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Embryo photos [Click image to see larger version.]

The liver-less mouse:
Foxa1-/-; Foxa2LoxP/LoxP; Foxa3-Cre embryos fail to initiate the hepatic program. AFP expression is detected in the control E9.5 embryo (left), but not in the Foxa1-/-; Foxa2LoxP/LoxP; Foxa3-Cre double mutant (right).

 

Penn Genetics Kaestner Page

Beta Cell Biology Consortium (BCBC)

Functional Genomics Core (FGC)

GLITR ChIP-Seq Analysis Program

 

Kaestner Lab

School of Medicine Department of Genetics

The Kaestner lab is employing modern mouse genetic approaches, such as gene targeting, tissue-specific and inducible gene ablation, to understand the molecular mechanisms of organogenesis and physiology of the liver, pancreas and gastrointestinal tract.

Research interests includes:

Header Image:
Deletion of Foxa2 in Foxa2 loxP/loxP; Foxa3Cre mice. Efficiency and timing of Foxa2 deletion by Foxa3Cre were evaluated by immunofluorescence. Expression of Foxa2 was assessed by immunofluorescence in the P3 pancreas. Insulin (green) and Foxa2 (red) were found in the control pancreas (left), while Foxa2 protein was completely deleted in both islets and acini in the Foxa2 loxP/loxP; Foxa3Cre pancreas (right).

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