Carla R Scanzello

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Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Member, Penn Center for Musculoskeletal Disorders
Member, Institute for Translational Medicine and Therapeutics
Staff Physician, Philadelphia VA Medical Center
Department: Medicine

Contact information
Division of Rheumatology
University of Pennsylvania, School of Medicine
8th Floor Penn Tower
3400 Spruce Street
Philadelphia, PA 19104
Education:
B.S. (Biochemistry)
University of Delaware, Newark, DE, 1991.
M.D.
Temple University, School of Medicine, Philadelphia, PA, 2001.
Ph.D (Immunology & Microbiology)
Temple University, School of Medicine, Philadelphia, PA, 2001.
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Description of Itmat Expertise

My research focuses on the molecular stimuli and clinical consequences of synovial inflammation in early-stage osteoarthritis (OA) and meniscal injury. We have identified a set of inflammatory mediators that are over-expressed in patients with early-stage knee OA. These include sCD14, IL-15 and CCL19. We are now trying to understand how these mediators impact OA development or progression after joint injury, with the goal of developing novel anti-inflammatory strategies.

Using both in vitro and in vivo modeling, we investigate (1) how CD14 modulates synoviocyte Toll-like receptor (TLR) activity, and impacts OA development after meniscal injury; and (2) how IL-15 and CCL19 contribute to synoviocyte responses and progression of OA disease features. In addition, we collaborate on a longitudinal pilot study aimed at defining what the clinical impact of synovial inflammation is on post-surgical outcomes in the arthroscopic meniscectomy population at risk for OA.

Selected Publications

CR Scanzello, AS Albert, E DiCarlo, KB Rajan, V Kanda, EU Asomugha, BH Swaim, JN Katz, SR Goldring, JC Richmond, B McKeon. : The influence of synovial inflammation and hyperplasia on symptomatic outcomes up to two-years post-operatively in patients undergoing partial meniscectomy. Osteoarthritis Cartilage 21: 1392-9, 2013.

S Ritter, R Subbaiaih, G Bebek, J Crish, CR Scanzello, B Krastins, A Garces, D Sarracino, M Lopez, MK Crow, T Aigner, MB Goldring, SR Goldring, DM Lee, R Gobezie, AO Aliprantis: "Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues" Arthritis & Rheumatism 2013 Notes: in press.

WN Sankar, N Arden, YJ Kim, A Grodzinsky, L Sandell, CR Scanzello, and K Siebenrock: Staging of Hip Osteoarthritis for Clinical Trials on Femoroacetabular Impingement. J Am Acad Orth Surg 21 (Suppl 1): S33-8, 2013.

RF Loeser, SR Goldring, CR Scanzello, and MB Goldring.: "Osteoarthritis: A Disease of the Joint as an Organ" Arthritis & Rheumatism 64: 1697-1707, 2012.

CR Scanzello, SR Goldring: "The Role of Synovitis in Osteoarthritis Pathogenesis" Bone 51: 249-5, 2012.

CR Scanzello : Pathologic and Pathogenic Processes in Osteoarthritis: The Effects of Synovitis. HSS Journal 8: 20–22, 2012.

A Nair, V Kanda, C Bush-Joseph, N Verma, S Chubinskaya, K Mikecz, TT Glant, A-M Malfait, MK Crow, GT Spear, A Finnegan, CR Scanzello: "Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to TLR-4 and TLR-2 ligands via soluble CD14" Arthritis & Rheumatism 64: 2268-77, 2012.

Q Wang, AL Rozelle, CM Lepus, CR Scanzello, JJ Song, DM Larsen, JF Crish, G Bebek, SY Ritter, TM Lindstrom, I Hwang, HH Wong, L Punzi, A Encarnacion, M Shamloo, SB Goodman, T Wyss-Coray, SR Goldring, R Gobezie, MK Crow, VM Holers DM Lee, WH Robinson: "Identification of a central role for complement in osteoarthritis" Nature Medicine 17: 1674-9, 2011.

CR Scanzello, McKeon B, Swaim BH, DiCarlo E, Umoh E, Kanda V, Nair A, Lee DM, Richmond JC, Katz JN, Crow MK, Goldring SR: "Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship with symptoms" Osteoarthritis and Cartilage 2010 Notes: poster.

CR Scanzello, Umoh EM, Pessler F, Diaz-Torne C, Miles T, DiCarlo EF, Potter HG, Mandl LA, Marx R, Rodeo S, Goldring SR, Crow MK: "Local cytokine profiles in knee osteoarthritis: Elevated synovial fluid interleukin-15 differentiates early from end-stage disease" OA and Cartilage 17: 1040-8, 2009.

CR Scanzello, A Plaas, MK Crow: "Innate Immune System Activation in Osteoarthritis" Current Op Rheum 20: 565-72, 2008.

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Last updated: 01/27/2014
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