Dr. Pack is pursuing research on genetics/genomics of sleep and its disorders. His laboratory is conducting studies in Drosophila and mice and translating these findings to humans. A particular focus of Dr. Pack’s work is to evaluate the genetic determinants of sleep homeostasis. Studies are ongoing to evaluate molecular mechanisms of sleepiness and sleep promotion using both hypothesis-driven and discovery science. The latter involves analysis of the changes in the transcription with sleep/wake and sleep deprivation in identified neuronal populations. Techniques being used include behavioral/sleep studies in Drosophila and mice, RT-PCR, Western analysis of protein, expression profiling, laser microcapture dissection, RNA seq and immunohistochemistry. Dr. Pack is committed to research training and directs two training grants from the National Institutes of Health.
Dr. Pack's clinical expertise is in sleep disorders with a particular focus on diagnosis and management of obstructive sleep apnea. He is internationally recognized for his expertise in this area and has been listed in the Best Doctor's in the United States and in the Philadelphia region (Philadelphia Magazine).
Li, Q.Y., Berry, R.B., Goetting, M.G., Staley, B., Soto-Calderon, H., Tsai, S.C., Jasko, J.G., Pack, A.I. and Kuna, S.T.: Detection of upper airway status and respiratory events by a current generation positive airway pressure device. Sleep 38(4): 597-605, Apr 2015.
Pak, V.M., Keenan, B.T., Jackson, N., Grandner, M.A., Maislin, G., Teff, K., Schwab, R.J., Arnardottir, E.S., Juliusson, S., Benediktsdottir, B., Gislason, T. and Pack, A.I. : Adhesion molecule increases in sleep apnea: beneficial effect of positive airway pressure and moderation by obesity. International Journal of Obesity (London) 39(3): 472-479, 2015.
Azarbarzin, A., Ostrowski, M., Younes, M., Keenan, B.T., Pack, A.I., Staley, B. and Kuna, S.T.: Arousal responses during overnight polysomnography and their reproducibility in healthy young adults. Sleep 2015 Notes: Jan 12. pii: sp-00438-14. [Epub ahead of print]
Lim, D.C., Brady, D.C., Po, P., Chuang, L.P., Marcondes, L., Kim, E.Y., Keenan, B.T., Guo, X., Maislin, G., Galante, R.J. and Pack. A.I.: Simulating obstructive sleep apnea patients’ oxygenation characteristics into a mouse model of cyclical intermittent hypoxia. Journal of Applied Physiology 118(5): 544-557, 2015.
Arnardottir, E.S., Lim, D.C., Keenan, B.T., Maislin, G., Benediktsdottir, B., Juliusson, S., Pack, A.I. and Gislason, T.: Effects of obesity on the association between long-term sleep apnea treatment and changes in interleukin-6 levels: the Icelandic Sleep Apnea Cohort. Journal of Sleep Research 24(2): 148-159, 2015.
Iftikhar, I.H., Valentine, C.W., Bittencourt, L.R., Cohen, D.L., Fedson, A.C., Gíslason, T., Penzel, T., Phillips, C.L., Yu-sheng, L., Pack, A.I. and Magalang, U.J.: Effects of continuous positive airway pressure on blood pressure in patients with resistant hypertension and obstructive sleep apnea: a meta-analysis. Journal of Hypertension 32(12): 2341-2350, Dec 2014.
Ye, L., Pien, G.W., Ratcliffe, S.J., Rjornsdottir, E., Arnardottir, E.S., Pack, A.I., Benediktsdottir, B. and Gislason, T.: The different clinical faces of obstructive sleep apnoea: a cluster analysis. European Respiratory Journal 44(6): 1600-1607, Dec 2014.
Arnardottir, E.S., Nikonova, E.V., Shockley, K.R., Podtelezhnikov, A.A., Anafi, R., Tanis, K.Q., Maislin, G., Stone, D.J., Renger, J.J., Winrow, C.J. and Pack, A.I.: Blood-gene expression reveals reduced circadian rhythmicity in individuals resistant to sleep deprivation. Sleep 37(10): 1589-1600, Oct 2014.
Chi, L., Comyn F-L., Keenan, B.T., Cater, J., Maislin, G., Pack, A.I. and Schwab, R.J.: Heritability of craniofacial structures in normal subjects and patients with sleep apnea. Sleep 37(10): 1689-1698, Oct 2014.
Kim, A.M., Keenan, B.T., Jackson, N., Chan, E.L., Staley, B., Poptani, H., Torigian, D.A., Pack, A.I. and Schwab, R.J.: Tongue fat and its relationship to obstructive sleep apnea. Sleep 37(10): 1639-1648, Oct 2014.
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Last updated: 06/02/2015
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