• Purified human CD8 T-cells

    Erin Zwack/Brodsky Lab & Penn Vet Imaging Core - Murine macrophages infected with Yersinia pseudo tuberculosis. Blue indicates the cell, red is a mitochondrial stain, green is a stain for Yersinia secreted effector proteins.

  • 3D image of the inflamed meningeal membrane of a CX3CR1-GFP reporter mouse

    Claudio Giraudo - Polarization of lytic granules to the immunological synapse during the cytolytic process of human CD8 lymphocytes against cancer cells.

  • Time series of cells expressing GFP-tagged ebola viral protein VP40

    Gretchen Harms, Hunter lab - Stylized images of CD8+ T cells looking at differential localization of the transcription factor T-bet in mouse cells after infection with the parasite Toxoplasma gondii, using the Amnis ImageStream. In the cell in the first and third box, T-bet (red) does not co-localize with DAPI (blue), indicating that it is cytoplas

Penn Institute for Immunology 2014 Catalyst Pilot Grant Program RFA

The Penn Institute for Immunology is announcing a Pilot Grant Program to foster competitive multi-investigator grant proposals. The specific scientific focus of pilot grant applications is non-restrictive, but applications that highlight the use of cutting edge technology, novel computation approaches, translation immunology or infectious disease are strongly encouraged. Importantly, pilot grants that are responsive to an upcoming RFA, future NIH Concept or other future funding mechanism (partial list included in Appendix) will be a priority. A specific plan should be articulated for how the pilot funding will position the investigator(s) to compete more effectively for a future multi-investigator application. The science remains a priority; however, it is important to emphasize the missing piece in preliminary data, etc. that this pilot grant will fill to enable a strong application.

Important Dates:
  • Submission deadline for full applications: May 15, 2014
  • Awards made by: June 16, 2014

It is anticipated that up to 2-3 pilots will be awarded. Applications may request up to $75,000 in support for one year. 

  • All faculty members of the Penn IFI are invited to submit proposals.
  • Full applications must be submitted by email to Kaitlyn Piazza (kbaraldi@mail.med.upenn.edu) by 15 May 2014
Full Application Instructions:

A single PDF should include the following:

  • Cover page: includes abstract of up to 250 words and list of approved or pending IACUC/IRB protocols [see attached cover page that should be included in each application]. 
  • Application (Aims, Significance and Innovation, Preliminary Results and Experimental Design). Limited to two pages including all preliminary data (excluding references; references can be on additional pages). 
  • Applicants should include an additional half page section devoted to explaining how pilot funds will enable a strong, competitive application to a larger funding mechanism (e.g. multi-investigator NIH application)
  • NIH biographical sketch for each investigator 
  • NIH other support for each investigator 
  • Budget and justification: one year, up to a maximum of $75,000; one page only
Award Terms
  1. Awardees are required to inform the IFI in the event that the Pilot/Feasibility Project receives external funding during the project period.
  2. A final progress report is due one month after the close of the project period. The report will contain a one-page synopsis of scientific progress and a list of resulting collaborations, publications, and grants.
  3. Awardees will provide interim reports concerning other support, resulting publications, and research activities for the IFI annual retreat and continuation applications.
  4. Awardees will also be required to present their work at the 2015 IFI Year in Review.  For additional information, please contact: Kaitlyn Piazza (kbaraldi@mail.med.upenn.edu