Alexander C. Wright

faculty photo
Research Associate Professor of Radiology
Deputy Director, Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania School of Medicine
Technical Director, Micro-CT Scanner, Department of Radiology, University of Pennsylvania School of Medicine
Department: Radiology

Contact information
Radiology, 1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-349-5295
Fax: 215-662-7263
Education:
B.S. (Physics)
Georgia Institute of Technology, 1986.
Ph.D. (Physics)
Georgia Institute of Technology, 1991.
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Description of Research Expertise

Dr. Wright’s research involves the development of micro-MRI and micro-CT hardware, acquisition strategies and quantitative methods for the purpose of imaging the microstructure of biological tissues at cellular resolution. This includes the design and construction of novel and optimized radio-frequency and gradient coils for micro-MRI, and the development of quantitative image acquisition and analysis techniques for the characterization of tissue micro-architecture using both micro-MRI and micro-CT. Current focus is on developing micro-MRI methods for imaging the intervertebral disc ex vivo in order to measure collagen fiber architecture in the annulus fibrosus of the disc. In addition, micro-CT techniques are being developed for imaging and characterizing structural phenotypes in both soft-tissue and calcified specimens at extremely high resolution (1-10 µm isotropic). Another research effort involves the design, construction and implementation of transmit-receive RF coils for in vivo MRI of bone in the human tibia, using a whole-body 7 Tesla MRI scanner.

Description of Itmat Expertise

Development of micro-MRI and micro-CT hardware, acquisition strategies and quantitative methods for imaging micro-structure of biological tissues at cellular resolution.

Selected Publications

J. Huang, T. Wang, A. C. Wright, J. Yang, S. Zhou, L. Li, J. Yang, A. Small, M. S. Parmacek: Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development. Proceedings of the National Academy of Sciences, USA 112(14): 4447-4452, April 2015.

J. E. McDonough, L. Knudsen, A. C. Wright, W. M. Elliott, M. Ochs, J. C. Hogg: MicroCT measurement of alveolar number shows alveolar density is related to lung height in human lungs. Journal of Applied Physiology (1985) April 2015 Notes: doi: 10.1152/japplphysiol.01017.2014. [Epub ahead of print]

C. S. Rajapakse, M. Bashoor-Zadeh, C. Li, W. Sun, A. C. Wright, F. W. Wehrli: Volumetric cortical bone porosity assessment with MR imaging: validation and clinical feasibility. Radiology March 2015 Notes: Mar 19:141850. [Epub ahead of print]

J. H. Yoder, J. M. Peloquin, G. Song, N. J. Tustison, S. M. Moon, A. C. Wright, E. J. Vresilovic, J. C. Gee, D. M. Elliott: Internal three-dimensional strains in human intervertebral discs under axial compression quantified noninvasively by magnetic resonance imaging and image registration. Journal of Biomechanical Engineering 136(11): 111008 (9 pages), November 2014.

D. H. Cortes, J. F. Magland, A. C. Wright, D. M. Elliott: The shear modulus of the nucleus pulposus measured using magnetic resonance elastography: A potential biomarker for intervertebral disc degeneration. Magnetic Resonance in Medicine 72(1): 211-219, July 2014.

J. M. Peloquin, J. H. Yoder, N. T. Jacobs, S. M. Moon, A. C. Wright, E. J. Vresilovic, D. M. Elliott: Human L3L4 intervertebral disc mean 3D shape, modes of variation, and their relationship to degeneration. Journal of Biomechanics 47(10): 2452-2459, July 2014.

A. C. Seifert, C. Li, C. S. Rajapakse, M. Bashoor-Zadeh, Y. A. Bhagat, A. C. Wright, B. S. Zemel, A. Zavaliangos, F. W. Wehrli: Bone mineral (31)P and matrix-bound water densities measured by solid-state (31)P and (1)H MRI. NMR in Biomedicine 27(7): 739-748, July 2014.

A. C. Seifert, A. C. Wright, S. L. Wehrli, H. H. Ong, C. Li, F. W. Wehrli: 31P NMR relaxation of cortical bone mineral at multiple magnetic field strengths and levels of demineralization. NMR in Biomedicine 26(9): 1158-1166, September 2013.

S. M. Moon, J. H. Yoder, A. C. Wright, L. J. Smith, E. J. Vresilovic, D. M. Elliott: Evaluation of intervertebral disc cartilaginous endplate structure using magnetic resonance imaging. European Spine Journal 22(8): 1820-1828, August 2013.

M. Damek-Poprawa, S. Both, A. C. Wright, A. Maity, S. O. Akintoye: Onset of mandible and tibia osteoradionecrosis: a comparative pilot study in the rat. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 115(2): 201-211, February 2013.

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Last updated: 05/11/2015
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