Kurt R Brunden, Ph.D.
Kurt R Brunden, Ph.D.
Research Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Contact information
Center for Neurodegenerative Disease Research
University of Pennsylvania
3600 Spruce St.
3rd Floor Maloney Bldg.
Philadelphia, PA 19104
University of Pennsylvania
3600 Spruce St.
3rd Floor Maloney Bldg.
Philadelphia, PA 19104
Office: 215-615-5262
Email:
kbrunden@upenn.edu
kbrunden@upenn.edu
Education:
B.S. (Biology/Health Chemistry)
Western Michigan University, 1980.
Ph.D. (Biochemistry)
Purdue University, 1985.
Permanent linkB.S. (Biology/Health Chemistry)
Western Michigan University, 1980.
Ph.D. (Biochemistry)
Purdue University, 1985.
Description of Research Expertise
Dr. Brunden oversees research programs directed towards the identification of therapeutic targets and treatments for Alzheimer's, Parkinson's and other neurodegenerative diseases.Selected Publications
Ballatore Carlo, Crowe Alex, Piscitelli Francesco, James Michael, Lou Kevin, Rossidivito Gabrielle, Yao Yuemang, Trojanowski John Q, Lee Virginia M-Y, Brunden Kurt R, Smith Amos B: Aminothienopyridazine inhibitors of tau aggregation: Evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties. Bioorganic & medicinal chemistry 20(14): 4451-61, Jul 2012.Cramer, PE, Cirrito JR, Wesson DW, Lee DCY, Karlo JC, Zinn AE, Casali BT, Restivo JL, Goebel WD, James MJ, Brunden KR, Wilson DA and Landreth GE : ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in mouse models of Alzheimer’s disease. Science In press, 2012.
Soper JH, Sugiyama S, Herbst-Robinson K, James MJ, Wang X, Trojanowski JQ, Smith AB III, Lee VM-Y, Ballatore C and Brunden KR: Brain-penetrant tetrahydronaphthalene thromboxan A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer’s disease. ACS Chem. Neurosci. 3: 928-940, 2012.
Trojanowski JQ, Arnold DE, Karlawish JH, Naylor M, Brunden KR and Lee VM-Y: A model for improving the treatment and care of Alzheimer’s disease patients through interdisciplinary research. Alzheimer’s & Dementia 8: 564-573, 2012.
Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AL, Xie SX, Ballatore C, Smith AB III, Lee VMY and Brunden KR : The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, cognitive deficits, neurotoxicity and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J. Neurosci. In press, 2012.
Ballatore Carlo, Soper James H, Piscitelli Francesco, James Michael, Huang Longchuan, Atasoylu Onur, Huryn Donna M, Trojanowski John Q, Lee Virginia M-Y, Brunden Kurt R, Smith Amos B: Cyclopentane-1,3-dione: A Novel Isostere for the Carboxylic Acid Functional Group. Application to the Design of Potent Thromboxane (A2) Receptor Antagonists. Journal of medicinal chemistry 54(19): 6969-83, Oct 2011.
Carroll Jenna C, Iba Michiyo, Bangasser Debra A, Valentino Rita J, James Michael J, Brunden Kurt R, Lee Virginia M-Y, Trojanowski John Q: Chronic Stress Exacerbates Tau Pathology, Neurodegeneration, and Cognitive Performance through a Corticotropin-Releasing Factor Receptor-Dependent Mechanism in a Transgenic Mouse Model of Tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience 31(40): 14436-49, Oct 2011.
Brunden Kurt R, Yao Yuemang, Potuzak Justin S, Ferrer Nuria Ibarz, Ballatore Carlo, James Michael J, Hogan Anne-Marie L, Trojanowski John Q, Smith Amos B, Lee Virginia M-Y: The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. Pharmacological research 63(4): 341-51, Apr 2011.
Anderson James T, Campbell Michael, Wang Jianmin, Brunden Kurt R, Harrington John J, Stricker-Krongrad Alain, Song Jianping, Doucette Chris, Murphy Steven, Bennani Youssef L: Investigation of 4-piperidinols as novel H3 antagonists. Bioorganic & medicinal chemistry letters 20(21): 6246-9, Nov 2010.
Brunden Kurt R, Zhang Bin, Carroll Jenna, Yao Yuemang, Potuzak Justin S, Hogan Anne-Marie L, Iba Michiyo, James Michael J, Xie Sharon X, Ballatore Carlo, Smith Amos B, Lee Virginia M-Y, Trojanowski John Q: Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. The Journal of neuroscience : the official journal of the Society for Neuroscience 30(41): 13861-6, Oct 2010.