Aalim M. Weljie

faculty photo
Research Assistant Professor of Pharmacology
Member, Center of Excellence in Environmental Toxicology
Member, Institute of Translational Medicine and Therapeutics
Department: Pharmacology

Contact information
10-113 Smilow Center for Translational Research
3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104
Office: 215-573-8085
Lab: 215-898-2220
Education:
B.Sc. (Chemistry; Certificate in Engineering)
Mount Allison University, 1996.
Ph.D. (Biochemistry)
University of Calgary, 2002.
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Description of Itmat Expertise

Metabolomics, NMR spectroscopy, Mass spectrometry, multivariate statistical analysis

Description of Research Expertise

The Weljie Lab is located in the Department of Systems Pharmacology and Translational Therapeutics within the Perelman School of Medicine at the University of Pennsylvania. Our lab is at the forefront of metabolomics technologies to examine biological problems in a translational medicine context, particularly related to sleep and circadian rhythms.

Metabolomics is a growing sub-field of systems biology centered on the study of small biological molecules in biological fluids and tissues. Recent research suggests that analysis of metabolite concentrations in living systems is useful in disease diagnosis, prognosis, and predicting drug efficacy in a personalized medicine context.

There is an intrinsic link between metabolism and function of the innate circadian clock system in numerous organisms and disease states, but the exact mechanism by which the clock controls mammalian metabolism is poorly understood. Our work seeks to fill this knowledge gap along with a particular emphasis on understanding the relationship of the clock with cancer and environmental health.

Selected Publications

Rhoades SD, Sengupta A, Weljie AM: Time is ripe: maturation of metabolomics in chronobiology. Current Opinion in Biotechnology 43: 70-76, 2017.

Sarfaraz M Omair, Myers Robert P, Coffin Carla S, Gao Zu-Hua, Shaheen Abdel Aziz M, Crotty Pam M, Zhang Ping, Vogel Hans J, Weljie Aalim M: A quantitative metabolomics profiling approach for the noninvasive assessment of liver histology in patients with chronic hepatitis C. Clinical and translational medicine 5(1): 33, Dec 2016.

Farshidfar Farshad, Weljie Aalim M, Kopciuk Karen A, Hilsden Robert, McGregor S Elizabeth, Buie W Donald, MacLean Anthony, Vogel Hans J, Bathe Oliver F: A validated metabolomic signature for colorectal cancer: exploration of the clinical value of metabolomics. British journal of cancer 115(7): 848-857, Sep 2016.

Jang Cholsoon, Oh Sungwhan F, Wada Shogo, Rowe Glenn C, Liu Laura, Chan Mun Chun, Rhee James, Hoshino Atsushi, Kim Boa, Ibrahim Ayon, Baca Luisa G, Kim Esl, Ghosh Chandra C, Parikh Samir M, Jiang Aihua, Chu Qingwei, Forman Daniel E, Lecker Stewart H, Krishnaiah Saikumari, Rabinowitz Joshua D, Weljie Aalim M, Baur Joseph A, Kasper Dennis L, Arany Zoltan: A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nature medicine 22(4): 421-6, Apr 2016.

Beaudry Paul, Campbell Martin, Dang N Ha, Wen Jing, Blote Karen, Weljie Aalim M: A Pilot Study on the Utility of Serum Metabolomics in Neuroblastoma Patients and Xenograft Models. Pediatric blood & cancer 63(2): 214-20, Feb 2016.

Sengupta Arjun, Krishnaiah Saikumari Y, Rhoades Seth, Growe Jacqueline, Slaff Barry, Venkataraman Anand, Olarerin-George Anthony O, Van Dang Chi, Hogenesch John B, Weljie Aalim M: Deciphering the Duality of Clock and Growth Metabolism in a Cell Autonomous System Using NMR Profiling of the Secretome. Metabolites 6(3), 2016.

Hao Desirée, Sarfaraz M Omair, Farshidfar Farshad, Bebb D Gwyn, Lee Camelia Y, Card Cynthia M, David Marilyn, Weljie Aalim M: Temporal characterization of serum metabolite signatures in lung cancer patients undergoing treatment. Metabolomics : Official journal of the Metabolomic Society 12: 58, 2016.

Altman Brian J, Hsieh Annie L, Sengupta Arjun, Krishnanaiah Saikumari Y, Stine Zachary E, Walton Zandra E, Gouw Arvin M, Venkataraman Anand, Li Bo, Goraksha-Hicks Pankuri, Diskin Sharon J, Bellovin David I, Simon M Celeste, Rathmell Jeffrey C, Lazar Mitchell A, Maris John M, Felsher Dean W, Hogenesch John B, Weljie Aalim M, Dang Chi V: MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells. Cell metabolism 22(6): 1009-19, Dec 2015.

Mickiewicz B, Kelly JJ, Ludwig TE, Weljie AM, Wiley JP, Schmidt TA, Vogel HJ: Metabolic analysis of knee synovial fluid as a potential diagnostic approach for osteoarthritis. J. Orthopaedic Res. 33: 1631-1638, November 2015 Notes: Article first published online : 12 JUN 2015, DOI: 10.1002/jor.22949.

Maguire SE, Rhoades S, Chen WF, Sengupta A, Yue Z, Lim JC, Mitchell CH, Weljie AM, Sehgal Amita: Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis. The Journal of Biological Chemistry 290(33): 20407-16, Aug 2015.

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Last updated: 10/06/2016
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