Alejandro Carabe-Fernandez

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Assistant Professor of Radiation Oncology at the Hospital of the University of Pennsylvania
Search Committee - Assistant Professor Tenure-Track, University of Pennsylvania Dept. of Radiation Oncology
Department: Radiation Oncology

Contact information
Hospital of the University of Pennsylvania
Department of Radiation Oncology
TRC 4 West, 4-324W
3400 Civic Center Boulevard
Phiadelphia, PA 19104
Office: (215) 614-1605
MPhys (Physics with Medical Technology)
University of Hull, 2000.
MSc (Medical Physics)
University of Glasgow, 2002.
Ph.D. (Radiobiology)
Imperial College, 2008.
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Description of Itmat Expertise

1) Radiotherapy treatment optimization based on radiobiological considerations in pediatric brain, or head and neck. I am specifically interested in craniopharyngioma.

2) development of proton arc therapy techniques that would allow to treat with higher doses to the tumor while keeping dose constrains to the normal tissue

3) Development of Tumor control probability/normal tissue complication probability models for radiotherapy radiobiological optimization

4) neutron boost in proton radiotherapy treatments to overcome radioresistance due to hypoxia

5) cyclotron based neutron beams by adding a berilium target to a proton line

Description of Research Expertise

Clinical and theoretical radiobiology
High-LET radiobiology and radiotherapy
Radiobiological Optimization
TCP/NTCP specific for high-LET radiations
Repair kinetics modeling

Selected Publications

Carabe A, EspaƱa S, Grassberger C, Paganetti H: Clinical consequences of relative biological effectiveness variations in proton radiotherapy of the prostate, brain and liver. Phys Med Biol 58(7): 2103-17, 2013.

Alejandro Carabe-Fernandez: Radiobiology for Proton and Carbon Ion Therapy. Proton and Carbon Ion Therapy. Charlie Ma and Tony Lomax (eds.). CRC Press, Page: 71, October 2012.

Carabe A, Moteabbed M, Depauw N, Schuemann J, Paganetti H.: Range uncertainty in proton therapy due to variable biological effectiveness. Phys Med Biol. IoP, 57(5): 1159-72, March 2012.

Butterworth KT, McGarry CK, Clasie B, Carabe-Fernandez A, Schuemann J, Depauw N, Tang S, McMahon SJ, Schettino G, O'Sullivan JM, Lu HM, Kooy H, Paganetti H, Hounsell AR, Held KD, Prise KM.: Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries. Phys Med Biol 57(20): 6671-80, 2012.

Carabe-Fernandez A, Dale RG, Jones B: Repair kinetic considerations in high-LET particle beam radiotherapy. Br J Radiol 2011 Notes: in press.

Jones B, Underwood TS, Carabe-Fernandez A, Timlin C, Dale RG.: Fast neutron relative biological effects and implications for charged particle therapy. British Journal of Radiology 84(1): S11-S18, 2011.

Carabe-Fernandez A, Dale RG, Hopewell JW, Jones B, Paganetti H: Fractionation effects in particle radiotherapy: implications for hypo-ractionation regimes. Phys Med Biol 55(19): 5685-700, 2010.

Jones B, Dale RG, Carabe-Fernandez A: Charged particle therapy for cancer: The inheritance of the Cavendish scientists? Appl Radiat Isot 67(3): 371-7, 2009.

Dale RG, Jones B, Carabe-Fernandez A: Why more needs to be known about RBE effect in modern radiotherapy. Appl Radiat Isot 67(3): 387-92, 2009.

Jones B, Carabe-Fernandez A, Dale RG: The oxygen effect. Radiobiological Modeling in Radiation Oncology. Dale RG and Jones B (eds.). The British Institute of Radiology, Page: 138-157, 2007.

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Last updated: 02/24/2014
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