Carla R Scanzello

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Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Member, Penn Center for Musculoskeletal Disorders
Member, Penn Institute for Immunology
Member, Penn Institute for Translational Medicine and Therapeutics
Staff Physician, Philadelphia VA Medical Center
Department: Medicine

Contact information
Division of Rheumatology
University of Pennsylvania, School of Medicine
5th Floor White Bldg
3400 Spruce Street
Philadelphia, PA 19104
B.S. (Biochemistry)
University of Delaware, Newark, DE, 1991.
Temple University, School of Medicine, Philadelphia, PA, 2001.
Ph.D (Immunology & Microbiology)
Temple University, School of Medicine, Philadelphia, PA, 2001.
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Description of Itmat Expertise

My research focuses on the molecular stimuli and clinical consequences of synovial inflammation in early-stage osteoarthritis (OA) and meniscal injury. We have identified a set of inflammatory mediators that are over-expressed in patients with early-stage knee OA. These include sCD14, IL-15 and CCL19. We are now trying to understand how these mediators impact OA development or progression after joint injury, with the goal of developing novel anti-inflammatory strategies.

Using both in vitro and in vivo modeling, we investigate (1) how CD14 modulates synoviocyte Toll-like receptor (TLR) activity, and impacts OA development after meniscal injury; and (2) how IL-15 and CCL19 contribute to synoviocyte responses and progression of OA disease features. In addition, we collaborate on a longitudinal pilot study aimed at defining what the clinical impact of synovial inflammation is on post-surgical outcomes in the arthroscopic meniscectomy population at risk for OA.

Selected Publications

J Lieberthal, N Sambamurthy, CR Scanzello: Inflammation in Joint Injury and Post-Traumatic Osteoarthritis. Osteoarthritis Cartilage 2015 Notes: In Press.

Nair A, Gan J, Bush-Joseph C, Verma N, Tetreault MW, Saha K, Margulis A, Fogg L, Scanzello CR.: Synovial chemokine expression and relationship with knee symptoms in patients with meniscal tears. Osteoarthritis Cartilage 23(7): doi: 10.1016/j.joca.2015.02.016, Jul 2015.

Scanzello Carla R, Loeser Richard F: Inflammatory Activity in Symptomatic Knee Osteoarthritis: Not All Inflammation is Local. Arthritis & Rheumatology doi: 10.1002/art.39304, Aug 2015.

Scanzello Carla R, Markova Dessislava Z, Chee Ana, Xiu Yan, Adams Sherrill L, Anderson Greg, Zgonis Miltiadis, Qin Ling, An Howard S, Zhang Yejia: Fibronectin splice variation in human knee cartilage, meniscus and synovial membrane: observations in osteoarthritic knee. Journal of Orthopaedic Research 33(4): 556-62, Apr 2015.

J Kurkó, A Vida, TT Glant, CR Scanzello, RS Katz, A Nair, Z Szekanecz, K Mikecz: Identification of myeloid-derived suppressor cells in the synovial fluid of patients with rheumatoid arthritis: a pilot study. BMC Musculoskelet Disord 15: 281, 2014.

S Ritter, R Subbaiaih, G Bebek, J Crish, CR Scanzello, B Krastins, A Garces, D Sarracino, M Lopez, MK Crow, T Aigner, MB Goldring, SR Goldring, DM Lee, R Gobezie, AO Aliprantis: Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. Arthritis & Rheumatism 65: 981-92, 2013.

CR Scanzello, AS Albert, E DiCarlo, KB Rajan, V Kanda, EU Asomugha, BH Swaim, JN Katz, SR Goldring, JC Richmond, B McKeon. : The influence of synovial inflammation and hyperplasia on symptomatic outcomes up to two-years post-operatively in patients undergoing partial meniscectomy. Osteoarthritis Cartilage 21: 1392-9, 2013.

A Nair, V Kanda, C Bush-Joseph, N Verma, S Chubinskaya, K Mikecz, TT Glant, A-M Malfait, MK Crow, GT Spear, A Finnegan, CR Scanzello: "Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to TLR-4 and TLR-2 ligands via soluble CD14" Arthritis & Rheumatism 64: 2268-77, 2012.

CR Scanzello, B McKeon, BH Swaim, E DiCarlo, EU Asomugha, V Kanda, A Nair, DM Lee, JC Richmond, JN Katz, MK Crow, SR Goldring. : "Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship with symptoms" Arthritis & Rheumatism 63: 391-400, 2011.

Q Wang, AL Rozelle, CM Lepus, CR Scanzello, JJ Song, DM Larsen, JF Crish, G Bebek, SY Ritter, TM Lindstrom, I Hwang, HH Wong, L Punzi, A Encarnacion, M Shamloo, SB Goodman, T Wyss-Coray, SR Goldring, R Gobezie, MK Crow, VM Holers DM Lee, WH Robinson: "Identification of a central role for complement in osteoarthritis" Nature Medicine 17: 1674-9, 2011.

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Last updated: 09/25/2015
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