Current Publications

2010 Publications

2009 Publications

2010 Publications

T-antigen transformation of pituitary cells captures three novel cell lines in the Pit-1 lineage. Sizova D, Ho Y, Cooke NE, Liebhaber, SA. Molecular Endocrinology November 1, 2010. vol. 24 no. 11, 2232-2240.

Reversal of preexisting hyperglycemia in diabetic mice by acute deletion of the Men1 gene. Yang Yuqing, Gurung Buddha, Wu Ting, Wang Haoren, Stoffers Doris A, Hua Xianxin. Proceedings of the National Academy of Sciences of the United States of America. Published online before print November 8, 2010.

O2 regulates stem cells through Wnt/β-catenin signalling. Mazumdar Jolly, O'Brien W Timothy, Johnson Randall S, LaManna Joseph C, Chavez Juan C, Klein Peter S, Simon M Celeste. Nature Cell Biology 12(10): 1007-13, Oct 2010.

Experimental colitis triggers the release of substance P and calcitonin gene-related peptide in the urinary bladder via TRPV1 signaling pathways. Pan XQ, Gonzalez JA, Chang S, Chacko S, Wein AJ, Malykhina AP. Exp Neurol. 2010 Oct; 225(2):262-73.

Detrusor overactivity is associated with the down-regulation of large conductance calcium- and voltage-activated potassium channel protein. Chang S, Gomes CM, Hypolite JA, Marx J, Alanzi J, Zderic SA, Malkowicz B, Wein AJ, Chacko S. Am J Physiol Renal Physiol. 298.1416-1423, 2010.

Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Aggarwal Priya, Vaites Laura Pontano, Kim Jong Kyong, Mellert Hestia, Gurung Buddha, Nakagawa Hiroshi, Herlyn Meenhard, Hua Xianxin, Rustgi Anil K, McMahon Steven B, Diehl J Alan. Cancer Cell 18(4): 329-40, Oct 2010.

Large Copy-Number Variations Are Enriched in Cases With Moderate to Extreme Obesity. Wang K, Li WD, Glessner JT, Grant SF, Hakonarson H, Price AR. Diabetes. 2010 Oct; 59(10):2690-4.

A Genome-wide Study Reveals Copy Number Variants Exclusive
to Childhood Obesity Cases.
Glessner, JT, Bradfield, JP, Wang K,

Takahashi, N, Zhang, H, Sleiman, PM, Mentch, FD, Kim CE, Cuiping H, Thomas KA, Garris ML, Deliard S, Frackelton EC, Otieno, FG, Zhao J, Chiavacci RM, Li M, Buxbaum JD, Berkowitz, RI, Hakonarson H, Grant SF. The American Journal of Human Genetics (2010), DOI:10.1016/j.ajhg.2010.09.014

ß-catenin Primes Organizer Gene Expression By Recruiting a Histone H3 Arginine 8 Methyltransferase, Prmt2. Blythe SA, Cha SW, Tadjuidje E, Heasman J, and PS Klein. Developmental Cell. 2010 Aug 17;19(2):220-31. (highlighted by commentaries in Developmental Cell and Nature Reviews Genetics).

AMPK supports growthin Drosophila by regulating muscle activity and nutrient uptake in the gut. Bland ML, Lee RJ, Magallanes JM, Foskett JK, Birnbaum MJ. Dev Biol. 2010 Aug 1;344(1):293-303. 

Pseudogene-mediated posttranscriptional silencing of HMGA1 can result in insulin resistance and type 2 diabetes. Chiefari E, Iiritano S, Paonessa F, Le Pera I, Arcidiacono B, Filocamo M, Foti D, Liebhaber SA, Brunetti A. Nature Communications 1:40, 27 July 2010.

Hospitalization costs associated with Warfarin-related bleeding events among older community-dwelling adults. Kim M, Metlay J, Cohen A, Feldman H, Hennessy S, Kimmel S, Strom B, Doshi JA.  Pharmacoepidemiology and Drug Safety. 2010 Jul;19(7):731-6.

Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria. Cárdenas C, Miller RA, Smith I, Bui T, Molgó J, Müller M, Vais H, Cheung KH, Yang J, Parker I, Thompson CB, Birnbaum MJ, Hallows KR, Foskett JK. Cell. 2010 Jul 23;142(2):270-83. 

Regulation of cyclin B2 expression and cell cycle G2/m transition by menin. Wu Ting, Zhang Xiuli, Huang Xiaohua, Yang Yuqing, Hua Xianxin. The Journal of Biological Chemistry 285(24): 18291-300, Jun 2010.

MLL-AF9-Induced Leukemogenesis Requires Coexpression of the Wild-Type Mll Allele. Thiel AT, Blessington P, Zou T, Feather D, Wu X, Yan J, Zhang H, Liu Z, Ernst P, Koretzky GA, Hua X. Cancer Cell 17(2): 148-159, Feb 2010.

