Denys V. Volgin

Contact information

Department of Animal Biology, 209 E/VET,
3800 Spruce St
Philadelphia, PA 19104

Office: 215-898-6258

Email:
dvolgin@vet.upenn.edu

Publications

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Links
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Faculty webpage

Education
Ph.D. (Physiology)
Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, 1999.

Permanent link

Description of Research Expertise

My primary research interests are in the neural mechanisms of sleep abnormalities caused by prenatal exposure to alcohol, molecular and cellular mechanisms of the hypothalamic control of sleep and wakefulness, and their ontogenetic development.

My research experience also includes: central regulation of normal and disordered breathing (obstructive sleep apnea), postnatal development of the central pathways involved in the regulation of breathing, molecular and cellular mechanisms of oxygen deficiency (hypoxia), and molecular mechanisms of metabolic disorders (diabetes).

In our studies, we combine in vivo and in vitro experimental approaches and use various methods of molecular and cellular biology, neuroanatomy, and electrophysiology.

My key methodological expertise includes gene expression profiling and quantification at the single cell level.

Selected Publications

Volgin, DV: Perinatal alcohol exposure leads to prolonged upregulation of hypothalamic GABAA receptors and increases behavioral sensitivity to gaboxadol. Neuroscience Letters 439(2): 182-186, 2008 Notes: doi:10.1016/j.neulet.2008.05.011.

Thangavel, C, Dhir, RN, Volgin, DV, Shapiro, BH: Sex-dependent expression of CYP2C11 in spleen, thymus and bone marrow regulated by growth hormone. Biochemical Pharmacology 74(10): 1476-1484, NOV 15 2007.

Volgin, DV, Kubin, L: Regionally selective effects of GABA on hypothalamic GABA(A) receptor mRNA in vitro. Biochemical And Biophysical Research Communications 353(3): 726-732, FEB 16 2007.

Volgin, DV, Kubin, L: Chronic intermittent hypoxia alters hypothalamic transcription of genes involved in metabolic regulation. Autonomic Neuroscience-basic & Clinical 126: 93-99, JUN 30 2006.

Volgin, DV, Swan, J, Kubin, L: Single-cell RT-PCR gene expression profiling of acutely dissociated and immunocytochemically identified central neurons. Journal Of Neuroscience Methods 136(2): 229-236, JUL 30 2004.

Roy, A, Volgin, DV, Baby, SM, Mokashi, A, Kubin, L, Lahiri, S: Activation of HIF-1 alpha at mRNA by hypoxia and iron chelator in isolated rat carotid body. Neuroscience Letters 363(3): 229-232, JUN 17 2004.

Wang, LS, Whitbeck, JC, Lawrence, WC, Volgin, DV, Bello, LJ: Expression of the genomic form of the bovine viral diarrhea virus E2 ORF in a bovine herpesvirus-1 vector. Virus Genes 27(1): 83-91, AUG 2003.

Volgin, DV, Fay, R, Kubin, L: Postnatal development of serotonin 1B, 2A and 2C receptors in brainstem motoneurons. European Journal Of Neuroscience 17(6): 1179-1188, MAR 2003.

Volgin, DV, Mackiewicz, M, Kubin, L: alpha(1B) receptors are the main postsynaptic mediators of adrenergic excitation in brainstem motoneurons, a single-cell RT-PCR study. Journal Of Chemical Neuroanatomy 22(3): 157-166, SEP 2001.

Volgin, DV, Maiskii, VA, Vasilenko, DA, Seredenko, MM: NADPH-diaphorase-containing neurons in the medullary structures involved in generation of the respiratory activity in neonatal rats. Neurophysiology 32(2): 99-105, MAR-APR 2000.

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