Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.
Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).
Matura, L.A., Fargo, J., Fritz, J.S., Smith, K.A., Vaidya, A., Pinder, D., Archer-Chicko, C., Palevsky, H.I., Pack, A.I., Sommers, M.S. and Kawut, S.M.: Slow-paced respiration therapy to treat symptoms in pulmonary arterial hypertension. Heart Lung 46(1): 7-13, 2017.
Parthasarathy, S., Carskadon, M.A., Jean-Louis, G., Owens, J., Bramoweth, A., Combs, D., Hale, L., Harrison, E., Hart, C.N., Hasler, B.P., Honaker, S.M. Hertenstein, E., Kuna, S., Kushida, C., Levenson, J.C., Murray, C., Pack, A.I., Pillai, V., Pruiksma, K., Seixas, A., Strollo, P. Thosar, S.S., Williams, N. and Buysse, D.: Implementation of sleep and circadian science: recommendation from the Sleep Research Society and National Institutes of Health workshop. Sleep 39(12): 2061-2075, Dec 2016.
Modarres, M., Kuzma, N.N., Kretzmer, T., Pack, A.I., Lim, M.M.: EEG slow waves in traumatic brain injury: convergent findings in mouse and man. Neurobiology of Sleep and Circadian Rhythms Jul 2016 Notes: 2016 Jul 1;1. pii: S2451994416300025.
Lim, D.C., Brady, D.C., Soans, R., Kim, E.Y., Valverde, L., Keenan, B.T., Guo, X., Kim, W.Y., Park, M.J., Galante, R.J., Shackleford, J.A. and Pack, A.I.: Different cyclical intermittent hypoxia severities have different effects on hippocampal microvasculature. Journal of Applied Physiology (1985) 121(1): 78-88, Jul 2016.
Prasad, B., Usmani, S., Steffen, A.D., Van Dongen, H., Pack, F.M., Strakovsky, I., Staley, B., Dinges, D., Maislin, G., Pack, A.I. and Weaver, T.E.: Short-term variability in apnea-hypopnea index during extended home portable monitoring. Journal of Clinical Sleep Medicine 12(6): 855-863, Jun 2016.
Benotti, P., Wood, G.C., Argyropoulos, G., Pack, A., Keenan, B.T., Gao, X., Gerhard, G. and Still, C.: The impact of obstructive sleep apnea on nonalcoholic fatty liver disease in patients with severe obesity. Obesity 24(4): 871-877, Apr 2016.
Mullington, J.M., Abbott, .SM., Carroll, J.E., Dijk, D.J., Dinges, D.F., Gehrman, P.R., Ginsburg, G.S., Gozal, D., Haack, M., Lim, D.C., Macrea, M., Pack, A.I., Plante, D.T., Teske, J.A. and Zee, P.C.: Developing biomarker arrays predicting sleep and circadian-coupled risks to health. Sleep 39(4): 727-736, Apr 2016.
Magalang, U.J., Arnardottir, E.S., Chen, N.H., Cistulli, P.A., Gislason, T., Lim, D., Penzel, T., Schwab, R., Tufik, S. and Pack, A.I.: Agreement in the scoring of respiratory events among international sleep centers for home sleep testing. Journal of Clinical Sleep Medicine 12(1): 71-77, Jan 2016.
Bjornsdottir, E., Benediktsdottir, B., Pack, A.I., Arnardottir, E.S., Kuna, S.T., Gislason, T., Keenan, B.T., Maislin, G. and Sigurdsson, J.F.: The prevalence of depression among untreated obstructive sleep apnea patients using a standardized psychiatric interview. Journal of Clinical Sleep Medicine 12(1): 105-112, Jan 2016.
Zimmerman, J.E., Chan, M.T., Lenz, O.T., Keenan, B.T., Maislin, G. and Pack, A.I.: Glutamate is a wake active neurotransmitter in Drosophila melanogaster. Sleep 2016 Notes: Oct 28. pii: sp-00420-16. [Epub ahead of print]
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Last updated: 01/26/2017
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