faculty photo

Allan I. Pack

John Miclot Professor
Department: Medicine

Contact information
Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
Graduate Group Affiliations
Education:
M.B.Ch.B
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
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Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Description of Clinical Expertise

Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).

Selected Publications

Pak, V.M., Dai, F., Keenan, B.T., Gooneratne, N. and Pack, A.I.: Lower plasma choline levels are associated with sleepiness symptoms. Sleep Medicine 2017 (in press) Notes: https://doi.org/10.1016/j.sleep.2017.10.004.

Jain, S., Gurubhagavatula, I, Townsend, R., Kuna, S.T., Teff, K, Wadden, T.a., Chittams, J., Hanlon, A.L., Maislin, G., Saif, H., Broderick, P., Ahmad, Z., Pack, A.I. and Chirinos, J.A.: Effect of CPAP, weight loss, or CPAP plus weight loss on central hemodynamics and arterial stiffness. Hypertension 70(6): 1283-1290, Dec 2017.

Chirinos, D.A., Gurubhagavatula, I., Broderick, P., Chirinos, J.A., Teff, K., Wadden, T., Maislin, G., Saif, H., Chittams, J., Cassidy, C., Hanlon, A.L. and Pack, A.I.: Depressive symptoms in patients with obstructive sleep apnea: biological mechanistic pathways. Journal of Behavioral Medicine 40(6): 955-963, Dec 2017.

Gao, X., Azarbarzin, A., Keenan, B.T., Ostrowski, M., Pack, F.M., Staley, B., Maislin, G., Pack, A.I., Younes, M. and Kuna, S.T.: Heritability of heart rate response to arousals in twins. Sleep 40(6), Jun 2017 Notes: doi: 10.1093/sleep/zsx055. [Epub ahead of print]

Nikonova, E.V., Gilliland, J.D.A., Tanis, K.Q., Podtelezhnikov, A.A., Rigby, A.M., Galante, R.J., Finney, E.M., Stone, D.J., Renger, J.J., Pack, A.I. and Winrow, C.J.: Transcriptional profiling of cholinergic neurons from basal forebrain identifies changes in expression of genes between sleep and wake. Sleep 40(6), Jun 2017 Notes: doi: 10.1093/sleep/zsx059. [Epub ahead of print]

Morgan, A.P., Gatti, D.M., Najarian, M.L., Keane, T.M., Galante, R.J., Pack, A.I., Mott, R., Churchill, G.A., de Villena, F.P.: Structural variation shapes the landscape of recombination in mouse. Genetics 206(2): 603-619, Jun 2017.

Xu, L., Han, F., Keenan, B.T., Kneeland-Szanto, E., Yan, H., Dong, X., Chang, Y., Zhao, L., Zhang, X., Li, J., Pack, A.I. and Kuna, S.T.: Validation of the Nox-T3 portable monitor for diagnosis and obstructive sleep apnea in Chinese adults. Journal of Clinical Sleep Medicine 13(5): 675-683, May 2017.

Li, J., Chang, Y.P., Riegel, B., Keenan, B.T., Varrasse, M., Pack, A.I. and Gooneratne, N.S.: Intermediate, but not extended, afternoon naps may preserve cognition in Chinese older adults. Journals of Gerontology. Series A, Biological Sciences and Medical Sciences May 5 2017 Notes: doi: 10.1093/gerona/glx069. [Epub ahead of print]

Gerstner, J.R., Perron, I.J., Riedy, S.M., Yoshikawa, T., Kadotani, H., Owada, Y., Van Dongen, H.P.A., Galante, R.J., Dickinson, K., Yin, J.C.P., Pack, A.I. and Frank, M.G.: Normal sleep requires the astrocyte brain-type fatty acid binding protein FABP7. Science Advances 3(4): e1602663, Apr 2017.

Eyseinsdottir, B., Gislason, T., Pack, A.I., Benediktsdottir, B., Arnardottir, E.S., Kuna, S.T. and Bjornsdottir, E.: Insomnia complaints in lean obstructive sleep apnea patients negatively affect positive airway pressure treatment adherence. Journal of Sleep Research 26(2), Apr 2017.

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Last updated: 12/14/2017
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