Perelman School of Medicine at the University of Pennsylvania

Wenqin Luo Lab

  • crest
  • Banner 1
  • Banner Image 3
  • Banner 4
  • Banner 2


Research in the Luo lab is aimed at understanding the neurobiology of somatosensation. Broadly speaking, the lab uses the mouse as a model organism to focus on the following questions:

  • What are the functional circuits governing the expression of touch, pain, and itch behaviors, and what are the molecular and cellular mechanisms underlying these circuits?
  • What salient molecular, behavioral, and cognitive features allow for the differentiation between responses to pain and itch?
  • How is somatosensory information coded and conveyed at anatomical, molecular, and circuit levels?
  • What molecular and circuit level changes are associated with the manifestation of pathological conditions of pain often seen in human disease?
  • What are the molecular and cellular mechanisms regulating the development of somatosensory circuits?

Our work employs a wide variety of cellular and molecular techniques, mouse genetic tools, mouse behavior assays, and physiological recordings to help us answer these questions. Please do not hesitate to contact members of our lab if you are interested in learning more about our research!

News and Announcements


Another month, another new graduate student! Suna Li has joined the lab after her rotation last summer! Welcome!


More congrats, this time to graduate student Will Olson, research associate Lian Cui, postdoc Ishmail Abdus-Saboor, and undergrad Justin Burdge for their paper «Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors», which was accepted for publication in eLife!


Congrats to graduate student Peter Dong, whose paper «TRPC3 is dispensable for β-alanine triggered acute itch» was accepted for publication in Scientific Reports!