FMIG Functional and Metabolic Imaging Group

  • Ventilation and Oxygen Tension Imaging

    Ventilation and Oxygen Tension Imaging

    Central coronal hyperpolarized 3He spin density and alveolar partial pressure of oxygen (pAO2) maps in representative subjects (2 Healthy Nonsmokers, 1 Asymptomatic Smoker and 3 COPDs). The histogram shows the whole-lung distribution and the mean and standard deviation was extracted from a Gaussian fit to the histograms. The PFT metrics, age and smoking history is listed for comparison.... Read More

  • Specific Ventilation Imaging

    Specific Ventilation Imaging

    Signal buildup during repeated hyperpolarized 3He breaths in a healthy 26-year-old nonsmoker (top), an asymptomatic 57-year-old smoker (35 pack-years, middle) and a 64-year-old COPD subject (GOLD stage 2, bottom) show the progression of nonuniform ventilation and the apparent resolution of some (but not all) defects during an extended breathing sequence.... Read More

  • Multi-breath vs Single-breath Maneuver

    Multi-breath vs Single-breath Maneuver

    A comparison of hyperpolarized 3He spin density in a multi-breath regimen. The first (top) and seventh (bottom) image in all slices of a 69-year-old stage 2 COPD subject. The initial signal intensity is highly inhomogeneous and is characterized by a small volume of hyperventilated lung due to partial or complete obstruction in other regions. Although gas is eventually exchanged with much of the lung, the abnormal tissue mechanics in these focal areas may contribute to subsequent emphysematous remodeling.... Read More

  • Multi-breath Imaging Sequence

    Multi-breath Imaging Sequence

    A developed scheme for imaging the regional fractional ventilation (FV), partial alveolar pressure of oxygen (pAO2), lung microstructure (ADC) and oxygen uptake (R) in human lungs using a single protocol with a multi-breath regimen.... Read More

  • Human Passive Gas Delivery Device

    Human Passive Gas Delivery Device

    A prototype device (left) delivers 3He/N2/O2 at a prescribed ratio and volume using pre-mixed containers and measured flow. The subject breathes voluntarily through a mouthpiece (right, inset); each inhalation is measured using two pneumotachometers stopped automatically using pneumatically controlled valves at the target volume. The subject voluntarily maintains lung volume at for the necessary 0.5-10s at end inhale using an audible signal, and imaging is synchronized to the breathing cycle automatically.... Read More

  • Dynamic Nuclear Polarization

    Dynamic Nuclear Polarization

    Figure on the left shows a schematic of solid 129Xe sample after annealing for several hours. The spheres represent the segregated pure xenon clusters surrounded by glassy matrix comprising of xenon, glassing agent and radical. During DNP, polarization is transferred from the glass matrix to the surface of the clusters, which propagates via spin diffusion into the cluster.... Read More

  • Real-Time Metabolic Profiling

    Real-Time Metabolic Profiling

    The figure shows a waterfall plot depicting the kinetic profile of isolated perfused lungs after injection with hyperpolarized [1-13C] pyruvate. Perturbation of the lung environment results in significant differences of kinetic profile of the perfused lungs.

About

The goal of the Functional and Metabolic Imaging Group (FMIG) is the development and application of novel hyperpolarized MRI techniques capable of diagnosing a variety of pulmonary and metabolic disorders. Specifically, our research activities at FMIG is divided into four general branches:

  1. The development of novel imaging techniques for the quantitative assessment of pulmonary structure and function through use of hyperpoliarzied gas (3He and 129Xe).
  2. Development of real-time metabolic imaging techniques to investigate the use of hyperpolarized 13C-labeled metabolites (e.g. [1-13C]pyruvate) for imaging lung perfusion and pulmonary pH, as well as detecting aberrant metabolism, which is a key pathological indication for a number of disease states, including cancer in other organs including liver, brain and heart.
  3. Study of the Dynamic Nuclear polarization (DNP) and Optical pumping technologies and polarization dominant relaxation mechanisms with the aim of increasing polarization levels as well extension of longitudinal relaxation.
  4. Implementation of rapid imaging pulse sequences and their applications in hyperpolarized MRI.

News & Announcements

  • 10 Dec, 2012

    Call for Abstracts for The 2013 International Functional Lung Imaging Workshop. Click Here for more infomation

  • 15 May, 2012

    Call for Abstracts for the Third Metabolic Imaging Workshop.

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