Selective ignorability assumptions in causal inference. Joffe MM, Yang P, Feldman HI. International Journal of Biostatistics, 6(2), Article 11, 2010.

Prevalence of Ocular Fundus Pathology in Subjects with Chronic Kidney Disease: The Chronic Renal Insufficiency Cohort (CRIC) Study.Grunwald JE, Alexander J, Maguire M, Whittock R, Parker C, McWilliams K, Lo JC, Townsend R, Gadegbeku CA, Lash JP, Fink JC, Rahman M, Feldman H, Kusek J, Ojo A, The CRIC Study Group.  Clinical Journal of the American Society of Nephrology. May 2010 vol. 5 no. 5 867-873.

An energetic tale of AMPK-independent effects of metformin. Miller RA, Birnbaum MJ. J Clin Invest. 2010 Jul 1;120(7):2267-70.

Pioglitazone for the treatment of type 2 diabetes in patients inadequately controlled on insulin. Schwartz S. Dovepress Journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 8 Jul 2010.

Type 2 diabetes mellitus and the cardiometabolic syndrome: impact of incretin-based therapies. Schwartz S, Kohl BA. Dovepress Journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 8 Jul 2010.

Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA
dehydrogenase deficiency involves activation of glutamate dehydrogenase.
Li C, Chen P, Palladino A, Narayan S, Russell LK, Sayed S, Xiong G, Chen J, Stokes D, Butt YM, Jones PM, Collins HW, Cohen NA, Cohen AS, Nissim I, Smith TJ, Strauss AW, Matschinsky FM, Bennett MJ, Stanley, CA. The Journal of Biological Chemistry. 2010 Jul 29. [Epub ahead of print] PMID: 20670938

Disease-associated loci are significantly over-represented among genes bound by transcription factor 7-like 2 (TCF7L2) in vivo. Zhao J, Schug J, Li M, Kaestner KH, Grant SF. Diabetologia. 2010 Jul 17. [Epub ahead of print] PMID: 20640398

AKT and TOR signaling set the pace of the circadian pacemaker.

Zheng X, Sehgal A. Curr Biol. 2010 Jul 13;20(13):1 203-8. Epub 2010 Jun 17. PMID: 20619819.

Catecholamines, adiponectin, and insulin resistance as measured by HOMA in children with obstructive sleep apnea. Kelly A, Dougherty S, Cucchiara A, Marcus CL, Brooks LJ. Sleep. 2010 Jun 22.

Cdx2 regulates endo-lysosomal function and epithelial cell polarity.

Gao N, Kaestner KH. Genes Dev. 2010 Jun 15;24(12):1295-305. PMID: 20551175.

Variability of creatinine measurements in clinical laboratories: results from the CRIC Study. Joffe M, Hsu C, Feldman HI, Weir M, Landis JR, Hamm LL on behalf of the Chronic Renal Insufficiency Cohort (CRIC) Study Group.   American Journal of Nephrology Vol. 31, No. 5, 2010; 426-434 2010.

Relationship of Microparticles to Progenitor Cells as a Measure of Vascular Health in a Diabetic Population. Curtis AM, Zhang L, Medenilla E, Gui M, Wilkinson PF, Hu E, Giri J, Doraiswamy V, Gunda S, Burgert ME, Moore JS, Edelberg JM, Mohler ER, Cytometry B Clin Cytom. 2010 Jun 11.

Endogenous leptin signaling in the caudal nucleus tractus solitarius and area postrema is required for energy balance regulation.Hayes MR, Skibicka KP, Leichner TM, Guarnieri DJ, DiLeone RJ, Bence KK, Grill HJ.Cell Metab. 2010 Jan;11(1):77-83.

Pseudogene-mediated posttranscriptional silencing of HMGA1 can result in insulin resistance and type 2 diabetes. Chiefari E, Iiritano S, Paonessa F, Le Pera I, Arcidiacono B, Filocamo M, Foti D, Liebhaber SA, Brunetti A. Nature Communications. 25 Jun 2010. DOI: 10.1038/ncomms1040


Glucagon Deficiency Reduces Hepatic Glucose Production and Improves Glucose Tolerance In Adult Mice. Hancock, A.S., Du A, Liu J, Mayumi Miller M, May C.L. Mol. Endocrinol. 2010 24:1605-1614.

Ovarian hormone-induced reorganization of oxytocin-labeled dendrites and synapses lateral to the hypothalamic ventromedial nucleus in female rats. Griffin, G.D., Ferri-Kolwicz, S.L., Reyes, B.S., Van Bockstaele, E. J., and Flanagan-Cato, L.M. Journal of Comparative Neurology. June 2010.

