Deanne Taylor

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Research Assistant Professor of Pediatrics
Director, Bioinformatics Group, The Children's Hospital of Philadelphia, Department of Biomedical and Health Informatics, University of Pennsylvania
Department: Pediatrics

Contact information
The Children's Hospital of Philadelphia
Biomedical and Health Informatics
3535 Market Street, Suite 1024
Philadelphia, PA 19104
Education:
AA (General Studies, Honors)
North Shore Community College, 1991.
BA (Physics, Astronomy)
Wellesley College, 1995.
MS (Biophysics)
University of Michigan, 1998.
PhD (Biophysics)
University of Michigan, 2001.
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Description of Itmat Expertise

Bioinformatics, single-cell biology, cell models, applications of cell models to studying pediatric diseases

Description of Research Expertise

Translational Computational Biology: Development of bioinformatics methods using mathematical and computational approaches to better understand the genetic contribution of biological variation to disease, coupling clinical information with high-dimensional biomedical data from next-gen sequencing, microarray, PCR, and proteomics experiments.

Computational Systems Biology: approaches to understanding the effects of genetic variation on developing biological systems through analysis of functional genomics studies and associated contributions to disease. Modeling of biological systems.

Bioinformatics: Machine-learning methods development and use. Next-generation sequence analysis. Microarray analysis. Database and knowledge management and data mining.

Genetics and genomics of development and reproduction.

Selected Publications

Vvedenskaya IO, Bird JG, Zhang Y, Zhang Y, Jiao X, Barvík I,Krásný L, Kiledjian M, Taylor D, Ebright H, Nickels B. : CapZyme-Seq Comprehensively Defines Promoter-Sequence Determinants for RNA 5′ Capping with NAD+ Molecular Cell 70(3): 553–564.e9, May 2018.

Manti Guha, Satish Srinivasan, Pichai Raman, Yuefu Jiang, Brett A Kaufman, Deanne Taylor, Dawei Dong, Rumela Chakrabarti, Martin Picard, Russ P Carstens, Yuko Kijima, Mike Feldman, Narayan G Avadhani: Aggressive triple negative breast cancers have unique molecular signature on the basis of mitochondrial genetic and functional defects. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1864(4 Pt A): 1060-1071, April 2018.

RS Zimmerman, X Tao, D Marin, MD Werner, KH Hong, A Lonczak, J Landis, D Taylor, Y Zhan, R T Scott, N R Treff: Preclinical validation of a targeted next generation sequencing-based comprehensive chromosome screening methodology in human blastocysts. MHR: Basic science of reproductive medicine 24(1): 37-45, November 2017.

Sergei Spitsin, Pablo Tebas, Jeffrey S. Barrett, Vasiliki Pappa, Deborah Kim, Deanne Taylor, Dwight L. Evans and Steven D. Douglas : Anti-inflammatory effects of aprepitant co-administration with cART regimen containing ritonavir in HIV infected adults. JCI Insight 2(19): e95893, October 2017.

AJ Agopian, Elizabeth Goldmuntz, Haakon Hakonarson, H. Sewda, Deanne Taylor, Laura E Mitchell, Pediatric Cardiac Genomics Consortium : Genome-wide Association Studies and Meta-Analyses for Congenital Heart Defects. Circulation: Cardiovascular Genetics 10(3): e001449, May 2017.

Laurence de Torrente, Samuel Zimmerman, Deanne Taylor, Yu Hasegawa, Christine A. Wells, Jessica C. Mar: pathVar: a new method for pathway-based interpretation of gene expression variability. PeerJ 5(1): e3334, May 2017.

Alexandra L. Nguyen, Diego Marin, Anbo Zhou, Amanda S. Gentilello, Evan M. Smoak, Zubing Cao, Anastasia Fedick, Yujue Wang, Deanne Taylor, Richard T. Scott, Jr, Jinchuan Xing, Nathan Treff, Karen Schindler: Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy Mol Hum Reprod 23(6): 406-416, April 2017.

Hongbo Michael Xie, Petra Werner, Dwight Stambolian, Joan E. Bailey-Wilson, Hakon Hakonarson, Peter S. White, Deanne M. Taylor, Elizabeth Goldmuntz: Rare copy number variants in patients with congenital conotruncal heart defects. Birth Defects Research 109(4): 271-295, March 2017.

Chandrika Sefcikova Chandrashekar, Annadanesh Shellikeri, S Chandrashekar, Erika A Taylor, Deanne M Taylor: Visualizing electromagnetic fields in metals by MRI. AIP Advances. AIP Publishing, 7(2): 025310, February 2017.

Sarah St Louis, Richard Scott, Christa Lewis, Charbel Salamon, Jennifer Pagnillo, Nathan Treff, Deanne Taylor, Patrick Culligan: Genetic Mutation that May Contribute to Failure of Prolapse Surgery in White Women: A Case-Control Study. Journal of Minimally Invasive Gynecology 23(5): 726-30, Jul-Aug 2016.

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Last updated: 05/08/2018
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