Diet, the Gut Microbiome, and Host Metabolism
Dr. Wu is the Ferdinand G. Weisbrod Professor in Gastroenterology at the Perelman School of Medicine at the University of Pennsylvania where he is the Associate Chief for Research in the Division of Gastroenterology and is also the Associate Director of the Center for Molecular Studies in Digestive and Liver Disease. He is currently Director and Chair of the Scientific Advisory Board for the American Gastroenterological Association Center for Gut Microbiome Research and Education and is an elected member of both the American Society for Clinical Investigation and the American Association of Physicians. The research programs in the Wu laboratory focus on the mutualistic interactions between the gut microbiota and the host with a particular focus on metabolism. Growing evidence suggests that diet impacts upon both the structure and function of the gut microbiota that, in turn, influences the host in fundamental ways. Current areas of investigation include the effect of diet on the composition of the gut microbiota and its subsequence effect on host metabolism related to nitrogen balance as well as its impact on metabolic pathways in the intestinal epithelium, principally fatty acid oxidation. Through a UH3 roadmap initiate grant, he is helping to direct a project investigating the impact of diet on the composition of the gut microbiome and its relationship to therapeutic responses associated with the treatment of patients with Crohn’s disease using an elemental diet. Finally, Dr. Wu is leading a multidisciplinary group of investigators using phosphorescent nanoprobe technology to examine the dynamic oxygen equilibrium between the host and the gut microbiota at the intestinal mucosal interface.
Sue Ann Keilbaugh, PhD
Josephine Ni, MD
Ting-Chin David Shen, MD
Sarah Smith, PhD
Albenberg L, Esipova TV2, Judge CP1, Bittinger K3, Chen J4, Laughlin A3, Grunberg S3, Baldassano RN1, Lewis JD5, Li H4, Thom SR6, Bushman FD3, Vinogradov SA7, Wu GD8.: Correlation Between Intraluminal Oxygen Gradient and Radial Partitioning of Intestinal Microbiota. Gastroenterology. July 2014.
Albenberg LG, Wu GD: Diet and the intestinal microbiome: associations, functions, and implications for health and disease. Gastroenterology 2014.
Wu GD: Diet, the gut microbiome and the metabolome in IBD. Nestle Nutr Inst Workshop Ser 2014.
Owyang C, Wu GD: The gut microbiome in health and disease. Gastroenterology 2014.
Hecht GA, Blaser MJ, Gordon J, Kaplan LM, Knight R, Laine L, Peek R, Sanders ME, Sartor B, Wu GD, Yang VW: What is the value of a food and drug administration investigational new drug application for fecal microbiota transplantation to treat Clostridium difficile Infection? Clin Gastroenterol Hepatol 2014.
Bittinger K, Charlson ES, Loy E, Shirley DJ, Haas AR, Laughlin A, Yi Y, Wu GD, Lewis JD, Frank I, Cantu E, Diamond JM, Christie JD, Collman RG, Bushman FD: Improved characterization of medically relevant fungi in the human respiratory tract using next-generation sequencing. Genome Biol. 15: 487, 2014.
Wu GD, Compher C, Chen EZ, Smith SA, Shah RD, Bittinger K, Chehoud C, Albenberg LG, Nessel L, Gilroy E, Star J, Weljie AM, Flint HJ, Metz DC, Bennett MJ, Li H, Bushman FD, Lewis JD: Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production. Gut 2014.
Dollive S, Chen YY, Grunberg S, Bittinger K, Hoffmann C, Vandivier L, Cuff C, Lewis JD, Wu GD, Bushman FD.: Fungi of the murine gut: episodic variation and proliferation during antibiotic treatment. PLoS One. August 2013.
Minot S, Bryson A, Chehoud C, Wu GD, Lewis JD, Bushman FD.: Rapid evolution of the human gut virome. Proc Natl Acad Sci U S A. July 2013.
Han D, Walsh MC, Cejas PJ, Dang NN, Kim YF, Kim J, Charrier-Hisamuddin L, Chau L, Zhang Q, Bittinger K, Bushman FD, Turka LA, Shen H, Reizis B, Defranco AL, Wu GD, Choi Y.: Dendritic cell expression of the signaling molecule TRAF6 is critical for gut microbiota-dependent immune tolerance. Immunity. June 2013.
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Last updated: 12/05/2014
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