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Itzhak Nissim, Ph.D.

Adjunct Professor of Pediatrics (Human Genetics)
Department: Pediatrics

Contact information
Children's Hospital of Philadelphia
Division of Metabolism and Genetic
34th & Civic Center Blvd
Philadelphia, PA 19104
Office: 6107152989
B.Sc. (Life Science)
Bar Ilan University, Ramat Gan, Israel , 1972.
M.Sc. (Life Science)
Hebrew University, Jerusalem, Israel, 1974.
Ph.D. (Life Science)
Weizmann Institute of Science, Rehovot, Israel, 1979.
Post-Graduate Training
Department of Biochemistry, Bar Ilan Unviersity, Ramat Gan, Israel, 1969-1971.
Department of Food Technology, Institute of Agriculture, Bet Dagan, Israel, 1971-1973.
Department of Anatomy and Physiology, Hebrew University, Rehovot, Israel, 1973-1975.
Department of Isotope Research, Weizmann Institute of Science, Rehovot, Israel, 1975-1979.
Research Fellow, CHOP; University of Pennsylvania School of Medicine, 1979-1981.
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Description of Research Expertise

A pioneer and internationally prominent scientist in the application of stable isotopes to study metabolism. A long-standing scientific research focus on understanding the cause, mechanism(s) and outcome of metabolic disorders. The outcome of the research activity has profoundly alter the way we study disease processes as well as understanding the mechanism of metabolic malfunction in cases such as cancer, fatty liver disease, Metabolic Syndrome, neurological function, etc. Exemplar projects of the scientific endeavors including: (i) the mechanism(s) of hepatic metabolic dysfunction and exploration of metabolome/fluxome malfunction in Metabolic Syndrome;(ii) pathogenesis of disorders of mitochondrial integrity and function; (iii) brain metabolic functions and neurochemical aberrations; (iv) the molecular and metabolomic characteristics of cancer cells, etc.

Description of Other Expertise

As a scientific director of the Metabolomics Core Facility at Children’s Hospital of Philadelphia, I have collaborated and contributed to many projects investigating metabolomic and fluxomic profiling in normal and disease states. The Metabolomics core has been internationally recognized as metabolomics research center. The core provided state-of-the-art scientific and analytical services to CHOP and Penn investigators as well as to investigators from numerous academic centers in the U.S, Canada and Europe.
As a member of the Institute of Diabetes, Obesity and Metabolism, Perelman School of Medicine, I have been involved in various projects dealing with hepatic metabolism and insulin resistance, obesity or diabetes.

Selected Publications

Bo Li, Bo Qiu, David S.M. Lee, Zandra E. Walton, Joshua D. Ochocki, Lijoy K. Mathew, Anthony Mancuso, Terence P.F. Gade, Brian Keith, Itzhak Nissim, and M. Celeste Simon: Fructose-1,6-bisphosphatase opposes renal carcinoma progression. Nature 513(7517): 251-255, September 12 2014.

Nissim I, Horyn O, Daikhin Y, Li C, Chen P, Wherli Z. Nissim Ilana and Yudkoff M: The Molecular and Metabolic Influence of Long Term Agmatine Consumption. J Biol Chem. 289(14): 9710-9729, 04 2014.

Li C, Liu C, Nissim I, Chen J, Chen P, Doliba N, Zhang T, Nissim I, Daikhin Y, Stokes D, Yudkoff M, Bennett MJ, Stanley CA, Matschinsky FM, Naji A.: Regulation of glucagon secretion in normal and diabetic human islets by γ-hydroxybutyrate and glycine. J. Biol. Chem. 288(3): 3938-3951, 2013.

Cang C, Zhou Y, Navarro B, Seo YJ, Aranda K, Shi L, Battaglia-Hsu S, Nissim I, Clapham DE, Ren D.: mTOR regulates lysosomal ATP-sensitive two-pore Na(+) channels to adapt to metabolic state. Cell 152(4): 778-790, 2013.

Nissim I, Horyn O, Ilana Nissim, Daikhin Y, Wehrl SL,Yudkoff M and Matschinsky FM: : Effects of a glucokinase activator onhepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics. Biochem J. 444: 537-551, 2012.

Changhong Li, Chengyang Liu, Itzhak Nissim , et al.: : Regulation of Glucagon Secretion in Normal and Diabetic Human Islets by Gamma-Hydroxybutyrate and Glycine. J Biol Chem, 2012.

Falk MJ, Polyak E, Zhang Z, Peng M, King R, Maltzman JS, Okwuego E, Horyn O, Nakamaru-Ogiso E, Ostrovsky J, Xie LX, Chen JY, Marbois B, Nissim I, Clarke CF, Gasser DL: Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice. EMBO Mol Med. 7: 410-427, 2011.

Nissim I, Horyn O, Nissim I, Daikhin Y, Caldovic L, Barcelona B, Cervera J, Tuchman M,Yudkoff M.: Down-regulation of hepatic urea synthesis by oxypurines: xanthine and uric acid inhibit N-acetylglutamate synthase. J Biol Chem. 286: 22055-22068, 2011.

Li C, Chen P, Palladino A, Narayan S, Russell LK, Sayed S, Xiong G, Chen J, Stokes D, Butt YM, Jones PM, Collins HW, Cohen NA, Cohen AS, Nissim I, Smith TJ, Strauss AW, Matschinsky FM, Bennett MJ, Stanley CA. : Mechanism of hyperinsulinism in short-chain 3- hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase. J Biol Chem. 285: 1806-1818, 2010.

Nissim I, , Horyn O, Daikhin Y, Nissim I, Luhovyy B., Phillips, PC, and Yudkoff M.: Ifosfamide-Induced Nephrotoxicity: Mechanism and Prevention Cancer Res. 66 66: 7824-7831, 2006.

Yudkoff M, Ah Mew N, Daikhin Y, Horyn O, Nissim I, Nissim I, Payan I, Tuchman M. : Measuring in vivo ureagenesis with stable isotopes. Mol Genet Metab. 100: 37-41, 2010.

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Last updated: 08/19/2023
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