Univ. of Pennsylvania Penn's Neurobiology of Disease Curriculum

FELLOWSHIPS available to train in Translational Research in NBD
INSC 600-002

T/R 10:30-noon; 1st half of Spring 2009

Module Overview

A bench-to-bedside presentation of the molecular mechanisms of acute nervous system injury, therapeutic strategies for intervention, and clinical applications of neuroprotection.

Module Goals

Most sessions will discuss: a) mechanisms of injury; b) targets for therapy and past clinical trials; c) development of future treatments via new clinical trials.

Assigned Readings

Papers from the primary literature will be assigned weekly and be presented by teams of students during the Friday course sessions. There will be no lecture on these days. Students will read the background readings and generate questions to be used during the in-class discussion. <

Viewing the Lectures from 2009

From a PC: Just click on the link
From a Mac: download - just once - a copy of silverlight.

Lectures - Spring 2009

Topic Speaker Date Video/Slide Presentation
Introduction Neumar Jan 15 Video/Slides
Cell death pathways Siman Jan 20 Video/Slides
Ca-activated Proteases Neumar Jan 27 Video/Slides
Oxidative Stress Ischiropolous Feb 3 Video/Slides
Excitotoxicity Robinson Feb 10 Video/Slides
Inflammation Kariko Feb 17 Video/Slides
Endogenous protection Welsh Feb 24 Video/Slides
Pharmacological Protection Greenberg Mar 3 Video/Slides


Viewing the Lectures from 2007

For helpful hints on viewing the videotaped lectures go HERE.
You will need RealPlayer to view the videos. Make sure to click "Free Download."

Lectures - Spring 2007

Date Subject-Lecturer Real
10-Jan: Overview-Neumar/Welsh link to video link to slides
slides 9,10,11
17-Jan: Excitotoxicity-Robinson link to video link to slides
24-Jan: Cell death pathways-Siman link to video link to slides
31-Jan: Oxidative stress-Ischiropolous link to video link to slides
7-Feb: Role of Calpains in Acute Brain Injury-Neumar
link to video link to slides
14-Feb: SNOW DAY!    
16-Feb: Inflammation-Kariko link to video link to slides
21-Feb: Preconditioning-Welsh link to video link to slides