Kyoung Jae Won

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Research Assistant Professor of Genetics
Department: Genetics

Contact information
Institute for Diabetes, Obesity and Metabolism
Perelman School of Medicine
12-111 Smilow Center for Translational Research
3400 Civic Center Blvd.
Philadelphia, PA 19104
Lab: 215-746-8424
Education:
B.Sc. (Electronics)
Chung-Ang University, Korea, 1996.
M.Sc. (Electronics )
Chung-Ang University, Korea, 1999.
Ph.D. (Electronics and Computer Science)
University of Southampton, UK, 2005.
Permanent link
 

Description of Itmat Expertise

computational epigenomics
bioinformatics
transcriptional network

Selected Publications

Harms Matthew J, Lim Hee-Woong, Ho Yugong, Shapira Suzanne N, Ishibashi Jeff, Rajakumari Sona, Steger David J, Lazar Mitchell A, Won Kyoung-Jae, Seale Patrick: PRDM16 binds MED1 and controls chromatin architecture to determine a brown fat transcriptional program. Genes & development 29(3): 298-307, Feb 2015.

Choi Inchan, Kim Rinho, Lim Hee-Woong, Kaestner Klaus H, Won Kyoung-Jae: 5-hydroxymethylcytosine represses the activity of enhancers in embryonic stem cells: a new epigenetic signature for gene regulation. BMC genomics 15: 670, 2014.

Nguyen Nha, Vo An, Won Kyoung-Jae: A wavelet-based method to exploit epigenomic language in the regulatory region. Bioinformatics (Oxford, England) 30(7): 908-14, Apr 2014.

Step Sonia E, Lim Hee-Woong, Marinis Jill M, Prokesch Andreas, Steger David J, You Seo-Hee, Won Kyoung-Jae, Lazar Mitchell A: Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARĪ³-driven enhancers. Genes & development 28(9): 1018-28, May 2014.

Lake Robert J, Tsai Pei-Fang, Choi Inchan, Won Kyoung-Jae, Fan Hua-Ying: RBPJ, the Major Transcriptional Effector of Notch Signaling, Remains Associated with Chromatin throughout Mitosis, Suggesting a Role in Mitotic Bookmarking. PLoS genetics 10(3): e1004204, Mar 2014.

Won Kyoung-Jae, Zhang Xian, Wang Tao, Ding Bo, Raha Debasish, Snyder Michael, Ren Bing, Wang Wei: Comparative annotation of functional regions in the human genome using epigenomic data. Nucleic acids research 41(8): 4423-32, Apr 2013.

Won Kyoung-Jae, Ren Bing, Wang Wei: Genome-wide prediction of transcription factor binding sites using an integrated model. Genome biology 11(1): R7, 2010.

Xie Ruiyu, Everett Logan J, Lim Hee-Woong, Patel Nisha A, Schug Jonathan, Kroon Evert, Kelly Olivia G, Wang Allen, D'Amour Kevin A, Robins Allan J, Won Kyoung-Jae, Kaestner Klaus H, Sander Maike: Dynamic chromatin remodeling mediated by polycomb proteins orchestrates pancreatic differentiation of human embryonic stem cells. Cell stem cell 12(2): 224-37, Feb 2013.

Won Kyoung-Jae, Xu Zheng, Zhang Xian, Whitaker John W, Shoemaker Robert, Ren Bing, Xu Yang, Wang Wei: Global identification of transcriptional regulators of pluripotency and differentiation in embryonic stem cells. Nucleic acids research 40(17): 8199-209, Sep 2012.

Won Kyoung-Jae, Chepelev Iouri, Ren Bing, Wang Wei: Prediction of regulatory elements in mammalian genomes using chromatin signatures. BMC bioinformatics 9: 547, 2008.

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Last updated: 03/24/2015
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