faculty photo

Allan I. Pack

John Miclot Professor
Department: Medicine

Contact information
Center for Sleep and Circadian Neurobiology
Translational Research Laboratories
125 South 31st Street, Suite 2100
Philadelphia, PA 19104-3403
Office: 215-746-4806
Fax: 215-746-4814
Graduate Group Affiliations
University of Glasgow, Scotland, 1967.
Ph.D. (Mathematical models of lung function)
University of Glasgow, Scotland, 1976.
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Description of Research Expertise

Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.

Description of Clinical Expertise

Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).

Selected Publications

Lim, D., Brady, D., Po, P., Chuang, L-P., Marcondes, L., Kim, E., Keenan, B., Guo, X., Maislin, G., Galante, R. and Pack. A.I.: Simulating obstructive sleep apnea patients’ oxygenation characteristics into a mouse model of cyclical intermittent hypoxia. Journal of Applied Physiology 2014 (in press).

Arnardottir, E.S., Nikonova, E.V., Shockley, K.R., Podtelezhnikov, A.A., Anafi, R., Tanis, K.Q., Maislin, G., Stone, D.J., Renger, J.J., Winrow, C.J. and Pack, A.I.: Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation. Sleep 37(10): 1689-1698, Oct 2014.

Chi, L., Comyn F-L., Keenan, B.T., Cater, J., Maislin, G., Pack, A.I. and Schwab, R.J.: Heritability of craniofacial structures in normal subjects and patients with sleep apnea. Sleep 37(10): 1689-1698, Oct 2014.

Kim, A.M., Keenan, B.T., Jackson, N., Chan, E.L., Staley, B., Poptani, H., Torigian, D.A., Pack, A.I. and Schwab, R.J.: Tongue fat and its relationship to obstructive sleep apnea. Sleep 37(10): 1639-1648, Oct 2014.

Pellegrino, R., Kavakli, I.H., Goel, N., Cardinale, C.J., Dinges, D.F., Kuna, S.T., Maislin, G., Van Dongen, H.P.A., Tufik, S., Hogenesch, J.B., Hakonarson, H. and Pack, A.I.: A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans. Sleep 37(8): 1327-1336, Aug 2014.

Keenan, B.T., Maislin, G., Sunwoo, B.Y., Arnardottir, E.S., Jackson, N., Olafsson, I., Juliusson, S., Schwab, R.J., Gislason, T., Benedikstdottir, B. and Pack, A.I.: Obstructive sleep apnoea treatment and fasting lipids: A comparative effectiveness study. European Respiratory Journal 44(2): 405-414, Aug 2014.

Brennick, M.J., Delikatny, J., Pack, A.I., Pickup, S., Shinde, S., Zhu, J.X., Roscoe, I., Kim, D.Y., Buxbaum, L.U., Cater, J.R. and Schwab, R.J.: Tongue fat infiltration in obese versus lean Zucker rats. Sleep 37(6): 1095-1102, Jun 2014.

Brown, M.K., Chan, M.T., Zimmerman, J.E., Pack, A.I., Jackson, N.E. and Naidoo, N.: Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis. Neurobiology of Aging 35(6): 1431-1441, Jun 2014.

Sutherland, K., Schwab, R.J., Maislin, G., Lee, R.W.W., Benedikstdottir, B., Pack, A.I., Gislason, T., Juliusson, S. and Cistulli, P.A.: Facial phenotyping by quantitative photography reflects craniofacial morphology measured on MRI in Icelandic sleep apnea patients. Sleep 37(5): 959-968, May 2014.

Watson, N.F., Harden, K.P., Buchwald, D., Vitiello, M.V., Pack, A.I., Strachan, E. and Goldberg, J.: Sleep duration and depressive symptoms: a gene-environment interaction. Sleep 37(2): 351-358, Feb 2014.

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Last updated: 11/25/2014
The Trustees of the University of Pennsylvania