Detrusor overactivity is associated with the down-regulation of large conductance calcium- and voltage-activated potassium channel protein. Chang S, Gomes CM, Hypolite JA, Marx J, Alanzi J, Zderic SA, Malkowicz B, Wein AJ, Chacko S. Am J Physiol Renal Physiol. 298(6):F1416-23. PMID: 20392804

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Freathy RM, Mook-Kanamori DO, Sovio U, Prokopenko I, Timpson NJ, Berry DJ, Warrington NM, Widen E, Hottenga JJ, Kaakinen M, Lange LA, Bradfield JP, Kerkhof M, Marsh JA, Mägi R, Chen CM, Lyon HN, Kirin M, Adair LS, Aulchenko YS, Bennett AJ, Borja JB, Bouatia-Naji N, Charoen P, Coin LJ, Cousminer DL, de Geus EJ, Deloukas P, Elliott P, Evans DM, Froguel P; Genetic Investigation of ANthropometric Traits (GIANT) Consortium, Glaser B, Groves CJ, Hartikainen AL, Hassanali N, Hirschhorn JN, Hofman A, Holly JM, Hyppönen E, Kanoni S, Knight BA, Laitinen J, Lindgren CM; Meta-Analyses of Glucose and Insulin-related traits Consortium, McArdle WL, O'Reilly PF, Pennell CE, Postma DS, Pouta A, Ramasamy A, Rayner NW, Ring SM, Rivadeneira F, Shields BM, Strachan DP, Surakka I, Taanila A, Tiesler C, Uitterlinden AG, van Duijn CM; Wellcome Trust Case Control Consortium, Wijga AH, Willemsen G, Zhang H, Zhao J, Wilson JF, Steegers EA, Hattersley AT, Eriksson JG, Peltonen L, Mohlke KL, Grant SF, Hakonarson H, Koppelman GH, Dedoussis GV, Heinrich J, Gillman MW, Palmer LJ, Frayling TM, Boomsma DI, Davey Smith G, Power C, Jaddoe VW, Jarvelin MR; Early Growth Genetics (EGG) Consortium, McCarthy MI. Nat Genet. 2010 May;42(5):430-5. Epub 2010 Apr 6. PMID: 20372150

Social Capitol and Glucose Control. Long JA, Field S, Armstrong K, Chang VW, Metlay JP. Journal of Community Health. 2010 Feb 9. [Epub ahead of print].

Promoters and barriers to fruit, vegetable, and fast-food consumption among urban, low-income African Americans--a qualitative approach.

Lucan SC, Barg FK, Long JA. Am J Public Health. 2010 Apr;100(4):631-5. Epub 2010 Feb 18. PMID: 20167885

Quality of care among obese patients. Chang VW, Asch DA, Werner RM. JAMA. 2010 Apr 7;303(13):1274-81. PMID: 20371786

Beta-Cell secretory capacity and demand in recipients of islet, pancreas, and kidney transplants. Rickels MR, Mueller R, Teff KL, Naji A. J Clin Endocrinol Metab. 2010 Mar;95(3):1238-46. Epub 2010 Jan 22.PMID: 20097708

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice. Banno R, Zimmer D, De Jonghe BC, Atienza M, Rak K, Yang W, Bence KK. J Clin Invest. 2010 Mar 1;120(3):720-34. Epub 2010 Feb 15. PMID: 20160350.

Cell-Specific Determinants of Peroxisome Proliferator-Activated Receptor {gamma} Function in Adipocytes and Macrophages. Lefterova MI, Steger DJ, Zhuo D, Qatanani M, Mullican SE, Tuteja G, Manduchi E, Grant GR, Lazar MA. Mol Cell Biol. 2010 Feb 22. [Epub ahead of print] PMID: 20176806

2008 Publications

Targeting the pathophysiology of type 2 diabetes: rationale for combination therapy with pioglitazone and exenatide. Schwartz, S. Current Medical Research and Opinion, 2008, 24:3009-3022.

Synergy in diabetes treatment. Schwartz, S. Review in Endocrinology, November 2008.

Loss of confidence in diabetes management. Salber PR, Bestermann W, Schwartz S, Marchetti A. Manag Care. 2008 Oct;17(10):38-46.

Food Restriction Alters Neuronal Morphology in the Hypothalamic Ventromedial Nucleus of Male Rats. Flanagan-Cato, L.M., Fluharty, S.J., Weinreb, E.B., and LaBelle, D.R. Endocrinology. 2008; 149: 93-99.

Estradiol and progesterone differentially regulate the dendritic arbor of neurons in the hypothalamic ventromedial nucleus of the female rat (Rattus norvegicus). Griffin, G.D. and Flanagan-Cato, L.M. Journal of Comparative Neurology. 2008; 510: 631-640.

Reverse engineering the lordosis behavior circuit. Pfaff, D.W., L.-M. Kow, M. Loose, L.M. Flanagan-Cato. Hormones and Behavior. 2008; 55: 347–354.