Current Grant Support

NIH R21 DK132556

MRI-Based Renal Oximetry in Early Diabetic Kidney Disease

To assess renal MRO₂ as a marker of early-stage diabetic kidney disease through quantification of renal MRO₂, eGFR, and microalbuminuria in prediabetic and type-2 diabetic patients in comparison to healthy reference subjects. (PI: F.W. Wehrli)

NIH R21 EB031364

MRI-Based Regional Assessment of Cerebral Metabolism Via 3D Quantitative BOLD 

To develop and validate a MRI-based method for robust 3D mapping of oxygen metabolism across the entire brain, with the long-term goal of the method’s translation to the clinic for evaluating patients with neurometabolic disorders and providing guidance to clinical management. (PI: F.W. Wehrli)

NIH R01 NS131235

Simultaneous PET/MR Imaging of Brain Glucose and Oxygen Metabolism to Assess Energy Deficits Related to Alzheimer’s Disease and the Response to Intervention

To develop clinically practical, noninvasive imaging methods based on combined positron emission tomography and magnetic resonance imaging to assess brain energy to better understand how this critical component of brain health is impacted by aging.T (PI: F.W. Wehrli, Keith St. Lawrence)

NIH R01 HL155243

MRI and Biological Markers of Acute E-Cigarette Exposure in Smokers and Vapers

To provide new insight into the acute effects of e-cigarette aerosol inhalation in the presence and absence of nicotine in terms of markers of endothelial dysfunction and oxidative stress, both at the holistic and cellular level. (PI: F.W. Wehrli)

NIH R01 AR050068 

Bone Water and Mineralization Measured by Nuclear Magnetic Resonance 

To provide a path toward clinical assessment of cortical bone health as well as the effectiveness of drug intervention in patients with osteoporosis. (PI: F.W. Wehrli)

NIH T32 EB020087 

Training in Structural, Physiologic and Functional MRI 

To train predoctoral candidates in MRI physics and engineering, with particular focus on structural, physiologic and functional applications, for a period of two years. (PI: F.W. Wehrli)

NIH P41 EB029460

Center for Advanced Metabolic Imaging in Precision Medicine 

To establish a national resource focused on imaging biomarkers of metabolism in the brain and other tissues. (PI: R.R. Reddy / TR&D 2 Core Leader: F.W. Wehrli)

NIH R01 AR076392 

MRI Assessment of Hip Fracture Risk and Therapy Response in HIV/HCV Coinfection 

To change and improve how bone disease is clinically managed and to reduce the burdens of hip fracture in patient infected with HIV and HCV. (PI: C.S. Rajapakse)

NIH R01 AI036626

Changes in Bone Quality, Sarcopenia and Fat Distribution in HIV/HCV Patients After HCV Therapy 

To compare at enrollment across three cohorts of patients (HIV/HCV initiating direct-acting antiviral (DAA) therapy, HCV initiating DAAs, uninfected persons): muscle mass/strength, MRI measures of subcutaneous, visceral and intra-hepatic fat, bone quality via high-resolution peripheral quantitative CT, and insulin resistance, and to then examine changes in the outcomes of coinfected and HCV only patients, from DAA initiation to 12 months after HCV cure (18 months) in comparison to changes in uninfected persons over 18 months. (PI: V. Lo Re / Subcontract PI: C.S. Rajapakse)

NIH R01 AR073851 

MRI of Proximal Femur Bone Quality for Monitoring Short-Term Response to Osteoporosis Therapy

To investigate the feasibility of using high-resolution MRI for monitoring short-term treatment response on bone microstructure compared to standard-of-care-test DXA. (PI: G. Chang / Subcontract PI: C.S. Rajapakse)

National Science Foundation  / Collaborative Research Grant 

Uncovering the Multiscale Determinants of Atypical Femoral Fracture using MRI and CT-Based Modeling 

To develop a multi-scale imaging and finite element model for getting insight into atypical femur fracture. (PI: C.S. Rajapakse)

Department of Defense  / Translational Research Partnership Award 

MRI Biomarkers of Bone Quality in Duchenne Muscular Dystrophy 

To evaluate the reproducibility, disease-related changes, and responsiveness to change of qMR measures of bone quality, and quantify the effect of individual subject characteristics (age, ambulatory status, and muscle disease severity) that impact bone quality in DMD. (Initiating PI: R. Willcocks / Partnering PI C.S. Rajapakse)