Hans E. Huber

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Adjunct Associate Professor of Pharmacology
Department: Pharmacology

Contact information
213 Abbey Lane
Lansdale, PA
Education:
M.S. (Microbiology)
Swiss Federal Institute of Technology (ETH), Zürich, 1977.
Ph.D. (Biochemistry)
Swiss Federal Institute of Technology (ETH), Zürich , 1982.
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Description of Itmat Expertise

Targeted delivery of intracellular macromolecular therapeutics

Selected Publications

Zhang, N et al: Glycoengineered Pichia produced anti-HER2 is comparable to trastuzumab in preclinical study. mAbs 3: 289-298, 2011.

Cherrin C et al: An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo. Cancer Biol. Ther. 9: 493-503, 2010.

Aste-Amezaga, M et al: Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors. PLoS ONE 5: e9094, 2010.

Cox C D et al: Kinesin spindle protein (KSP) inhibitors. J. Med. Chem. 51: 4239-4252, 2008.

She Q-B et al: Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling. PLoS ONE 3: e3065, 2008.

DeFeo-Jones D et al: Tumor cell sensitization to apoptotic stimuli by selective inhibition of specific Akt/PKB family members. Mol. Cancer Ther. 4: 271-279, 2005.

Barnett S F et al: Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem. J. 385: 399-408, 2005.

Yan Y et al: Inhibition of a mitotic motor protein: where, how, and conformational consequences. J. Mol. Biol. 335: 547-554, 2004.

Huber H E et al: Retinoblastoma protein reverses DNA bending by transcription factor E2F. J. Biol. Chem. 269: 6999-7005 1994.

Huber H E and Richardson C C: Processing of the primer for plus-strand DNA synthesis by HIV-1 reverse transcriptase. J. Biol. Chem. 265: 10565-10573 1990.

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Last updated: 09/05/2017
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