Masahiro Iwamoto

faculty photo
Research Associate Professor of Orthopaedic Surgery
Scientist II, The Children's Hospital of Philadelphia Research Institute
Department: Orthopaedic Surgery

Contact information
The Children's Hospital of Philadelphia
Translational Research Program in Pediatric Orthopaedics
Division of Orthopaedic Surgery
Department of Surgery
3615 Civic Center Boulevard
Abramson Research Center 910A
Philadelphia, PA 19104
Office: 267-425-2072
Fax: 267-426-2215
D.D.S (Dental School)
Tokushima, 1984.
Ph.D (Dentistry)
Osaka University, 1988.
Permanent link

Description of Itmat Expertise

Prevention and treatment for heterotopic ossification.
Connective tissue repair
Development, maintanance, and repair of articular cartilage
Regulation of cell differentiation by nuclear retinoid receptors

Description of Research Expertise

Developmental biology of bone and cartilage.
Tissue degeneration of skeletal tissue and muscle.
Microsurgery of small animals.

Selected Publications

Gabriel J. Pavey, Ammar T. Qureshi, Allison M. Tomasino, Cary L. Honnold, Danett K. Bishop, Shailesh Agarwal, Shawn Loder, Benjamin Levi, Maurizio Pacifici, Masahiro Iwamoto, Benjamin K. Potter, Thomas A. Davis, Jonathan A. Forsberg: Targeted Stimulation of Retinoic Acid Receptor-γ Mitigates the Formation of Heterotopic Ossification in an Established Blast-Related Traumatic Injury Model. Bone 90: 159-167, June 2016 Notes: doi: 10.1016/j.bone.2016.06.014.

Zhang, K., Asai, S., Hast, M. W., Liu, M., Usami, Y., Iwamoto, M., Soslowsky, L. J., Enomoto-Iwamoto, M.: Tendon mineralization is progressive and associated with deterioration of tendon biomechanical properties, and requires BMP-Smad signaling in the mouse Achilles tendon injury model. Matrix Biol 52-54: 315-324, May-July 2016 Notes: 10.1016/j.matbio.2016.01.015.

Sinha, S., Uchibe, K., Usami, Y., Pacifici, M., Iwamoto, M.: Effectiveness and mode of action of a combination therapy for heterotopic ossification with a retinoid agonist and an anti-inflammatory agent. Bone Feb 2016 Notes: doi: 10.1016/j.bone.2016.02.008.

Chakkalakal, S. A., Uchibe, K., Convente, M. R., Zhang, D., Economides, A. N., Kaplan, F. S., Pacifici, M., Iwamoto, M., Shore, E. M.: Palovarotene Inhibits Heterotopic Ossification and Maintains Limb Mobility and Growth in Mice With the Human ACVR1 Fibrodysplasia Ossificans Progressiva (FOP) Mutation. J Bone Miner Res 2016 Notes: 10.1002/jbmr.2820.

Kenta Uchibe, Jiyeon Son, Colleen Larmour, Maurizio Pacifici, Motomi-Enomoto-Iwamoto, Masahiro Iwamoto: Genetic and pharmacological inhibition of retinoic acid receptor γ function promotes endochondral bone formation. Journal of Orthopaedic Research 2016 Notes: Accepted for publication on 6/14/2016. Manuscript number JOR-16-0151.R1.

Usami, Y., Gunawardena, A. T., Iwamoto, M., Enomoto-Iwamoto, M.: Wnt signaling in cartilage development and diseases: lessons from animal studies. Lab invest 96(2): 186-96, 2016.

Usami Y, Gunawardena AT, Iwamoto M, Enomoto-Iwamoto M.: Wnt signaling in cartilage development and diseases: lessons from animal studies. Lab Invest. Page: doi: 10.1038/labinvest.2015.142 (ePub ahead of print), Dec 2015.

Usami Yu, Gunawardena Aruni T, Iwamoto Masahiro, Enomoto-Iwamoto Motomi: Wnt signaling in cartilage development and diseases: lessons from animal studies. Laboratory investigation; a journal of technical methods and pathology Dec 2015.

Ohta Yoichi, Okabe Takahiro, Larmour Colleen, Di Rocco Agnese, Maijenburg Marijke W, Phillips Amanda, Speck Nancy A, Wakitani Shigeyuki, Nakamura Takashi, Yamada Yoshihiko, Enomoto-Iwamoto Motomi, Pacifici Maurizio, Iwamoto Masahiro: Articular cartilage endurance and resistance to osteoarthritic changes require transcription factor Erg. Arthritis & rheumatology (Hoboken, N.J.) 67(10): 2679-90, Oct 2015.

Di Rocco Agnese, Uchibe Kenta, Larmour Colleen, Berger Rebecca, Liu Min, Barton Elisabeth R, Iwamoto Masahiro: Selective Retinoic Acid Receptor γ Agonists Promote Repair of Injured Skeletal Muscle in Mouse. The American journal of pathology 185(9): 2495-504, Sep 2015.

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Last updated: 09/07/2016
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