poggio, J.B. Grau, J. Patterson-Fortin, J.E. Bavaria, M. Chorny, E. Lai, R.C. Gorman, R.J. Levy, G. Ferrari: Antioxidant Enzymes Reduce DNA Damage and Early Activation of Valvular Interstitial Cells in Aortic Valve Sclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 33(2): e66-74, Feb 2013.

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Last updated: 03/20/2015
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