Elizabeth Sweeny was a graduate student in the Department of Biochemistry and Biophysics. She has a BS from Loyola University Chicago (2007) in Chemistry. She is originally from Minnesota. In 2009 and 2013, Elizabeth won the A. Joshua Wand Prize for best poster at the B&B/BMB Retreat. In 2010, Elizabeth was awarded an American Heart Association Predoctoral fellowship. Elizabeth was a CBI scholar. Elizabeth defended her Ph.D. thesis: 'Structural and mechanistic insights into the yeast disaggrgease Hsp104' in April, 2014. Elizabeth went on to pursure her post-doctoral studies with Chris Voigt at MIT.


Gates, S.N*., A.L. Yokom*, J. Lin, M.E. Jackrel, A.N. Rizo, N.M. Kendsersky, C.E. Buell, E.A. Sweeny, K.L. Mack, E. Chuang, M.P. Torrente, M. Su, J. Shorter, and D.R. Southworth. (2017). Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science. 357(6348):273-279. pdf file link (*Co-first author).

Weaver, C.L., E.C. Duran, K.L. Mack, J. Lin, M.E. Jackrel, E.A. Sweeny, J. Shorter, and A.L. Lucius. (2017). Avidity for polypeptide binding by nucleotide-bound Hsp104 structures. Biochemistry. 56(15):2071–2075. pdf file link

Sweeny, E.A., and J. Shorter. (2016). Mechanistic and structural insights into the prion-disaggregase activity of Hsp104. J. Mol. Biol. 428(9):1870-1885. pdf file link

Sweeny, E.A., M.E. Jackrel, M.S. Go, M.A. Sochor, B.M. Razzo, M.E. DeSantis, K. Gupta, and J. Shorter. (2015). The Hsp104 N-terminal domain enables disaggregase plasticity and potentiation. Mol. Cell. 57(5):836-849. pdf file link

DeSantis, M.E., E.A. Sweeny, D. Snead, E.H. Leung, M.S. Go, K. Gupta, P. Wendler, and J. Shorter. (2014). Conserved distal loop residues in the Hsp104 and ClpB middle domain contact nucleotide-binding domain 2 and enable Hsp70-dependent protein disaggregation. J. Biol. Chem. 289(2):848-867. pdf file link

DeSantis, M.E., E.H. Leung, E.A. Sweeny, M.E. Jackrel, M. Cushman-Nick, A. Neuhaus-Follini, S. Vashist, M.A. Sochor, M.N. Knight, and J. Shorter. (2012). Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Non-Amyloid Clients. Cell. 151:778-793. pdf file link

Sweeny, E.A., M.E. DeSantis and J. Shorter. (2011). Purification of Hsp104, a protein disaggregase. J. Vis. Exp.(55), e3190, DOI: 10.3791/3190 pdf file link

Roberts B.E., M.L. Duennwald, H. Wang, C. Chung, N.P. Lopreiato, E.A. Sweeny, M.N. Knight and J. Shorter. (2009). A synergistic small-molecule combination directly eradicates diverse prion strain structures. Nat. Chem. Biol. 5(12):936-946. pdf file link

Sweeny, E.A. and J. Shorter. (2008). Prion proteostasis: Hsp104 meets its supporting cast. Prion. 2(4): 135-40. pdf file link





Department of Biochemistry & Biophysics
University of Pennsylvania