Department of Genetics, University of Pennsylvania

Preprints

Gao C, Brown CD, Engelhardt BEE. A latent factor model with a mixture of sparse and dense factors to model gene expression data with confounding effects.
arXiv

Publications

McNerney ME, Brown CD, Peterson AL, Banerjee M, Larson RA, Anastasi J, Le Beau MM, White KP. The spectrum of somatic mutations in high-risk acute myeloid leukaemia with -7/del(7q). Br J Haematol. 2014 Jun 13. PMID: 24931631
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VanderWeele, D, Brown CD, Taxy J, Gillard M, Hatcher D, Westin T, Stadler W, White KP. Low grade prostate cancer diverges early from high grade and metastatic disease. Cancer Science. 2014 May 31. PMID: 24890684
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Georgi B, Craig D, Kember RL, Liu W, Lindquist I, Nasser S, Brown C, Egeland JA, Paul SM, Bućan M. Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate. PLoS Genet. 2014 Mar 13;10(3):e1004229. PMID: 24625924.
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Mangravite LM*, Engelhardt BE*, Medina MW, Smith JD, Brown CD, Chasman DI, Mecham BH, Howie B, Shim H, Naidoo D, Feng Q, Rieder MJ, Chen YDI, Rotter JI, Ridker PM, Hopewell JC, Parish S, Armitage J, Collins R, Wilke RA, Nickerson DA, Stephens M, Krauss RM. A statin-dependent QTL for GATM expression is associated with statin-induced myopathy. Nature. 2013 Oct 17;502(7471):377-80.
html | pdf | The Scientist | GEO

Brown CD, Mangravite LM, Engelhardt BE. Integrative modeling of eQTLs and cis-regulatory elements suggests mechanisms underlying cell type specificity of eQTLs. PLoS Genetics. 2013 9(8): e1003649.
html | pdf | arXiv | Haldane's Sieve

Brägelmann J, Dagogo-Jack I, El Dinali M, Stricker T, Brown CD, Zuo Z, Khattri A, Keck M, McNerney ME, Longnecker R, Bieging K, Kocherginsky M, Alexander K, Salgia R, Lingen MW, Vokes EE, White KP, Cohen EE, Seiwert TY. Oral cavity tumors in younger patients show a poor prognosis and do not contain viral RNA. Oral Oncology. 2013 Mar 9. PMID: 23490885
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Jiang Z, Xia F, Johnson K, Brown CD, Bartom E, Tuteja JH, Stevens R, Grossman R, Brumin M, White KP, Ghanim M. Comparison of the Genome Sequences of “Candidatus Portiera aleyrodidarum” Primary Endosymbionts of the Whitefly Bemisia tabaci B and Q Biotypes. Applied and Environmental Microbiology. 2013 Mar. PMID: 23315735
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McNerney ME, Brown CD, Wang X, Bartom ET, Karmakar S, Bandlamudi C, Yu S, Ko J, Sandall BP, Stricker T, Anastasi J, Grossman RL, Cunningham JM, Le Beau MM, White KP. CUX1 is a haploinsufficient tumor suppressor gene on chromosome 7 frequently inactivated in acute myeloid leukemia. Blood. 2013 Feb 7. PMID: 23212519
html | pdf | Blood editorial | Science Life | Cover Image

Gao W, Grossman R, Yu P, Brown CD, Slattery M, Ma L, White KP. Discovering Geometric Patterns in Genomic Data. ACM-BCB 2012.
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Hekman KE, Yu G*, Brown CD*, Zhu H, Du X, Gervin K, Undlien DE, Peterson A, Stevanin G, Clark HB, Pulst S, Bird T, White KP, Gomez CM. A Conserved eEF2 Coding Variant in SCA26 Leads to Loss of Translational Fidelity and Increased Susceptibility to Proteostatic Insult. Human Molecular Genetics. 2012 Sep 21. PMID:23001565.
html | pdf | SOM | F1000

