Michael Chorny

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Research Assistant Professor of Pediatrics
Associate Director, Center for Targeted Therapeutics & Translational Nanomedicine of the ITMAT (Institute of Translational Medicine & Therapeutics)
Department: Pediatrics

Contact information
The Abramson Pediatric Research Center, Suite 702G
The Children's Hospital of Philadelphia
3615 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-590-3063
Education:
BPharm (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 1996.
MS (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 1997.
PhD (Pharmaceutical sciences)
The Hebrew University of Jerusalem, Israel, 2004.
Permanent link
 

Description of Itmat Expertise

targeted drug, gene and cell therapy
magnetically targeted systems
viral and non-viral gene delivery methods

Selected Publications

E.D. Hood, M. Chorny, C.F. Greineder, I.S. Alferiev, .J. Levy, V.R. Muzykantov: Endothelial targeting of nanocarriers loaded with antioxidant enzymes for protection against vascular oxidative stress and inflammation Biomaterials 35(11): 3708-3715, Apr 2014.

J.E. Tengood, I.S. Alferiev, K. Zhang, I. Fishbein, R.J. Levy, M. Chorny: Real-time analysis of composite magnetic nanoparticle disassembly in vascular cells and biomimetic media. Proceedings of the National Academy of Sciences of the United States of America 111(11): 4245–4250, March 2014.

I. Fishbein, S.P. Forbes, M. Chorny, J.M. Connolly, R.F. Adamo, R.A. Corrales, I.S.Alferiev, R.J. Levy : Adenoviral vector tethering to metal surfaces via hydrolyzable cross-linkers for the modulation of vector release and transduction. Biomaterials 34(28): 6938-48, Sep 2013.

M. Chorny, I. Fishbein, J.E. Tengood, R.F. Adamo, I.S. Alferiev, R.J. Levy: Site-specific gene delivery to stented arteries using magnetically guided zinc oleate-based nanoparticles loaded with adenoviral vectors. The FASEB Journal 27: 2198-2206, Jun 2013.

E. Branchetti, R. Sainger, P. Poggio, J.B. Grau, J. Patterson-Fortin, J.E. Bavaria, M. Chorny, E. Lai, R.C. Gorman, R.J. Levy, G. Ferrari: Antioxidant Enzymes Reduce DNA Damage and Early Activation of Valvular Interstitial Cells in Aortic Valve Sclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology 33(2): e66-74, Feb 2013.

S.P. Forbes, I.S. Alferiev, M. Chorny, R.F. Adamo, R.J. Levy, I. Fishbein: Modulation of NO and ROS production by AdiNOS transduced vascular cells through supplementation with L-Arg and BH4: Implications for gene therapy of restenosis. Atherosclerosis 230: 23-32, 2013.

M. Chorny, I.S. Alferiev, I. Fishbein, J.E. Tengood, Z. Folchman-Wagner, S.P. Forbes, R.J. Levy: Formulation and in vitro characterization of composite biodegradable magnetic nanoparticles for magnetically guided cell delivery. Pharmaceutical Research 29(5): 1232-1241, May 2012.

M. Chorny*, E. Hood*, R.J. Levy, V.R. Muzykantov : Endothelial delivery of antioxidant enzymes loaded into non-polymeric magnetic nanoparticles. Journal of Controlled Release 146(1): 144-51, Aug 2010.

M. Chorny*, I. Fishbein*, B.B. Yellen, I.S. Alferiev, M. Bakay, S. Ganta, R. Adamo, M. Amiji, G. Friedman, R.J. Levy : Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields. Proceedings of the National Academy of Sciences of the United States of America 107(18): 8346-51, May 2010.

M. Chorny, I. Fishbein, I.S. Alferiev, R.J. Levy: Magnetically responsive biodegradable nanoparticles enhance adenoviral gene transfer in cultured smooth muscle and endothelial cells Molecular Pharmaceutics 6(5): 1380-7, Jun 2009.

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Last updated: 04/21/2014
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