Carla R Scanzello

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Assistant Professor of Medicine at the Hospital of the University of Pennsylvania
Member, Penn Center for Musculoskeletal Disorders
Member, Penn Institute for Immunology
Member, Penn Institute for Translational Medicine and Therapeutics
Staff Physician, Philadelphia VA Medical Center
Department: Medicine

Contact information
Division of Rheumatology
University of Pennsylvania, School of Medicine
8th Floor Penn Tower
3400 Spruce Street
Philadelphia, PA 19104
Education:
B.S. (Biochemistry)
University of Delaware, Newark, DE, 1991.
Ph.D (Immunology & Microbiology)
Temple University, School of Medicine, Philadelphia, PA, 2001.
M.D.
Temple University, School of Medicine, Philadelphia, PA, 2001.
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Description of Itmat Expertise

My research focuses on the molecular stimuli and clinical consequences of synovial inflammation in early-stage osteoarthritis (OA) and meniscal injury. We have identified a set of inflammatory mediators that are over-expressed in patients with early-stage knee OA. These include sCD14, IL-15 and CCL19. We are now trying to understand how these mediators impact OA development or progression after joint injury, with the goal of developing novel anti-inflammatory strategies.

Using both in vitro and in vivo modeling, we investigate (1) how CD14 modulates synoviocyte Toll-like receptor (TLR) activity, and impacts OA development after meniscal injury; and (2) how IL-15 and CCL19 contribute to synoviocyte responses and progression of OA disease features. In addition, we collaborate on a longitudinal pilot study aimed at defining what the clinical impact of synovial inflammation is on post-surgical outcomes in the arthroscopic meniscectomy population at risk for OA.

Selected Publications

M Jolly, S Francis, R Aggarwal, R Mikolaitis, T Niewold, S Chubinskaya, J Block, C Scanzello, W Sequeira. : Serum free light chains, interferon-alpha, and interleukins in systemic lupus erythematosus. Lupus 23: 881-888, 2014.

N Ruel, DZ Markova, SL Adams, C Scanzello, G Cs-Szabo, D Gerard, P Shi, DG Anderson, M Zack, HS An, D Chen, Y Zhang. : Fibronectin Fragments and the Cleaving Enzyme ADAM-8 in the Degenerative Human Intervertebral Disc. Spine 39: 1274-9, 2014.

J Kurkó, A Vida, TT Glant, CR Scanzello, RS Katz, A Nair, Z Szekanecz, K Mikecz: Identification of myeloid-derived suppressor cells in the synovial fluid of patients with rheumatoid arthritis: a pilot study. BMC Musculoskelet Disord 15: 281, 2014.

S Ritter, R Subbaiaih, G Bebek, J Crish, CR Scanzello, B Krastins, A Garces, D Sarracino, M Lopez, MK Crow, T Aigner, MB Goldring, SR Goldring, DM Lee, R Gobezie, AO Aliprantis: Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. Arthritis & Rheumatism 65: 981-92, 2013.

CR Scanzello, AS Albert, E DiCarlo, KB Rajan, V Kanda, EU Asomugha, BH Swaim, JN Katz, SR Goldring, JC Richmond, B McKeon. : The influence of synovial inflammation and hyperplasia on symptomatic outcomes up to two-years post-operatively in patients undergoing partial meniscectomy. Osteoarthritis Cartilage 21: 1392-9, 2013.

A Nair, V Kanda, C Bush-Joseph, N Verma, S Chubinskaya, K Mikecz, TT Glant, A-M Malfait, MK Crow, GT Spear, A Finnegan, CR Scanzello: "Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to TLR-4 and TLR-2 ligands via soluble CD14" Arthritis & Rheumatism 64: 2268-77, 2012.

CR Scanzello, B McKeon, BH Swaim, E DiCarlo, EU Asomugha, V Kanda, A Nair, DM Lee, JC Richmond, JN Katz, MK Crow, SR Goldring. : "Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship with symptoms" Arthritis & Rheumatism 63: 391-400, 2011.

Q Wang, AL Rozelle, CM Lepus, CR Scanzello, JJ Song, DM Larsen, JF Crish, G Bebek, SY Ritter, TM Lindstrom, I Hwang, HH Wong, L Punzi, A Encarnacion, M Shamloo, SB Goodman, T Wyss-Coray, SR Goldring, R Gobezie, MK Crow, VM Holers DM Lee, WH Robinson: "Identification of a central role for complement in osteoarthritis" Nature Medicine 17: 1674-9, 2011.

CR Scanzello, Umoh EM, Pessler F, Diaz-Torne C, Miles T, DiCarlo EF, Potter HG, Mandl LA, Marx R, Rodeo S, Goldring SR, Crow MK: "Local cytokine profiles in knee osteoarthritis: Elevated synovial fluid interleukin-15 differentiates early from end-stage disease" OA and Cartilage 17: 1040-8, 2009.

F Pessler, L Dai, C Diaz-Torne, C Gomez-Vaquero, , ME Paessler, DH Zheng, E Einhorn, U Range, C Scanzello, HR Schumacher: "The synovitis of "non-inflammatory" orthopedic arthropathies: a quantitative histologic and immunohistochemical analysis. " Ann Rheum Dis 67: 1184-1187, 2008.

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Last updated: 10/16/2014
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