Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.
Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).
Sutherland, K., Schwab, R.J., Maislin, G., Lee, R.W.W., Benedikstdottir, B., Pack, A.I., Gislason, T., Juliusson, S. and Cistulli, P.A.: Facial phenotyping by quantitative photography reflects craniofacial morphology measured on MRI in Icelandic sleep apnea patients. Sleep 2014 (in press).
Lim, M., Elkind, J., Xiong, G., Galante, R., Zhu, J., Zhang, L., Lian, J., Rodin, J., Kuzma, N., Pack, A.I. and Cohen, A.: Dietary therapy mitigates persistent wake deficits caused by mild traumatic brain injury. Science Translational Medicine 2013 (in press).
Watson, N.F., Harden, K.P., Buchwald, D., Vitiello, M.V., Pack, A.I., Strachan, E. and Goldberg, J.: Sleep duration and depressive symptoms: a gene-environment interaction. Sleep 2013 (in press) Notes: Accepted 9/30/13.
Arnardottir, E.S., Janson, C., Bjornsdottir, E.M., Benediktsdottir, B., Juliusson, S., Kuna, S.T., Pack, A.I. and Gislason, T.: Nocturnal sweating—a common symptom of obstructive sleep apnoea: the Icelandic Sleep Apnoea Cohort. BMJ Open 3(5), May 2013 Notes: doi:pii: e002795. 10.1136/bmjopen-2013-002795. Print 2013.
Anafi, R.C., Pellegrino, R., Shockley, K.R., Romer, M., Tufik, S. and Pack, A.I.: Sleep is not just for the brain: transcriptional responses to sleep in peripheral tissues. BMC Genomics 14(1): 362, May 2013.
Izci Balserak, B., Jackson, N., Ratcliffe, S.A., Pack, A.I., and Pien, G.W.: Sleep-disordered breathing and daytime napping are associated with maternal hyperglycemia. Sleep and Breathing 17(3): 1093-1102, Jan 2013.
Bjornsdottir, E., Janson, C., Sigurdsson, J.F., Gehrman, P., Perlis, M., Juliusson, S., Arnardottir, E.S., Kuna, S.T., Pack, A.I., Gislason, T. Benediktsdottir, B.: Symptoms of insomnia among patients with obstructive sleep apnea before and after two years of positive airway pressure treatment. Sleep 36(12): 1901-1909, 2013.
Malhotra, A., Younes, M., Kuna, S.T., Benca, R., Kushida, C.A., Walsh, J., Hanlon, A., Staley, B., Pack, A.I. and Pien, G.W.: Performance of an automated polysomnography scoring system versus computer-assisted manual scoring. Sleep 36(4): 573-582, 2013.
Wimmer, M, Rising, J., Galante, R.J., Wyner, A., Pack, A.I. and Abel. T.: Aging in mice reduces the ability to sustain sleep/wake states. PLoS One 8(12): e81880, 2013.
McShane, B.B., Jensen, S.T., Pack, A.I. and Wyner, A.J.: Statistical learning with time series dependence: an application to scoring sleep in mice. Journal of the American Statistical Association 2013 Notes: DOI: 10.1080/01621459.2013.779838.
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Last updated: 12/17/2013
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