Alexander C. Wright

faculty photo
Research Associate Professor of Radiology
Deputy Director, Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania School of Medicine
Technical Director, Micro-CT Scanner, Department of Radiology, University of Pennsylvania School of Medicine
Director of Imaging Core, Penn Center for Musculoskeletal Disorders
Department: Radiology

Contact information
Radiology, 1 Silverstein
3400 Spruce Street
Philadelphia, PA 19104
Office: 215-349-5295
Fax: 215-662-7263
Education:
B.S. (Physics)
Georgia Institute of Technology, 1986.
Ph.D. (Physics)
Georgia Institute of Technology, 1991.
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Description of Research Expertise

Dr. Wright’s research involves the development of micro-MRI and micro-CT hardware, acquisition strategies and quantitative methods for the purpose of imaging the microstructure of biological tissues at cellular resolution. This includes the design and construction of novel and optimized radio-frequency and gradient coils for micro-MRI, and the development of quantitative image acquisition and analysis techniques for the characterization of tissue micro-architecture using both micro-MRI and micro-CT. Current focus is on developing micro-MRI methods for imaging the intervertebral disc ex vivo in order to measure collagen fiber architecture in the annulus fibrosus of the disc. In addition, micro-CT techniques are being developed for imaging and characterizing structural phenotypes in both soft-tissue and calcified specimens at extremely high resolution (1-10 µm isotropic). Another research effort involves the design, construction and implementation of transmit-receive RF coils for in vivo MRI of bone in the human tibia, using a whole-body 7 Tesla MRI scanner.

Description of Itmat Expertise

Development of micro-MRI and micro-CT hardware, acquisition strategies and quantitative methods for imaging micro-structure of biological tissues at cellular resolution.

Selected Publications

M. Damek-Poprawa, S. Both, A. C. Wright, A. Maity, S. O. Akintoye: Onset of mandible and tibia osteoradionecrosis: a comparative pilot study in the rat. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology 115: 201-211, 2013.

D. H. Cortes, J. F. Magland, A. C. Wright, D. M. Elliott: The shear modulus of the nucleus pulposus measured using magnetic resonance elastography: A potential biomarker for intervertebral disc degeneration. Magnetic Resonance in Medicine, doi:10.1002/mrm.24895. [Epub ahead of print] 2013.

A. C. Seifert, A. C. Wright, S. L. Wehrli, H. H. Ong, C. Li, F. W. Wehrli: 31P NMR relaxation of cortical bone mineral at multiple magnetic field strengths and levels of demineralization. NMR in Biomedicine 26: 1158-1166, 2013.

H. H. Ong, A. C. Wright, F. W. Wehrli: Deuterium nuclear magnetic resonance unambiguously quantifies pore and collagen-bound water in cortical bone. Journal of Bone and Mineral Research 27: 2573-2581, 2012.

S. A. Chakkalakal, D. Zhang, A. L. Culbert, M. R. Convente, R. J. Caron, A. C. Wright, A. D. Maidment, F. S. Kaplan, E. M. Shore: An Acvr1 R206H knock-in mouse has fibrodysplasia ossificans progressiva. Journal of Bone and Mineral Research 27: 1746-1756, 2012.

J. E. McDonough, R. Yuan, M. Suzuki, N. Seyednejad, W. M. Elliott, P. G. Sanchez, A. C. Wright, W. B. Gefter, L. Litzky, H. O. Coxson, P. D. Paré, D. D. Sin, R. A. Pierce, J. C. Woods, A. M. McWilliams, J. R. Mayo, S. C. Lam, J. D. Cooper, J. C. Hogg: Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. The New England Journal of Medicine 365(17): 1567-1575, October 2011.

P. Tsao, V. Arora, M. Q. Ji, A. C. Wright, R. Eisenberg: KRN/I-Ag7 mouse arthritis is independent of complement C3. Journal of Clinical Immunology 2011 Notes: Published online: 06 July 2011.

Y. A. Bhagat, C. S. Rajapakse, J. F. Magland, J. H. Love, A. C. Wright, M. J. Wald, H. K. Song, F. W. Wehrli: Performance of µMRI-based virtual bone biopsy for structural and mechanical analysis at the distal tibia at 7T field strength. Journal of Magnetic Resonance Imaging 33: 372-381, 2011.

A. C. Wright, R. Lemdiasov, T. J. Connick, Y. A. Bhagat, J. F. Magland, H. K. Song, S. P. Toddes, R. Ludwig, F. W. Wehrli: Helmholtz-pair transmit coil with integrated receive array for high-resolution MRI of trabecular bone in the distal tibia at 7 T. Journal of Magnetic Resonance 210: 113-122, 2011.

J. F. Magland, C. S. Rajapakse, A. C. Wright, R. Acciavatti, F. W. Wehrli: 3D fast spin echo with out-of-slab cancellation - A technique for high-resolution structural imaging of trabecular bone at 7 Tesla. Magnetic Resonance in Medicine 63: 719-727, 2010.

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Last updated: 11/21/2013
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