Steven Brem

faculty photo
Professor of Neurosurgery at the Hospital of the University of Pennsylvania
Department: Neurosurgery

Contact information
3400 Spruce Street, 3rd Floor Silverstein
Department of Neurosurgery
Philadelphia, PA 19104
Office: (215) 662-7854
Education:
BA (Magna Cum Laude)
Rutgers University, 1968.
MD (Medicine - Cum Laude)
Harvard Medical School, 1972.
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Description of Itmat Expertise

Experimental therapeutics, brain tumors, angiogenesis, tumor invasion, genomics, clinical trials, radiosurgery, brain mapping, connectomics,

Description of Research Expertise

Angiogenesis, Neuro-Oncology, Translational Drug Discovery, Personalized Medicine, Genomics, Biomarkers, Experimental Therapeutics, Brain Mapping, Health Outcomes, Brain Metastases, Clinical Guidelines, Clinical Pathways, Glioma Invasion, Targeted Brain Tumor Therapies

Selected Publications

Brem Steven, Meyers Christina A, Palmer Gary, Booth-Jones Margaret, Jain Surbhi, Ewend Matthew G: Preservation of neurocognitive function and local control of 1 to 3 brain metastases treated with surgery and carmustine wafers. Cancer 119(21): 3830-8, Nov 2013.

Chacko Ann-Marie, Li Chunsheng, Pryma Daniel A, Brem Steven, Coukos George, Muzykantov Vladimir: Targeted delivery of antibody-based therapeutic and imaging agents to CNS tumors: crossing the blood-brain barrier divide. Expert opinion on drug delivery 10(7): 907-26, Jul 2013.

Abdullah Kalil G, Lubelski Daniel, Nucifora Paolo G P, Brem Steven: Use of diffusion tensor imaging in glioma resection. Neurosurgical focus 34(4): E1, Apr 2013.

Nabors L Burt, Mikkelsen Thomas, Hegi Monika E, Ye Xiaubu, Batchelor Tracy, Lesser Glenn, Peereboom David, Rosenfeld Myrna R, Olsen Jeff, Brem Steve, Fisher Joy D, Grossman Stuart A: A safety run-in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306). Cancer 118(22): 5601-7, Nov 2012.

Xiao Yuanyuan, Decker Paul A, Rice Terri, McCoy Lucie S, Smirnov Ivan, Patoka Joseph S, Hansen Helen M, Wiemels Joe L, Tihan Tarik, Prados Michael D, Chang Susan M, Berger Mitchel S, Kosel Matthew L, Fridley Brooke L, Lachance Daniel H, O'Neill Brian Patrick, Buckner Jan C, Thompson Reid C, Nabors Louis Burt, Olson Jeffrey J, Brem Steve, Madden Melissa H, Browning James E, Wiencke John K, Egan Kathleen M, Jenkins Robert B, Wrensch Margaret R: SSBP2 variants are associated with survival in glioblastoma patients. Clinical cancer research : an official journal of the American Association for Cancer Research 18(11): 3154-62, Jun 2012.

Seaman Brian, Brem Steven, Fromm Allison, Staller Aileen, McCardle Timothy, Jain Surbhi: Intracranial spread of Merkel cell carcinoma to the cerebellopontine angle. Journal of cutaneous medicine and surgery 16(1): 54-60, Jan-Feb 2012.

Chinnaiyan Prakash, Chowdhary Sajeel, Potthast Lisa, Prabhu Antony, Tsai Ya-Yu, Sarcar Bhaswati, Kahali Soumen, Brem Steven, Yu H Michael, Rojiani Amyn, Murtagh Ryan, Pan Edward: Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma. Neuro-oncology 14(1): 93-100, Jan 2012.

Moody Patricia, Murtagh Kevin, Piduru Sarat, Brem Steven, Murtagh Reed, Rojiani Amyn M: Tumor-to-tumor metastasis: pathology and neuroimaging considerations. International journal of clinical and experimental pathology 5(4): 367-73, 2012.

Egan KM, Thompson RC, Nabors LB, Olson JJ, Brat DJ, LaRocca RV, Brem S, Moots PL, Madden MH, Browning JE, Chen AY: Cancer susceptibility variants and the risk of adult glioma in a US case-control study. J Neurooncol Jan 2011 Notes: Epub ahead of print.

Brem S, Jain S, commentary to: Yang X, Cao W, Zhou J, Zhang W, Zhang X, Lin W, Fei Z, Lin H, Wang B: 14-3-zeta positive expression is associated with a poor prognosis in patients with glioblastoma. Neurosurgery 68: 938, 2011.

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Last updated: 01/28/2013
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