Publications

Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma.
Kader T, Lin JR, Hug CB, Coy S, Chen YA, de Bruijn I, Shih N, Jung E, Pelletier RJ, Lopez Leon M, Mingo G, Omran DK, Lee JS, Yapp C, Satravada BA, Kundra R, Xu Y, Chan S, Tefft JB, Muhlich JL, Kim SH, Gysler SM, Agudo J, Heath JR, Schultz N, Drescher CW, Sorger PK, Drapkin R*, Santagata S*. *co-senior authors:
Cancer Discovery 2025 Jun 3;15(6):1180-1202.

Impact of BRCA mutations, age, surgical indication, and hormone status on the molecular phenotype of the human Fallopian tube.
Beddows I, Djirackor S, Omran DK, Jung E, Shih NN, Roy R, Hechmer A, Olshen A, Adelmant G, Tom A, Morrison J, Adams M, Rohrer DC, Schwartz LE, Pearce CL, Auman H, Marto JA, Drescher CW*, Drapkin R*, Shen H*. * ‎co-corresponding senior authors
Nature Communications 2025 Mar 26; 16(1): 2981.

LINE-1 ORF1p expression occurs in clear cell ovarian carcinoma precursors and is a candidate blood biomarker.
de Santiago PR, Sato S, Zhang SJ, Dougher MC, Devins KM, Bilecz AJ, Rayamajhi S, Mingo G, Rendulich HS, Feng Y, Wu C, Taylor MS, Zhuravlev Y, Jung E, Omran DK, Wang TL, Shih IM, Schwartz LE, Kim S, Morgan MA, Tanyi JL, Burns KH, Lengyel E, Parra-Herran C, Godwin AK, Walt DR, Drapkin R.
NPJ Precision Oncology 2025 Mar 6;9(1):62.

Aged and BRCA-Mutated Stromal Cells Drive Epithelial Cell Transformation
Garcia GL, Orellana T, Gorecki G, Frisbie L, Baruwal R, Suresh S, Goldfeld E, Beddows I, MacFawn IP, Britt AK, Hale MM, Elhaw AT, Isett BR, Hempel N, Bao R, Shen H, Buckanovich RJ, Finkel T, Drapkin R, Soong TR, Bruno TC, Atiya HI, Coffman LG.
Cancer Discovery 2025 Jun 3;15(6):1203-1224.

Repurposing Colforsin Daropate to Treat MYC-driven High-Grade Serous Ovarian Carcinomas.
Knarr MJ, Moon J, Rawat P, DiFeo A, Hoon DSB, Drapkin R.
Science Signaling 2024 Nov 19;17(863):eado8303.

Early Detection of Ovarian Cancer Using Cell-Free DNA Fragmentomes and Protein Biomarkers.
Medina JE, Annapragada AV, Lof P, Short S, Bartolomucci AL, Mathios D, Koul S, Niknafs N, Noe M, Foda ZH, Bruhm DC, Hruban C, Vulpescu NA, Jung E, Dua R, Canzoniero JV, Cristiano S, Adleff V, Symecko H, van den Broek D, Sokoll LJ, Baylin SB, Press MF, Slamon DJ, Konecny GE, Therkildsen C, Carvalho B, Meijer GA, Andersen CL, Domchek SM, Drapkin R, Scharpf RB, Phallen J, Lok CAR, Velculescu VE.
Cancer Discovery 2025 Jan 13;15(1):105-118.

Ultrasensitive detection of circulating LINE-1 ORF1p as a specific multi-cancer biomarker.
Taylor MS, Wu C, Fridy PC, Zhang SJ, Senussi Y, Wolters JC, Cajuso T, Cheng WC, Heaps JD, Miller BD, Mori K, Cohen L, Jiang H, Molloy KR, Chait BT, Goggins MG, Bhan I, Franses JW, Yang X, Taplin ME, Wang X, Christiani DC, Johnson BE, Meyerson M, Uppaluri R, Egloff AM, Denault EN, Spring LM, Wang TL, Shih IM, Fairman JE, Jung E, Arora KS, Yilmaz OH, Cohen S, Sharova T, Chi G, Norden BL, Song Y, Nieman LT, Pappas L, Parikh AR, Strickland MR, Corcoran RB, Mustelin T, Eng G, Yilmaz OH, Matulonis UA, Skates SJ, Rueda BR, Drapkin R, Klempner SJ, Deshpande V, Ting DT, Rout MP, LaCava J, Walt DR, Burns KH.
Cancer Discovery 2023 Sep 12. Epub ahead of print. PMID: 37698949.

Aneuploidy landscape in precursors of ovarian cancer.
Wang Y, Douville C, Chien YW, Wang BG, Chen CL, Pinto A, Smith, SA, Murdock T, Drapkin R, Vang R, Chui MH, Numan T, Vang R, Papadopoulos N, Wang TL, Shih IM.
Clin Cancer Res,30(3): 600-615. 2024. PMID: 38048050.  

Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells.
Reavis, H. D., Gysler, S. M., McKenney, G. B., Knarr, M., Lusk, H. J., Rawat, P., Rendulich, H. S., Mitchell, M. A., Berger, D. S., Moon, J. S., Ryu, S., Mainigi, M., Iwanicki, M. P., Dave S.B. Hoon, Sanchez, L. M., & Drapkin, R.
JCI Insight, 9(5). 2024 Jan 25. PMID: 38271085.

Morphological and molecular heterogeneity of high-grade serous carcinoma precursor lesions.
Chein YW, Wang Y, Huang P, Lawson BC, Kolin DL, Chui MH, Vang R, Numan TA, Soong TR, Wang BG, Smith SA, Chen CL, Stone R, Douville C, Wang TL, Shih IM.
Am J Surg Pathol, 48:475-486. 2024 Feb 1. PMID: 38298022.