Beatty Lab
Recent Research Publications
- Beatty, G.L., Chiorean, E.G., Fishman, M.P., Saboury, B., Teitelbaum, U.R., Sun, W., Huhn, R.D., Li, D., Sharp, L.L., Torigian, D.A., O’Dwyer, P.J., and R.H Vonderheide. 2011. CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans. Science. 331:1612-16. PMCID: PMC3406187.
- Rhim, A.D, Mirek, E.T., Aiello, N.M., Maitra, A., Bailey, J.M., McCallister, F., Reichert, M., Beatty, G.L., Rustgi, A.K.., Vonderheide, R.H., Leach, S.D., and B.Z. Stanger. 2012. EMT and dissemination precede pancreatic tumor formation. Cell. 148:349-61. PMCID: PMC3266542.
- Bayne, L.J., Beatty, G.L., Jhala, N., Clark, C.E., Rhim, A.D., Stanger, B.Z., and R.H. Vonderheide. 2012. Tumor-derived granulocyte-macrophage colony stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell. 21:822-35. PMCID: PMC3575028.
- Maus, M.V., Haas, A.R., Beatty, G.L., Albelda, S.M., Levine, B.L., Liu, X., Zhao, Y., Kalos, M., and C.H. June. 2013. T cells expressing chimeric antigen receptors can cause anaphylaxis in humans. Cancer Immunology Research. 1:26-31. PMCID: PMC3888798.
- Beatty, G.L., Torigian, D.A., Chiorean, E.G., Saboury, B., Brothers, A., Alavi, A., Troxel, A.B., Sun, W., Teitelbaum, U.R., Vonderheide, R.H., and P.J. O'Dwyer. 2013. A phase I study of an agonist CD40 monoclonal antibody (CP-870,893) in combination with gemcitabine in patients with advanced pancreatic ductal adenocarcinoma. Clin Cancer Res. 19:6286-95. PMCID: PMC3834036.
- Beatty, G.L., Haas, A.R., Maus, M.V., Torigian, D.A., Soulen, M.C., Plesa, G., Chew, A., Zhao, Y., Levine, B.L., Albelda, S.M., Kalos, M., and C.H. June. 2014. Mesothelin-specific chimeric antigen receptor mRNA-engineered T cells induce anti-tumor activity in solid malignancies. Cancer Immunology Research. 2:112-120. PMCID: PMC3932715.
- Beatty, G.L., Winograd, R., Evans, R.A., Long, K.B., Luque, S.L., Lee, J.W., Gladney, W.L., Guirnalda, P.D., and R.H. Vonderheide. 2015. Productive T cell immunity against pancreatic carcinoma in mice is regulated by Ly6Clow F4/80+ extratumoral macrophages. Gastroenterology. 149:201 PMCID: PMC4478138.
- Long, K.B., Gladney, W.L., Tooker, G.M., Graham, K., Fraietta, J.A., and G.L. Beatty. 2016. IFN-gamma and CCL2 cooperate to redirect tumor-infiltrating monocytes to degrade fibrosis and enhance chemotherapy efficacy in pancreatic carcinoma. Cancer Discovery. 6:400-413. PMCID: PMC4843521.
- Zhang, Y., Velez-Delgado, A., Mathew, E., Li, D., Mendez, F.M., Flannagan, K., Rhim, A.D., Simeone, D.M., Beatty G.L. and M. Pasca di Magliano. 2017. Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer. Gut. 66: 124-136. PMID: 27402485.
- Kalbasi, A., Komar, C.A., Tooker, G.M., Liu, M., Lee, J.W., Gladney, W.L., and G.L. Beatty. 2017. Tumor-derived CCL2 mediates resistance to radiotherapy in pancreatic ductal adenocarcinoma. Clin Cancer Res. 23:137-148. PMCID: PMC5195913.
- Beatty, G.L., O’Dwyer, P.J., Clark, J., Shi, J.G., Bowman, K.J., Scherle, P.A., Newton, R.C., Schaub, R., Maleski, J., Leopold, L., and T.F. Gajewski. 2017. First-in-human phase 1 study of the oral inhibitor of indoleamine 2,3-dioxygenase-1 epacadostat (INCB024360) in patients with advanced solid malignancies. Clin Cancer Res. In press.
- Long, K.B., Tooker, G., Tooker, E., Luque, S.L., Lee, J.W., Pan, X., and G.L. Beatty. 2017 IL-6 receptor blockade enhances chemotherapy efficacy in pancreatic ductal adenocarcinoma. Mol Cancer Ther. In press.