Doré LC, Chlon TM, Brown CD, White KP, Crispino JD. Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis. Blood. 2012 Apr 19;119(16):3724-33. PMID:22383799.
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Yong Tao, Jue Ruan, Shiou-Hwei Yeh, Xuemei Lu, Yu Wang, Weiwei Zhai, Jun Cai, Shaoping Ling, Qiang Gong, Zecheng Chong, Zhengzhong Qu, Qianqian Li, Jiang Liu, Jin Yang, Caihong Zheng, Changqing Zeng, Hurng-Yi Wang, Jing Zhang, Sheng-Han Wang, Lingtong Hao, Lili Dong, Wenjie Li, Min Sun, Wei Zou, Caixia Yu, Chaohua Li, Guojing Liu, Lan Jiang, Jin Xu, Huanwei Huang, Chunyan Li, Shuangli Mi, Bing Zhang, Baoxian Chen, Wenming Zhao, Songnian Hu, Shi-Mei Zhuang, Yang Shen, Suhua Shi, Brown CD, White KP, Ding-Shinn Chen, Pei-Jer Chen, Chung-I Wu. Rapid growth of a hepatocellular carcinoma and the driving mutations revealed by cell-population genetic analysis of whole-genome data. Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12042-7. PMID: 21730188.
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Innocenti F*, Cooper GM*, Stanaway IB, Gamazon ER, Smith JD, Mirkov S, Ramirez J, Liu W, Lin YS, Maloney C, Force Aldred S,Trinklein ND, Schuetz E, Nickerson DA, Thummel KE, Rieder MJ, Rettie AE, Ratain MJ, Cox NJ, Brown CD. Identification, replication, and functional fine-mapping of expression quantitative trait loci in primary human liver tissue. PLoS Genetics 2011 7(5): e1002078. PMID: 21637794
html | pdf | Merck GEO | UC GEO | UW GEO | eQTL Browser

Nègre N*, Brown CD*, Ma L*, Bristow CA*, Miller SW*, Wagner U*, Kheradpour P, Eaton ML, Loriaux P, Sealfon R, Li Z, Ishii H, Spokony RF, Chen J, Hwang L, Cheng C, Auburn RP, Davis MB, Domanus M, Shah PK, Morrison CA, Zieba J, Suchy S, Senderowicz L, Victorsen A, Bild NA, Grundstad AJ, Hanley D, MacAlpine DM, Mannervik M, Venken K, Bellen H, White R, Gerstein M, Russell S, Grossman RL, Ren B, Posakony JW, Kellis M, White KP. A cis-regulatory map of the Drosophila genome. Nature 2011 Mar 24;471(7339):527-31. PMID: 21430782
html | pdf | SOM | GEO | Data on modMine | News and Views | F1000

The modENCODE Consortium, et al. Identification of functional elements and regulatory circuits in Drosophila by large-scale data integration. Science 2010 Dec 24;330(6012):1787-97. PMID: 21177974
html | pdf | SOM | Web Companion | Science Perspective | Science Editorial | NRG Highlight

Nègre N*, Brown CD*, Shah P, Kheradpour P, Morrison CA, Henikoff JG, Feng X, Ahmad K, Russell S, White RAH, Stein L, Henikoff S, Kellis M, White KP. A comprehensive map of insulator elements for the Drosophila genome. PLoS Genetics 2010 Jan 15; 6(1):e1000814. PMID: 20084099
html | pdf | Insulator beds | GEO | modENCODE data

Celniker SE, Dillon LAL, Gerstein MB, Gunsalus KC, Henikoff S, Karpen GH, Kellis M, Lai EC, Lieb JD, MacAlpine DM, Micklem G, Piano F, Snyder M, Stein L, White KP, Waterston RH, modENCODE Consortium. Unlocking the Secrets of the Genome. Nature. 2009 Jun 18;459(7249):927-30. PMID: 19536255
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Liu J, Ghanim M, Xue L, Brown CD, Iossifov I, Angeletti C, Hua S, Nègre N, Ludwig M, Stricker T, Al-Ahmadie HA, Tretiakova M, Camp RL, Perera-Alberto M, Rimm DL, Xu T, Rzhetsky A, White KP. Analysis of Drosophila Segmentation Network Identifies a JNK Pathway Factor Overexpressed in Kidney Cancer. Science 2009 Feb 27;323(5918):1218-22. PMID: 19164706.
html | pdf | SOM | GEO | NRG Highlight | F1000

Cooper GM and Brown CD. Qualifying the relationship between sequence conservation and molecular function. Genome Research 2008 Feb, 18:201-205. PMID: 18245453
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Brown CD. Ph.D. Thesis, 2007, Stanford University
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Brown CD, Johnson DS, Sidow A. Functional architecture and evolution of transcriptional elements that drive gene coexpression. Science 2007 Sept 14, 317:1557-1560. PMID: 17872446
html | pdf | SOM | More Data | NRG Highlight

Johnson DS, Davidson B, Brown CD, Smith WC, Sidow A. Noncoding regulatory sequences of Ciona exhibit strong correspondence between evolutionary constraint and functional importance. Genome Research 2004 Dec;14(12):2448-56. PMID: 15545496
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*Denotes equal contributions