Masahiro Iwamoto

faculty photo
Research Associate Professor of Orthopaedic Surgery
Scientist II, The Children's Hospital of Philadelphia Research Institute
Department: Orthopaedic Surgery

Contact information
The Children's Hospital of Philadelphia
Translational Research Program in Pediatric Orthopaedics
Division of Orthopaedic Surgery
Department of Surgery
3615 Civic Center Boulevard
Abramson Research Center 910A
Philadelphia, PA 19104
Office: 267-425-2072
Fax: 267-426-2215
D.D.S (Dental School)
Tokushima, 1984.
Ph.D (Dentistry)
Osaka University, 1988.
Permanent link

Description of Itmat Expertise

Prevention and treatment for heterotopic ossification.
Connective tissue repair
Development, maintanance, and repair of articular cartilage
Regulation of cell differentiation by nuclear retinoid receptors

Description of Research Expertise

Developmental biology of bone and cartilage.
Tissue degeneration of skeletal tissue and muscle.
Microsurgery of small animals.

Selected Publications

Maria Elena Candela, Leslie Cantley, Rika Yasuaha, Masahiro Iwamoto, Maurizio Pacifici, and Motomi Enomoto-Iwamoto: Distribution of Slow-Cycling Cells in Epiphyseal Cartilage and Requirement of β-Catenin Signaling for Their Maintenance in Growth Plate. J. Orthop. Res. 2014 Notes: in press.

Iwamoto M, Ohta Y, Larmour C and Enomoto-Iwamoto M.: Towards Regeneration of Articular Cartilage. Birth Defects Res (Part C) 99(3): 192-202, Sep 2013.

Horikiri Y, Shimo T, Kurio N, Okui T, Matsumoto K, Iwamoto M, Sasaki A.: Sonic hedgehog regulates osteoblast function by focal adhesion kinase signaling in the process of fracture healing. PlosOne 8(10): e76785, 10 2013.

Leslie Cantley, Cheri Saunders, Marta Guttenberg, Maria Elena Candela, Yoichi Ohta, Rika Yasuhara, Naoki Kondo, Federica Sgariglia, Shuji Asai, Julianne Hugel, Xianrong Zhang, Ling Qin, Jacqueline T. Hecht, Di Chen, Masato Yamamoto, Satoru Toyosawa, John Paul Dormans, Jeffrey D. Esko, Yu Yamaguchi, Masahiro Iwamoto, Maurizio Pacifici, Motomi Enomoto-Iwamoto: Loss of β-Catenin Induces Multifocal Periosteal Chondroma-like Masses in Mice. American Journal of Pathology 2013 Notes: Manuscript#AJP12-0453 Version 2: accepted for publication.

Shimono K, Uchibe K, Kuboki T, Iwamoto M. : The pathophysiology of heterotopic ossification: Current treatment considerations in dentistry. Jap Dental Science Review 2013 Notes: E-pub doi:10.1016/j.jdsr.2013.07.003.

Otsuru S, Gordon PL, Shimono K, Jethva R, Marino R, Phillips CL, Hofmann TJ, Veronesi E, Dominici M, Iwamoto M, Horwitz EM.: Transplanted bone marrow mononuclear cells and MSCs impart clinical benefit to children with osteogenesis imperfecta through different mechanisms. Blood 120(9): 1933-41, Aug 2012.

Honami T, Shimo T, Okui T, Kurio N, Hassan NM, Iwamoto M, Sasaki A.: Sonic hedgehog signaling promotes growth of oral squamous cell carcinoma cells associated with bone destruction. Oral Oncol. 48(1): 49-55, Jan 2012.

M. Enomoto-Iwamoto, C. Sunders, Y. Ohta, M. Guttenberg, R. Yasuhara, K. Shimono, N. Kondo, S. Asai, J. Hecht, S. Mackem, D. Chen, J. P. Dormans, M. Iwamoto, M. Pacifici : Loss of β-Catenin Induces Multifocal Ectopic Chondroma-like Masses in Adult Mice. Transactions/ Orthopaedic Research Society 37: 0265, 2012 Notes: 58th Annual Meeting of the Orthopaedic Research Society.

Y. Ohta, T. Okabe, S. Asai, A. Di Rocco, C. Larmour, M. Enomoto-Iwamoto, M. Pacifici, M. Iwamoto: Transcription Factor Erg Is Required for Long-term Articular Cartilage Maintenance. Transactions/ Orthopaedic Research Society 37: 341, 2012 Notes: 58th Annual Meeting of the Orthopaedic Research Society.

S. Asai, K. Shimono, W. Tung, M. Pacifici, M. Iwamoto, M. Enomoto-Iwamoto: Progenitors Recruited to Injured Tendons Are Possible Culprits of Chondroid Degeneration. Transactions/ Orthopaedic Research Society 37: 141, 2012 Notes: 58th Annual Meeting of the Orthopaedic Research Society.

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Last updated: 01/19/2014
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