Carsten C. Skarke

faculty photo
Research Assistant Professor of Medicine
McNeil Fellow in Translational Medicine, Institute for Translational Medicine and Therapeutics
Department: Medicine

Contact information
Institute for Translational Medicine and Therapeutics (ITMAT)
8036 Maloney Building
3600 Spruce Street
Philadelphia, PA 19104
Office: (215) 746-8330
Fax: (215) 573-8996
Education:
MD (Medicine)
Johannes Gutenberg-University School of Medicine, Mainz, Germany, 1998.
Dr. med. (Pathology)
Johannes Gutenberg-University School of Medicine, Mainz, Germany, 2000.
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Description of Itmat Expertise

Isoprostane Pharmacology – A particular interest is to elucidate the impact of grain alcohol and selected red wines on the formation of isoprostanes as indices of oxidative stress in humans with a dietary background conditioned by omega-3 and omega-6 polyunsaturated fatty acids, i.e. fish oil and safflower oil.

Eicosanoid Pharmacology – The current emphasis here is on studying the clinical pharmacology of a novel cyclooxygenase-2 (COX-2) inhibitor, which recently entered Phase I/II of its drug development program.

Pain / Inflammation – Here the focus is on applying pharmacokinetic, pharmacodynamic and pharmacogenetic tools to study the modulation of the drug response profile for cyclooxygenase (COX) inhibitors and opioid analgesics.

Clinical Research / Regulatory Science – Expertise in designing and implementing FDA-approved randomized-controlled clinical trials is applied to ongoing projects.

Translational Medicine and Therapeutics (TMAT) – A particular interest lies in the translational process of projecting preclinical research across the translational divide with the ultimate goal of developing novel therapeutics.

Selected Publications

G. A. Fitzgerald, G. Yang, G. K. Paschos, X. Liang & C. Skarke: Molecular clocks and the human condition: approaching their characterization in human physiology and disease. Diabetes, Obesity and Metabolism 17(Suppl. 1): 139–142, 2015.

Carsten Skarke, Naji Alamuddin, John A. Lawson, Xuanwen Li, Jane F. Ferguson, Muredach P. Reilly and Garret A. FitzGerald: Bioactive products formed in humans from fish oils. Journal of Lipid Research 2015 Notes: [Featured in an Invited Commentary by Robert C. Murphy. Specialized pro-resolving mediators: Do They Circulate in Plasma? , J. Lipid Res. PMID:26232500; and interviews in Medical Research & Cardiology Today]

Sarapee Hirankarn, Jeffrey S. Barrett, Naji Alamuddin, Garret A. FitzGerald, Carsten Skarke: GCG100649, A Novel Cyclooxygenase-2 Inhibitor, Exhibits a Drug Disposition Profile in Healthy Volunteers Compatible With High Affinity to Carbonic Anhydrase-I/II: Preliminary Dose–Exposure Relationships to Define Clinical Development Strategies. Clinical Pharmacology in Drug Development 2(4): 379–386, July 2013 Notes: DOI: 10.1002/cpdd.47.

Skarke C, Alamuddin N, Lawson JA, Cen L, Propert KJ, FitzGerald GA: Comparative impact on prostanoid biosynthesis of celecoxib and the novel nonsteroidal anti-inflammatory drug CG100649. Clin Pharmacol Ther 91(6): 986-93, June 2012.

Skarke C, Kuczka K, Tausch L, Werz O, Rossmanith T, Barrett JS, Harder S, Holtmeier W, Schwarz JA: Increased bioavailability of 11‑keto-beta-boswellic acid following single oral dose frankincense extract administration after a standardized meal in healthy male volunteers: Modeling and simulation considerations for evaluating drug exposures. J Clin Pharmacol 52(10): 1592-1600, October 2012.

Skarke Carsten, FitzGerald Garret A: Training translators for smart drug discovery. Science Translational Medicine. American Association for the Advancement of Science, 2(26): 26cm12, April 2010.

Skarke C, Reus M, Schmidt R, Grundei I, Schuss P, Geisslinger G, Lötsch J: The cyclooxygenase-2 genetic variant -765G>C does not modulate the effects of celecoxib on prostaglandin E2 production. Clin Pharmacol Ther 80(6): 621-632, December 2006.

Skarke C, Langer M, Jarrar M, Schmidt H, Geisslinger G, Lötsch J: Probenecid interacts with the pharmacokinetics of morphine-6-glucuronide in humans. Anesthesiology 101(6): 1394-1399, December 2004.

Skarke C, Jarrar M, Erb K, Schmidt H, Geisslinger G, Lötsch J : Respiratory and miotic effects of morphine in healthy volunteers when P-glycoprotein is blocked by quinidine. Clin Pharmacol Ther 74(4): 303-311, October 2003.

Skarke C, Jarrar M, Schmidt H, Kauert G, Langer M, Geisslinger G, Lötsch J: Effects of ABCB1 (multi drug resistance transporter) gene mutations on disposition and central nervous effects of loperamide in healthy volunteers. Pharmacogenetics 13(11): 651-660, November 2003.

Skarke C, Darimont J, Schmidt H, Geisslinger G, Lotsch J: Analgesic effects of morphine and morphine-6-glucuronide in a transcutaneous electrical pain model in healthy volunteers. Clin Pharmacol Ther 73(1): 107-121, January 2003.

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Last updated: 09/01/2015
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