Deanne Taylor

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Research Assistant Professor of Pediatrics
Director, Bioinformatics Group, The Children's Hospital of Philadelphia, Department of Biomedical and Health Informatics, University of Pennsylvania
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
Biomedical and Health Informatics
3535 Market Street, Suite 1024
Philadelphia, PA 19104
Education:
AA (General Studies, Honors)
North Shore Community College, 1991.
BA (Physics, Astronomy)
Wellesley College, 1995.
MS (Biophysics)
University of Michigan, 1998.
PhD (Biophysics)
University of Michigan, 2001.
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Description of Itmat Expertise

Bioinformatics, single-cell biology, cell models, applications of cell models to studying pediatric diseases

Description of Research Expertise

Translational Computational Biology: Development of bioinformatics methods using mathematical and computational approaches to better understand the genetic contribution of biological variation to disease, coupling clinical information with high-dimensional biomedical data from next-gen sequencing, microarray, PCR, and proteomics experiments.

Computational Systems Biology: approaches to understanding the effects of genetic variation on developing biological systems through analysis of functional genomics studies and associated contributions to disease. Modeling of biological systems.

Bioinformatics: Machine-learning methods development and use. Next-generation sequence analysis. Microarray analysis. Database and knowledge management and data mining.

Genetics and genomics of development and reproduction.

Selected Publications

Sergei Spitsin, Pablo Tebas, Jeffrey S. Barrett, Vasiliki Pappa, Deborah Kim, Deanne Taylor, Dwight L. Evans and Steven D. Douglas : Anti-inflammatory effects of aprepitant co-administration with cART regimen containing ritonavir in HIV infected adults. JCI Insight 2(19): e95893, October 2017.

Agopian, Aaron J; Goldmuntz, Elizabeth; Hakonarson, Haakon; Sewda, H; Taylor, Deanne; Mitchell, Laura E; Consortium, Pediatric Cardiac Genomics: Genome-wide Association Studies and Meta-Analyses for Congenital Heart Defects. Circulation: Cardiovascular Genetics 10(3): e001449, May 2017.

de Torrente, Laurence, Zimmerman, Samuel, Taylor, Deanne, Hasegawa, Yu, Wells, Christine A., Mar, Jessica C: pathVar: a new method for pathway-based interpretation of gene expression variability. PeerJ 5(1): e3334, May 2017.

Alexandra L. Nguyen; Diego Marin; Anbo Zhou; Amanda S. Gentilello; Evan M. Smoak; Zubing Cao; Anastasia Fedick; Yujue Wang; Deanne Taylor; Richard T. Scott, Jr; Jinchuan Xing; Nathan Treff; Karen Schindler;: Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy Mol Hum Reprod 23(6): 406-416, April 2017.

Hongbo Michael Xie; Petra Werner; Dwight Stambolian; Joan E. Bailey-Wilson; Hakon Hakonarson; Peter S. White; Deanne M. Taylor; Elizabeth Goldmuntz: Rare copy number variants in patients with congenital conotruncal heart defects. Birth Defects Research 109(4): 271-295, March 2017.

Chandrashekar,Chandrika Sefcikova; Shellikeri, Annadanesh ; Chandrashekar, S; Taylor,Erika A; Taylor, Deanne M : Visualizing electromagnetic fields in metals by MRI. AIP Advances. AIP Publishing, 7(2): 025310, February 2017.

St Louis Sarah, Scott Richard, Lewis Christa, Salamon Charbel, Pagnillo Jennifer, Treff Nathan, Taylor Deanne, Culligan Patrick: Genetic Mutation that May Contribute to Failure of Prolapse Surgery in White Women: A Case-Control Study. Journal of Minimally Invasive Gynecology 23(5): 726-30, Jul-Aug 2016.

Irinia O. Vvedenskayaa, Hanif Vahedian-Movahedb, Yuanchao Zhang, Deanne M. Taylor, Richard H. Ebright, Bryce E. Nickels: Interactions between RNA polymerase and the core recognition element are a determinant of transcription start site selection. Proceedings of the National Academy of Sciences 113(21): E2899-905, May 2016.

Treff Nathan R, Krisher Rebecca L, Tao Xin, Garnsey Heather, Bohrer Chelsea, Silva Elena, Landis Jessica, Taylor Deanne, Scott Richard T, Woodruff Teresa K, Duncan Francesca E: Next Generation Sequencing-Based Comprehensive Chromosome Screening in Mouse Polar Bodies, Oocytes, and Embryos. Biology of Reproduction 94(4): 76, Apr 2016.

Jared T. Winkelman, Irina O. Vvedenskaya, Yuanchao Zhang, Yu Zhang, Jeremy G. Bird, Deanne M. Taylor, Richard L. Gourse, Richard H. Ebright, Bryce E. Nickels: Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection. Science. AAAS, 351(6277): 1090-1093, March 2016.

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Last updated: 11/28/2017
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