Aalim M. Weljie

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Research Assistant Professor of Pharmacology
Department: Pharmacology

Contact information
10-113 Translational Research Center
3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104
Office: 215-573-8085
Lab: 215-898-2220
B.Sc. (Chemistry; Certificate in Engineering)
Mount Allison University, 1996.
Ph.D. (Biochemistry)
University of Calgary, 2002.
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Description of Itmat Expertise

Metabolomics, NMR spectroscopy, Mass spectrometry, multivariate statistical analysis

Description of Research Expertise

The Weljie Lab is located in the Department of Pharmacology at the University of Pennsylvania. Our lab is at the forefront of metabolomics technologies to examine biological problems in a translational medicine context.

Metabolomics is a growing sub-field of systems biology centered on the study of small biological molecules in biological fluids and tissues. Recent research suggests that analysis of metabolite concentrations in living systems is useful in disease diagnosis, prognosis, and predicting drug efficacy in a personalized medicine context.

Our focus is on developing analytical methods to advance research in translational medicine. There is an intrinsic link between metabolism and function of the innate circadian clock system in numerous organisms and disease states, but the exact mechanism by which the clock controls mammalian metabolism is poorly understood. Our work seeks to fill this knowledge gap along with identifying biomarkers of cancer and environmental health.

Selected Publications

Ngoc-Ha T. Dang, Bo Young Ahn, Laszlo G. Boros, Donna Senger, Aalim M. Weljie: Targeting the distinct roles of acetyl-CoA carboxylase and fatty acid synthase in the fatty acid synthesis pathway of glioblastoma multiformes metabolism. Cold Spring Harbor Symposium: Metabolic Signaling & Disease: from Cell to Organism August 2013.

Athersuch Toby J, Malik Shahid, Weljie Aalim, Newton Jack, Keun Hector C: Evaluation of (1)H NMR Metabolic Profiling Using Biofluid Mixture Design. Analytical chemistry 85(14): 6674-81, Jun 2013.

Reimer RA, Maurer AD, Eller LK, Hallam MC, Shaykhutdinov R, Vogel HJ, Weljie AM: Satiety hormone and metabolomic response to an intermittent high energy diet differs in rats consuming long-term diets high in protein or prebiotic fibre. J. Proteome Res. 11(8): 4065-74, August 2012.

Dang, N. Ha, Kalkat, Manpreet, Luchman, Artee2, Oyelusi, Wale2, Senger, Donna, Weljie, Aalim M: Metabolomics approach for characterizing fatty acid synthesis pathway – a target for brain tumour therapies. 8th International Conference of the Metabolomics Society, Washington, DC June 2012 Notes: Oral.

Farshad Farshidfar, Aalim M. Weljie, Karen Kopciuk, Hans J. Vogel, Oliver F. Bathe: Metabolomic Profile of Colorectal Cancer Patients Shows Reproducibility in Pre- Operative and Intra-Operative Conditions. 8th International Meeting of the Metabolomics Society, Washington, DC June 2012 Notes: Oral.

Jeffery Herman: "Metabolomics Continues Auspicious Climb" Genetic Engineering and Biotechnology News 32(9), May 2012 Notes: Interview.

Farshidfar Farshad, Weljie Aalim M, Kopciuk Karen, Buie W Don, Maclean Anthony, Dixon Elijah, Sutherland Francis R, Molckovsky Andrea, Vogel Hans J, Bathe Oliver F: Serum metabolomic profile as a means to distinguish stage of colorectal cancer. Genome medicine 4(5): 42, May 2012.

Luchman H Artee, Stechishin Owen D, Dang N Ha, Blough Michael D, Chesnelong Charles, Kelly John J, Nguyen Stephanie A, Chan Jennifer A, Weljie Aalim M, Cairncross J Gregory, Weiss Samuel: An in vivo patient-derived model of endogenous IDH1-mutant glioma. Neuro-oncology 14(2): 184-91, Feb 2012.

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Last updated: 08/29/2014
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