Current Publications

2010 Publications

2009 Publications

2011-2012 Publications

Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.  Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA. Science. 2012 Mar 30;335 (6076):1638-43.

Foxa1 and Foxa2 Are Essential for Sexual Dimorphism in Liver Cancer. Zhaoyu Li1, Geetu Tuteja, Jonathan Schug, Klaus H. Kaestner. Cell. Volume 148, Issues 1–2, 20 January 2012, Pages 72–83.

Insulin regulates liver metabolism in vivo in the absence of hepatic Akt and Foxo1. Mingjian Lu, Min Wan, Karla F Leavens, Qingwei Chu, Bobby R Monks, Sully Fernandez, Rexford S Ahima, Kohjiro Ueki, C Ronald Kahn & Morris J Birnbaum. Nature Medicine February 2012.

BMD-Associated Variation at the Osterix Locus Is Correlated With Childhood Obesity in Females. Zhao J, Bradfield JP, Li M, Zhang H, Mentch FD, Wang K, Sleiman PM, Kim CE, Glessner JT, Frackelton EC, Chiavacci RM, Berkowitz RI, Zemel BS, Hakonarson H, Grant SF.Obesity (Silver Spring). 2011 Jan 6. [Epub ahead of print]

No Kiss1ng by leptin during puberty? Ahima RS. J Clin Invest. 2011;121(1):34-6. PMCID: 3007174.

Inflammatory induction of human resistin causes insulin resistance in endotoxemic mice. Park HK, Qatanani M, Briggs ER, Ahima RS, Lazar MA. Diabetes. 2011;60(3):775-83. PMCID: 3046838.

Targeting the Activin Type IIB Receptor to Improve Muscle Mass and Function in the mdx Mouse Model of Duchenne Muscular Dystrophy. Pistilli EE, Bogdanovich S, Goncalves MD, Ahima RS, Lachey J, Seehra J, Khurana T. Am J Pathol. 2011;178(3):1287-97.

TNF-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome. Stanley TL, Zanni MV, Johnsen S, Rasheed S, Makimura H, Lee H, Khor VK, Ahima RS, Grinspoon SK. J Clin Endocrinol Metab. 2011;96(1):E146-50. PMCID: 3038481.

Hematopoietic Lineage Cell-Specific Protein 1 Functions in Concert with the Wiskott-Aldrich Syndrome Protein To Promote Podosome Array Organization and Chemotaxis in Dendritic Cells. Klos Dehring DA, Clarke F, Ricart BG, Huang Y, Gomez TS, Williamson EK, Hammer DA, Billadeau DD, Argon Y, Burkhardt JK. J Immunol. 2011.

Androgenic Influence on Serotonergic Activation of the HPA Stress Axis. Goel N, Plyler KS, Daniels D, Bale TL. Endocrinology. 2011.

Miller RA, Harrison DE, Astle CM, Baur JA, Boyd AR, de Cabo R, Fernandez E, Flurkey K, Javors MA, Nelson JF, Orihuela CJ, Pletcher S, Sharp ZD, Sinclair D, Starnes JW, Wilkinson JE, Nadon NL, Strong R. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J Gerontol A Biol Sci Med Sci. 2011;66(2):191-201. PMCID: 3021372.

Mitochondrial Protection by Resveratrol. Ungvari Z, Sonntag WE, de Cabo R, Baur JA, Csiszar A. Exerc Sport Sci Rev. 2011.

Deficiency of PTP1B in POMC neurons leads to alterations in energy balance and homeostatic response to cold exposure. De Jonghe BC, Hayes MR, Banno R, Skibicka KPPD, Zimmer DJ, Bowen KAPD, Leichner TM, Alhadeff AL, Kanoski SEPD, Cyr NE, Nillni EA, Grill HJ, Bence KK. Am J Physiol Endocrinol Metab. 2011.

Intracellular Signals Mediating the Food Intake-Suppressive Effects of Hindbrain Glucagon-like Peptide-1 Receptor Activation. Hayes MR, Leichner TM, Zhao S, Lee GS, Chowansky A, Zimmer D, De Jonghe BC, Kanoski SE, Grill HJ, Bence KK. Cell Metab. 2011;13(3):320-30.

Gene Therapy in Ophthalmology: Validation on Cultured Retinal Cells and Explants from Postmortem Human Eyes. Fradot M, Busskamp V, Forster V, Cronin T, Leveillard T, Bennett J, Sahel JA, Roska B, Picaud S. Hum Gene Ther. 2011.

Suppression and Replacement Gene Therapy for Autosomal Dominant Disease in a Murine Model of Dominant Retinitis Pigmentosa. Millington-Ward S, Chadderton N, O'Reilly M, Palfi A, Goldmann T, Kilty C, Humphries M, Wolfrum U, Bennett J, Humphries P, Kenna PF, Farrar GJ. Mol Ther. 2011.

Genomics: Drugs, diabetes and cancer. Birnbaum MJ, Shaw RJ. Nature. 2011;470(7334):338-9.

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. JM, Wade MR, Tenorio VM, Kuo MS, Brozinick JT, Zhang BB, Birnbaum MJ, Summers SA, Scherer PE. Nat Med. 2011;17(1):55-63.