Welcome to the Wellen Lab at the University of Pennsylvania
Cells rely on accurate assessment of nutrient availability in order to make decisions about growth and proliferation, differentiation and function, and even their own survival. Our laboratory’s research aims to elucidate mechanisms of crosstalk between metabolic pathways, signaling networks, and the epigenome. We have shown that acetylation of histones is sensitive to acetyl-CoA availability in diverse mammalian cell types and that metabolic reprogramming in cancer cells can alter the production of acetyl-CoA and histone acetylation in tumor cells. Current projects in the lab are investigating the regulation of acetyl-CoA production and utilization, the biological processes controlled by nutrient-sensitive acetylation, and approaches for exploiting acetyl-CoA metabolism to improve cancer therapy.
New review article published: Metabolic Signaling to the Nucleus in Cancer, Mol Cell. 2018 Aug 2;71(3):398-408. Great work Sydney!