Aalim M. Weljie

faculty photo
Research Assistant Professor of Pharmacology
Member, Center of Excellence in Environmental Toxicology
Member, Institute of Translational Medicine and Therapeutics
Department: Pharmacology

Contact information
10-113 Smilow Center for Translational Research
3400 Civic Center Blvd, Bldg 421
Philadelphia, PA 19104
Office: 215-573-8085
Lab: 215-898-2220
B.Sc. (Chemistry; Certificate in Engineering)
Mount Allison University, 1996.
Ph.D. (Biochemistry)
University of Calgary, 2002.
Permanent link

Description of Itmat Expertise

Metabolomics, NMR spectroscopy, Mass spectrometry, multivariate statistical analysis

Description of Research Expertise

The Weljie Lab is located in the Department of Systems Pharmacology and Translational Therapeutics within the Perelman School of Medicine at the University of Pennsylvania. Our lab is at the forefront of metabolomics technologies to examine biological problems in a translational medicine context, particularly related to sleep and circadian rhythms.

Metabolomics is a growing sub-field of systems biology centered on the study of small biological molecules in biological fluids and tissues. Recent research suggests that analysis of metabolite concentrations in living systems is useful in disease diagnosis, prognosis, and predicting drug efficacy in a personalized medicine context.

There is an intrinsic link between metabolism and function of the innate circadian clock system in numerous organisms and disease states, but the exact mechanism by which the clock controls mammalian metabolism is poorly understood. Our work seeks to fill this knowledge gap along with a particular emphasis on understanding the relationship of the clock with cancer and environmental health.

Selected Publications

Mickiewicz B, Kelly JJ, Ludwig TE, Weljie AM, Wiley JP, Schmidt TA, Vogel HJ: Metabolic analysis of knee synovial fluid as a potential diagnostic approach for osteoarthritis. J. Orthopaedic Res. 33: 1631-1638, November 2015 Notes: Article first published online : 12 JUN 2015, DOI: 10.1002/jor.22949.

Maguire SE, Rhoades S, Chen WF, Sengupta A, Yue Z, Lim JC, Mitchell CH, Weljie AM, Sehgal Amita: Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis. The Journal of Biological Chemistry 290(33): 20407-16, Aug 2015.

Sengupta A, Harders E, Gehrman PW, Aalim M. Weljie: Estimation of brain response during sleep from serum metabolome by NMR spectroscopy. 21st Meeting of the National Magntic Resonance Society (India) March 2015 Notes: Oral.

Weljie AM, Meerlo P, Goel N, Sengupta A, Kayser MS, Abel T, Birnbaum MJ, Dinges DF, Sehgal A: Oxalic acid and diacylglycerol 36:3 are cross-species markers of sleep debt. Proceedings of the National Academy of Sciences of the United States of America 112(8): 2569-74, Feb 2015.

Thomas C, Krishnaiah SY, Rhoades S, Bolden S, Salek R, Weljie AM: Shooting blanks: optimizing mass spectrometery metabolomics methods via analysis of injection blank effects. Leadership Alliance National Symposium, Stamford CT. 2015 Notes: Oral.

Booth Sean C, Weljie Aalim M, Turner Raymond J: Metabolomics reveals differences of metal toxicity in cultures of Pseudomonas pseudoalcaligenes KF707 grown on different carbon sources. Frontiers in microbiology 6: 827, 2015.

Rhoades S, Weljie AM: 3D time-dependent fluxomics: probing metabolic flux across the circadian cycle using computational and experimental approaches. Metabolomics Society Annual Meeting 2015, San Francisco 2015.

Ubeydullah ER, Sengupta A, Harders E, Gehrman PW, Weljie AM: Brain response during sleep estimated from NMR metabolomics. Metabolomics-2015, Philadelphia, PA 2015.

Sengupta A, Harders E, Gehrman PW, Weljie AM: Brain Activity During Sleep: The Metabolic Connection. Metabolomics Society Annual Meeting 2015, San Francisco 2015.

Dang NT, Ahn BY, Senger DL, Weljie AM : The distinct role of fatty acid synthesis pathway on glioma metabolism and invasion. Cancer and Metabolism conference, Cambridge, UK 2015.

back to top
Last updated: 10/30/2015
The Trustees of the University of Pennsylvania