Gordon A. Barr

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Associate Professor of Psychology in Anesthesiology and Critical Care
Director, Section of Acute and Chronic Pain Medicine, Dept. Anesth. & CCM, Children's Hospital of Phialdelphia (CHOP)
James Battaglia Endowed Chair of Pediatric Pain Medicine, Dept. Anesth. & CCM, Children’s Hospital of Philadelphia (CHOP)
Department: Anesthesiology and Critical Care

Contact information
Abramson Research Building, Room 716D
Department of Anesthesiology and CCM
Children's Hospital of Philadelphia
Philadelphia, PA 19104
Office: 267-426-9722
Fax: 267-426-8128
Graduate Group Affiliations
Education:
B.A. (Psychology)
Dickinson College, 1969.
M.A.
Carnegie Mellon University, 1971.
Ph.D. (Psychology)
Carnegie Mellon University, 1975.
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Description of Itmat Expertise

My interest is in mechanisms of of stress, pain and recovery from damage to the nervous system from a developmental perspective. I study models of acute and chronic pain, infant-mother attachment, the therapeutic and adverse effects of analgesic, especially opiates, and spinal cord injury and recovery from injury.

Description of Research Expertise

I study transitions during early development. Transitions are important developmental epochs during which time there are substantial changes in how infants/children/adolescents process information. I am particularly interested in mechanisms of of stress, pain and recovery from damage to the nervous system from that developmental perspective. I study models of acute and chronic pain, infant-mother attachment, the therapeutic and adverse effects of analgesics, especially opiates, and spinal cord injury and recovery from injury. Our lab develops and uses sophisticated behavioral assays in young animals in conjunction with a number of anatomical and neurochemical assays to understand mechanisms by which these transitions occur.

Selected Publications

Kabitzke, P.A, Barr, G.A., Chan, T., Harry N. Shair, H.N. & Wiedenmayer, C.P. : Medial Prefrontal Cortex Processes Threatening Stimuli in Juvenile Rats. Neuropsychopharmacology 39(8): 1924-1932, 2014.

Barr, G.A. and Hunter, G.A.: Effects of COX inhibition and LPS on pain in the infant rat. Developmental Neurobiology In press, 2014.

Barr, G.A. and Hunter, D.A.: Interactions between immune and pain processes during early development. Developmental Psychobiology doi: 10.1002/dev.21229, 2014.

Sarro, E.C., Sullivan, R.M. and Barr, G.A.: Unpredictable neonatal stress enhances adult anxiety and alters amygdala gene expression related to serotonin and GABA. Neuroscience 258: 147-161, 2014.

Roth, T.L., Barr, G.A., Lewis, M.J. and Sullivan, R.M.: Neurobiology and programming capacity of attachment learning to nurturing and abusive caregivers. Environmental Experience and Plasticity of the Developing Brain. Alessandro Sale (eds.). Wiley, In press, 2014.

Barr G A, Wang S: Analgesia induced by localized injection of opiate peptides into the brain of infant rats. European journal of Pain 17(5): 676-91, 2013.

Marion, M., Santi, L., Monaghan R., Houle J.D., Barr G. A.: Peripheral nerve graft with immunosuppression modifies gene expression in axotomized CNS neurons. The Journal of Comparative Neurology 519(17): 3433-55, 2011.

Chan, T., Kyere, K., Davis, B.R., Shemyakin, A., Kabitzke, P.A., Shair, H.N., Barr, G.A., Wiedenmayer, C.P.: The role of the medial prefrontal cortex in innate fear regulation in infants, juveniles, and adolescents. Journal of Neuroscience 31(13): 4991-4999, 2011.

Barr Gordon A: Formalin-induced c-fos expression in the brain of infant rats. The Journal of Pain 12(2): 263-71, 2011.

Barr G. A., Moriceau S., Shionoya K., Muzny K., Gao P., Wang S., Sullivan R. M.: Transitions in infant learning are modulated by dopamine in the amygdala. Nature Neuroscience 12(11): 1367-9, 2009.

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Last updated: 12/02/2014
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