Alejandro Carabe-Fernandez

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Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Search Committee - Assistant Professor Tenure-Track, University of Pennsylvania Dept. of Radiation Oncology
Department: Radiation Oncology

Contact information
Hospital of the University of Pennsylvania
Department of Radiation Oncology
TRC 4 West, 4-324W
3400 Civic Center Boulevard
Phiadelphia, PA 19104
Office: (215) 614-1605
Education:
MPhys (Physics with Medical Technology)
University of Hull, 2000.
MSc (Medical Physics)
University of Glasgow, 2002.
Ph.D. (Radiobiology)
Imperial College, 2008.
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Description of Itmat Expertise

1) Radiotherapy treatment optimization based on radiobiological considerations in pediatric brain, or head and neck. I am specifically interested in craniopharyngioma.

2) development of proton arc therapy techniques that would allow to treat with higher doses to the tumor while keeping dose constrains to the normal tissue

3) Development of Tumor control probability/normal tissue complication probability models for radiotherapy radiobiological optimization

4) neutron boost in proton radiotherapy treatments to overcome radioresistance due to hypoxia

5) cyclotron based neutron beams by adding a berilium target to a proton line

Description of Research Expertise

Clinical and theoretical radiobiology
High-LET radiobiology and radiotherapy
Radiobiological Optimization
TCP/NTCP specific for high-LET radiations
Repair kinetics modeling

Selected Publications

Mayer R, Lin L, Fager M, Douglas D, McDonough J, Carabe A.: Proposed linear energy transfer areal detector for protons using radiochromic film. Rev Sci Instrum. 86((4)): 044301, Apr 2015.

Cortés-Giraldo MA, Carabe A.: A critical study of different Monte Carlo scoring methods of dose average linear-energy-transfer maps calculated in voxelized geometries irradiated with clinical proton beams. Phys Med Biol. 60(7), Apr 2015.

Fager M, Toma-Dasu I, Kirk M, Dolney D, Diffenderfer ES, Vapiwala N, Carabe A.: Linear energy transfer painting with proton therapy: a means of reducing radiation doses with equivalent clinical effectiveness. Int J Radiat Oncol Biol Phys. 91(5): 1057-64, Apr 2015.

Darafsheh A, Guardiola C, Palovcak A, Finlay JC, Cárabe A: Optical super-resolution imaging by high-index microspheres embedded in elastomers. Opt Lett 40(1): 5-8, Jan 2015.

C. Guardiola, A. Carabe, F. Gómez, G. Pellegrini, C. Fleta, S. Esteban, D. Quirion, M. Lozano : First Silicon Microdosimeters Based on Cylindrical Diodes Sensors & Transducers 183(12): 129-133, Dec 2014.

Sánchez-Parcerisa D, Kondrla M, Shaindlin A, Carabe A.: FoCa: a modular treatment planning system for proton radiotherapy with research and educational purposes. Phys Med Biol. 59(23): 7341-60, Dec 2014.

C. Guardiola, A. Carabe, F. Gómez, G. Pellegrini, C. Fleta, S. Esteban, D. Quirion, M. Lozano: First Silicon Microdosimeters Based on Cylindrical Diodes. Sensors & Transducers 183(12): 129-133, Dec 2014.

Lin L, Solberg TD, Carabe A, Mcdonough JE, Diffenderfer E, Sanzari JK, Kennedy AR, Cengel K.: Pencil beam scanning dosimetry for large animal irradiation. J Radiat Res 55(5): 855-61, Sep 2014.

Sánchez-Parcerisa D, Pourbaix JC, Ainsley CG, Dolney D, Carabe A: Fast range switching of passively scattered proton beams using a modulation wheel and dynamic beam current modulation. Phys Med Biol 59(7): N19-26, Apr 2014.

Carabe A, España S, Grassberger C, Paganetti H: Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver. Phys Med Biol 58(7): 2103-17, 2013.

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Last updated: 05/13/2015
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