Morgan DeSantis graduated from the College of Wooster with a BA in Biochemistry/Molecular Biology (2005). After three years at the NCI, Morgan joined the BMB graduate program at Penn. Morgan was a CBI Fellow (2009-2012). In 2012, Morgan was awarded a Ruth L. Kirschstein National Research Service Award (NRSA) from the National Institute of Neurological Disorders and Stroke (NINDS).

Publications

DeSantis, M.E., and J. Shorter. (2012). Hsp104 Drives ''Protein-Only'' Positive Selection of Sup35 Prion Strains Encoding Strong [PSI+]. Chemistry & Biology. 19:1400-1410. pdf file link

DeSantis, M.E., E.H. Leung, E.A. Sweeny, M.E. Jackrel, M. Cushman-Nick, A. Neuhaus-Follini, S. Vashist, M.A. Sochor, M.N. Knight, and J. Shorter. (2012). Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Nonamyloid Clients. Cell. 151:778-793. pdf file link

Acchione, M., Y.C. Lee, M.E. DeSantis, C.A. Lipschultz, A. Wlodawer, M. Li, A. Shanmuganathan, R.L.Walter, S.J. Smith-Gill, and J.J. Barchi. (2012). Specific Fluorine Labeling of HyHEL-10 Antibody Affects Antigen Binding and Dynamics. Biochemistry. 51 (30): 6017–6027. pdf file link

DeSantis, M.E. and J. Shorter. (2012). The elusive middle domain of Hsp104 and ClpB: location and function. Biochimica et Biophysica Acta.1823(1): 29-39. pdf file link

Sweeny, E.A., M.E. DeSantis and J. Shorter. (2011). Purification of Hsp104, a protein disaggregase. J. Vis. Exp.(55), e3190, DOI: 10.3791/3190 pdf file link

DeSantis M.E.^ and Dersh D. (2010). Preventing Parkinson's pathology. Dis. Model Mech. 3: 399-400. pdf file link (^Co-corresponding author)

Mohan S., Kourentzi K., Schick K.A., Uehara C., Lipschultz C.A, Acchione M., DeSantis M.E., Smith-Gill S.J. and Willson R.C. (2009). Association Energetics of Cross-Reactive and Specific Antibodies. Biochemistry. 48 (6): 1390–1398 pdf file link

Acchione M., Lipschultza C.A., DeSantis M.E., Shanmuganathana A., Lib M., Wlodawerb A., Tarasovd S. and Smith-Gill S.J. (2009). Light chain somatic mutations change thermodynamics of binding and water coordination in the HyHEL-10 family of antibodies. Mol. Immunol. 47 (2-3):457-464 pdf file link