Jonathan P. Katz

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Associate Professor of Medicine
Director, Undergraduate Student Scholars Program, Gastroenterology Division , University of Pennsylvania School of Medicine
Director, Molecular Pathology and Imaging Core, NIH Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania School of Medicine
Associate Director, Gastroenterology Fellowship Training Program, University of Pennsylvania
Member, Abramson Cancer Center, University of Pennsylvania
Member, Skin Disease Research Core Center, University of Pennsylvania Perelman School of Medicine
Member, Penn Institute for Regenerative Medicine, University of Pennsylvania Perelman School of Medicine
Member, Institute for Translational Medicine and Therapeutics (ITMAT), University of Pennsylvania Perelman School of Medicine
Department: Medicine

Contact information
913 Biomedical Research Building II/III
421 Curie Boulevard
Philadelphia, PA 19104-4863
Office: 215-746-7780
Fax: 215-573-2024
Graduate Group Affiliations
A.B. (Chemistry)
Columbia University, Columbia College , 1988.
University of Chicago, Pritzker School of Medicine, 1993.
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Description of Research Expertise

Research Interests
Transcriptional regulation
Epithelial homeostasis
Gastrointestinal carcinogenesis

Key words: gastrointestinal cancer, Krüppel-like factors, proliferation, differentiation

Description of Research
My research focuses on analyses of gastrointestinal proliferation, differentiation, and malignant transformation. Recently, my laboratory has concentrated on KLF4 and KLF5, two related Krüppel-like factor (KLF) family members highly expressed in the gastrointestinal epithelia. KLF4 and KLF5 are important regulators of cellular proliferation and differentiation both in vitro and in vivo. Numerous studies implicate these factors in carcinogenesis in a number of tissues and cell types. Using tissue-specific gene ablation and transgenic approaches, we have generated a number of mouse models to investigate the function of Klf4 and Klf5 in development and gastrointestinal epithelial homeostasis in vivo. These mouse models are complemented by novel in vitro model systems, using primary esophageal cells in two-dimensional culture and three-dimensional organotypic culture. These experiments allow us to dissect the molecular mechanisms regulating gastrointestinal epithelial homeostasis, including the role of epithelial-mesenchymal interactions. Using these in vitro and in vivo models, we are examining the specific factors which control the balance between proliferation and differentiation in gastrointestinal epithelia and the elements which disrupt this balance during mucosal injury and carcinogenesis.

Rotation Projects
Several rotation projects are available in the laboratory based upon applicant interests. Please contact Dr. Katz directly to discuss potential projects.

Lab personnel:
Jonathan Katz, MD – Principal Investigator
Yizeng Yang, MD, PhD - Senior Research Investigator
Marie-Pier Tetreault, PhD - Research Associate
Daniel Weinblatt - Research Specialist

Administrative Assistant:
Hayley Sharpe
Phone: 215-898-0850

Description of Itmat Expertise

My research focuses on the specific transcription factors and signaling pathways that regulate normal gastrointestinal epithelial homeostasis and how these factors and pathways are perturbed in gastrointestinal diseases including cancer. As such, we seek to identify new diagnostic and therapeutic targets for gastrointestinal diseases.

Selected Publications

Tetreault, M.P., Yang, Y., Katz, J.P: Krüppel-like factors in cancer. Nature Reviews Cancer 13(10): 701-13, Oct 2013.

Tarapore, R.S., Yang, Y., Katz, J.P.: Restoring KLF5 in Esophageal Squamous Cell Cancer Cells Activates the JNK Pathway Leading to Apoptosis and Reduced Cell Survival. Neoplasia 15(5): 472-80, May 2013.

Yang, Y., Tarapore, R.S., Jarmel, M.H., Tetreault, M.P., Katz, J.P.: p53 mutation alters the effect of the esophageal tumor suppressor KLF5 on keratinocyte proliferation. Cell Cycle 11(21), Sep 2012.

Tetreault, M.P., Alrabaa, R., McGeehan, M., Katz, J.P. : Krüppel-like factor 5 protects against murine colitis and activates JAK-STAT signaling in vivo. PLoS One 7(5): e38338, May 2012.

Yang, Y., Nakagawa, H., Tetreault, M.P., Billig, J., Victor, N., Goyal, A., Sepulveda, A.R., Katz, J.P.: Loss of transcription factor KLF5 in the context of p53 ablation drives invasive progression of human squamous cell cancer. Cancer Research 71(20): 6475-84, Oct 2011.

Tetreault, M.P., Yang, Y., Travis, J., Yu, Q.C., Klein-Szanto, A., Tobias, J.W., Katz, J.P.: Esophageal squamous cell dysplasia and delayed differentiation with deletion of Krüppel-like factor 4 in murine esophagus. Gastroenterology 139(1): 171-81.e9, Jul 2010.

Tetreault, M.P., Wang, M.L., Yang, Y., Travis, J., Yu, Q.C., Klein-Szanto, A., Katz, J.P.: Klf4 overexpression activates epithelial cytokines and inflammation-mediated esophageal squamous cell cancer in mice. Gastroenterology 139(6): 2124-2134.e9, Dec 2010.

Yang, Y., Tetreault, M.P., Yermolina, Y., Goldstein, B.G., Katz, J.P.: Krüppel-like factor 5 controls keratinocyte migration via the integrin-linked kinase. Journal of Biological Chemistry 283: 18812-20, 2008.

Yang, Y., Goldstein, B.G., Nakagawa, H., Katz, J.P.: Krüppel-like factor 5 activates MEK/ERK signaling via EGFR in primary squamous epithelial cells. FASEB Journal 21: 543-50, 2007.

Yang, Y., Goldstein, B.G., Chao, H., Katz, J.P.: KLF4 and KLF5 regulate proliferation, apoptosis, and invasion in esophageal cancer cells. Cancer Biology and Therapy 4: 1216-21, 2005.

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Last updated: 02/05/2015
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