J. Eduardo Rame

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Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Attending, Cardiac Catherization Laboratory, Hospital of the University of Pennsylvania
Attending, Heart Failure, Mechanical Assist, and Cardiac Transplantation Program, Hospital of the University of Pennsylvania
Attending, Pulmonary Hypertension Program, Hospital of the University of Pennsylvania
Medical Director, Mechanical Circulatory Support Program, Hospital of the University of Pennsylvania
Interim Director, Pulmonary Hypertension Program - Hospital of the University of Pennsylvania
Department: Medicine

Contact information
Penn Medicine
Heart Failure, Mechanical Assist and Cardiac Transplant Center
Hospital of the University of Pennsylvania
2 East, Perelman Center for Advanced Medicine
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 215-615-7949
Fax: 215-349-5603
Education:
B.S., M.S. (Molecular Biophysics and Biochemistry)
Yale College, 1990.
M.Phil (Statistics/Health Services Research)
Oxford University , 1996.
M.D. (Medicine)
Harvard Medical School , 1997.
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Description of Itmat Expertise

Metabolic Signature of Chronic Heart Failure

Cardiac Metabolism

Ventricular Assist Device Support

Right Ventricular Dysfunction in Chronic Mechanically Assisted Heart Failure

Description of Research Expertise

My role as an advanced heart failure clinician-scientist and director of the mechanical assist device program at Penn is to provide expertise in the area of myocardial failure in the more advanced stage of this syndrome. More recently I have been working on the emerging interface of metabolism and heart failure. The current focus of my research is the investigation of myocardial and systemic metabolism in the syndrome of chronic heart failure. Specifically, myocardial and systemic insulin resistance is being increasingly targeted as a mechanism of disease progression in chronic heart failure and the objectives as a translational researcher within my group have been to: 1. Understand the role of lipid and adipocytokine biology (leptin, adiponectin, resistin) in the emerging metabolic phenotype of heart failure; 2. Identify specific targets for improving myocardial energetics and whole-body metabolism in cardiomyopathic failure; and 3. Test the safety and efficacy through carefully designed pilot studies of “reversing” specific metabolic pathways which have been dysregulated in human heart failure. My collaborative network for this research currently includes the laboratories of Dr. Tim McGraw, Dr. Richard Shannon, Dr. Ken Margulies and Dr. Tom Cappola within my own group at Penn as well as the laboratory of Dr. Christian Schulze and Professor Ira Goldberg at Columbia University.

Selected Publications

Rame JE, Vaidya A: Disease Progression in Pulmonary Arterial Hypertension: Refining the Phenotype With a Prognostic Biomarker Profile From Collagen. JACC Heart Fail. In press: S2213-1779, July 2014.

Birati EY, Rame JE: Post–Heart Transplant Complications Critical Care Clinics Elsevier, 30(3): 629–637, July 2014.

Rame JE, Vaidya A : Disease Progression in Pulmonary Arterial Hypertension: Refining the Phenotype With a Prognostic Biomarker Profile From Collagen. JACC Heart Fail July 2014 Notes: Epub ahead of print.

Patel1 AM, Rame JE, Rudnick MR: How Does the Nephrologist Manage an LVAD Patient on Chronic Maintenance Dialysis? Seminars in Dialysis 27(3): 284–288, May–June 2014 Notes: Article first published online: 21 MAR 2014

Rame JE, Atluri P, Acker MA: Unexpected Abrupt Increase in Left Ventricular Assist Device Thrombosis N Engl J Med 370: 1466-1467, April 2014.

Santangeli P, Muser D, Zado E, Hutchinson M, Supple G, Frankel D, Garcia F, Bala R, Riley M, Rame JE, Dixit S, Marchlinski F, Callans D: Acute Hemodynamic Decompensation During Catheter Ablation of Scar-Related VT: Incidence, Predictors and Impact on Mortality. Heart Rhythm Submitted, December 2013.

Ramjee V, Shreenivas S, Rame JE, Kirkpatrick JN, Jagasia D: Complete Spontaneous Left Heart and Aortic Thromboses on Extracorporeal Membrane Oxygenation Support. Echocardiography (Mount Kisco, N.Y.). (eds.). 30(10): E342–E343, Nov 2013 Notes: Epub 2013 Jul 27.

Starling RC, Moazami N, Silvestry SC, Ewald G, Rogers JG, Milano CA, Rame JE, Acker MA, Blackstone EH, Ehrlinger J, Thuita L, Mountis MM, Soltesz EG, Lytle BW, Smedira NG: Unexpected Abrupt Increase in Left Ventricular Assist Device Thrombosis. The New England Journal of Medicine 370(1): 1-8, Nov 2013.

Rame JE: Is Chronic Heart Failure a Reversible Metabolic Syndrome. Heart And Metabolism. Mario Marzilli (eds.). Servier, 61, November 2013.

Neeland IJ, Gupta S, Ayers CR, Turer AT, Rame JE, Das SR, Berry JD, Khera A, McGuire DK, Vega GL, Grundy SM, de Lemos JA, Drazner MH: Relation of regional fat distribution to left ventricular structure and function. Circ Cardiovasc Imaging 6(5): 800-7, Sep 2013.

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Last updated: 07/24/2014
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