About Us

We understand that no mood or anxiety illness is the same.

Our mission at the Center for Neuromodulation in Depression and Stress aims to leverage cutting edge neuroscience for personalized treatment. Since its founding in 2013, CNDS has consistently augmented and capitalized on the efforts of the outstanding neuroscience community at the University of Pennsylvania. We have been able to spur innovative research on the mechanisms underlying individual treatment responses across mood disorders, including depression, anxiety, bipolar disorder, and post-traumatic stress disorder (PTSD). Examined broadly, we determine how various treatments produce changes in brain activity and connectivity in order to improve treatment outcomes.

 

Administration of transcranial magnetic stimulation (TMS), a non-invasive procedure that uses magnetic fields to selectively stimulate targeted brain regions.
 
Our studies have examined:
  • How individualized stimulation frequencies in transcranial magnetic stimulation (TMS) affects depressive symptoms in major depression and bipolar disorder
  • How transdiagnostic dimensions of psychopathology (e.g. rumination, negative affect, anxious arousal) in anxious misery disorders (depression, anxiety, PTSD) relate to brain structure, resting state fMRI connectivity, task-evoked fMRI brain activity, and neuropsychological performance
  • How computer-augmented cognitive behavioral therapy (CBT) produces changes in resting state fMRI connectivity and task-evoked fMRI brain activity that relate to treatment response
  • How fMRI feedback conducted in real-time (cloud based/AI feedback) in the scanner can reduce negative attentional biases in depression
  • How to optimize neuromodulation using psychopathology and neuroimaging 

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