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Itzhak Nissim

Research Professor of Pediatrics
Department: Pediatrics

Contact information
Division of Developmental and Behavioral Pediatrics
Philadelphia, PA 19104
Office: 2155903392
Fax: 2155905199
B.Sc. (Life Science)
Bar Ilan University, Ramat Gan, Israel , 1972.
M.Sc. (Life Science)
Hebrew University, Jerusalem, Israel, 1974.
Ph.D. (Life Science)
Weizmann Institute of Science, Rehovot, Israel, 1979.
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Description of Research Expertise

For over thirty years, I have been involved in the investigation of metabolic diseases, including defects in the hepatic urea cycle and ammonia detoxification, obesity, fatty liver disease, fatty acid oxidation, diabetes, and normal and pathogenic mitochondrial integrity and function. A special emphasis is on development of pharmacotherapeutic interventions to mitigate metabolic derangements of diverse origin. As a director of the Metabolomic Core Facility at CHOP, I have been involved in many projects investigating metabolomic profiling in normal and disease states and in teaching and training new fellow investigators in the field of metabolism.

Description of Other Expertise

As a director of the Metabolomic Core Facility at CHOP, I have been involved in teaching and training graduate students and new fellow investigators in the field of metabolism. I also, have collaborated and contributed to many investigators studying metabolomic profiling in normal and disease states.
As a member of the Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine as well as an adjunct professor of Biochemistry and Biophysics, Univ. of Penn, I have consulted in various projects dealing with hepatic metabolism, insulin resistance, obesity or diabetes.

Selected Publications

Kasumov T., Comte B, Puchowicz M. A., Brunengraber L., Jobbins K., Thomas K., Puchowicz MA, David F., Kinman P., Wherli S., Dahms W., Kerr D., Nissim I., Brunengraber H.: New secondary metabolites of phenylbutyrate in humans and rat. Drug Met. & Disposition 32: 1-10, 2004.

Welbourne T, and Nissim I: Acidosis and amino acid metabolism Metabolic & Therapeutic Aspect of Amino Acids in Clinical Nutrition, 2nd edition. Luc A (eds.). CRC Press, Page: 375-388, 2004.

Yudkoff M, Daikhin Y, Nissim I, Horyn O, Lazarow A, Nissim I: Metabolism of brain amino acids following pentylenetetrazole treatment. Epilepsy Res 53(1-2): 151-162, 2003.

Welbourne TC, Friday E, Fowler R, Turturro F, Nissim I: Troglitazone acts by PPAR{gamma} and PPAR{gamma}-independent pathways on LLC-PK1-F+ acid-base metabolism. Am J Physiol Renal Physiol September 2003 Notes: Epub ahead of print.

Nissim I, Horyn O, Luhovyy B, Lazarow A, Daikhin Y, Nissim I, Yudkoff M.: Role of the glutamate dehydrogenase reaction in furnishing aspartate nitrogen for urea synthesis: studies in perfused rat liver with 15N. Biochem J 376: 179-188, 2003.

Comte B, Kasumov T, Pierce BA, Puchowicz MA, Scott ME, Dahms W, Kerr D, Nissim I, Brunengraber H.: Identification of phenylbutyrylglutamine, a new metabolite of phenylbutyrate metabolism in humans. J Mass Spectrom 37(6): 581-590, 2002.

Brosnan JT, Brosnan ME, Nissim I: Application of 15N to the study of hepatic nitrogen metabolism. Adv Enzyme Regul 42: 305-315, 2002.

Coates G, Nissim I, Battarbee H, Welbourne T: Glitazones regulate glutamine metabolism by inducing a cellular acidosis in MDCK cells. Am J Physiol Endocrinol Metab 283(4): E729-E737, 2002.

Nissim I, Horyn O, Daikhin Y, Nissim I, Lazarow A, Yudkoff M: Regulation of urea synthesis by agmatine in the perfused liver: studies with 15N. Am J Physiol Endocrinol Metab 283(6): E1123-E1134, 2002.

Feldkamp T, Kribben A, Nissim I, Weinberg J.M, M.A. Venkatschalam: Dependence of proximal tubule (PT) energetics on mitochondrial complex I and its relation to energetic failure after hypoxia/reoxygenation (H/R). J AM SOC NEPHROL 13(Suppl. S): 321A, September 2002.

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Last updated: 12/12/2013
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