Kyong-Mi Chang, MD
Professor of Medicine (Gastroenterology)
Faculty, Center for AIDS Research, University of Pennsylvania Perelman School of Medicine
Faculty, Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania Perelman School of Medicine
Faculty, Abramson Cancer Center, University of Pennsylvania Perelman School of Medicine
Associate Dean for Research at Crescenz VAMC, Philadelphia, University of Pennsylvanina Perelman School of Medicine
Member, Internal Advisory Board, P30 Center for Molecular Studies in Digestive and Liver Diseases, University of Pennsylvania Perelman School of Medicine
Co-Director, Liver Club for NIDDK Center for Molecular Studies in Digesetive and Liver Diseases, University of Pennsylvania Perelman School of Medicine
Department: Medicine
Graduate Group Affiliations
Contact information
Corporal Michael J. Crescenz VAMC &
University of Pennsylvania Perelman School of Medicine
3900 Woodland Avenue
Philadelphia, PA 19104
University of Pennsylvania Perelman School of Medicine
3900 Woodland Avenue
Philadelphia, PA 19104
Office: (215) 823-5893
Lab: (215) 823-5800 ext 6730
Lab: (215) 823-5800 ext 6730
Publications
Links
Search PubMed for articles
Cell and Molecular Biology graduate group faculty webpage.
Primary Work Website
Corporal Michael J. Crescenz VA Medical Center
Penn Medicine Liver Diseases Program
Search PubMed for articles
Cell and Molecular Biology graduate group faculty webpage.
Primary Work Website
Corporal Michael J. Crescenz VA Medical Center
Penn Medicine Liver Diseases Program
Education:
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
M.D.
The Medical College of Pennsylvania, 1987.
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
M.D.
The Medical College of Pennsylvania, 1987.
Post-Graduate Training
General Surgery Internship, St. Francis Hospital/University of Connecticut, 1987-1988.
Family Practice Internship, Underwood Memorial Hospital/Thomas Jefferson University, Philadelphia, PA, 1988-1989.
Internal Medicine Residency, The Medical College of Pennsylvania, Philadelphia, PA, 1989-1992.
Gastroenterology Fellowship, Division of Gastroenterology, University of California at San Diego, 1992-1995.
NRSA Research Fellow (UCSD GI Division), Laboratory of Dr. Francis V Chisari, The Scripps Research Institute, La Jolla, CA, 1993-1995.
Research Associate/Sr Research Associate, Laboratory of Dr. Francis V Chisari, The Scripps Research Institute, La Jolla, CA, 1995-1999.
General Surgery Internship, St. Francis Hospital/University of Connecticut, 1987-1988.
Family Practice Internship, Underwood Memorial Hospital/Thomas Jefferson University, Philadelphia, PA, 1988-1989.
Internal Medicine Residency, The Medical College of Pennsylvania, Philadelphia, PA, 1989-1992.
Gastroenterology Fellowship, Division of Gastroenterology, University of California at San Diego, 1992-1995.
NRSA Research Fellow (UCSD GI Division), Laboratory of Dr. Francis V Chisari, The Scripps Research Institute, La Jolla, CA, 1993-1995.
Research Associate/Sr Research Associate, Laboratory of Dr. Francis V Chisari, The Scripps Research Institute, La Jolla, CA, 1995-1999.
Certifications
Diplomate, National Board of Medical Examiners, 1988.
American Board of Internal Medicine, 1992.
Gastroenterology Board Certification, 1995.
Gastroenterology Board Recertification, 2016.
Permanent linkDiplomate, National Board of Medical Examiners, 1988.
American Board of Internal Medicine, 1992.
Gastroenterology Board Certification, 1995.
Gastroenterology Board Recertification, 2016.
Description of Research Expertise
Dr. Chang's research expertise is in immune mechanisms of viral persistence and disease pathogenesis with a focus on human hepatitis C and B viruses, +/- HIV confection. As the PI of a VA Merit award using the VA's Million Veterans Program (MVP), Dr. Chang is also conducting population-based genomic analyses of cardiometabolic disorders including MASLD/NAFLD and liver disease progression to cirrhosis and HCC--in collaboration with other large national and international genomic cohorts.Selected Publications
Callans LE, Ivey KL, Chang KM, Kaplan DE; VA Million Veteran Program.: Diet composition impacts the natural history of steatotic liver disease. Hepatol Commun 9: e0754, Jun 2025.Adkar SS, Lynch J, Choi RB, Roychowdhury T, Judy RL, Paruchuri K, Go DC, Bamezai S, Cabot J, Sorondo S, Levin MG, Milewicz DM, Willer CJ, Natarajan P, Pyarajan S, Chang KM, Damrauer S, Tsao P, Skirboll S, Leeper NJ, Klarin D.: Dissecting the Genetic Architecture of Intracranial Aneurysms. Circ Genom Precis Med Jun 2025.
Chanfreau-Coffinier C, Friede KA, Plomondon ME, Lee KM, Lu Z, Dinatale T, DuVall SL, Vassy JL, Waldo SW, Cleator JH, Maddox TM, Rader DJ, Assimes TL, Damrauer SM, Tsao PS, Chang KM, Voora D, Lynch JA, Giri J; VA Million Veteran Program; Tuteja S.: CYP2C19 Polymorphisms and Clinical Outcomes Following Percutaneous Coronary Intervention in the Million Veteran Program. Clin Pharmacol Ther Jun 2025.
Traum D, Wong DK, Lau DT, Sterling RK, Terrault NA, Khalili M, Wahed AS, Lee WM, Block TM, Lok ASF, Chang KM; Hepatitis B Research Network (HBRN).: HBV-specific T-cell function is nonenhanced by tenofovir-induced decline in HBV viremia or HBsAg titer in chronic hepatitis B. Hepatol Commun 9: e0694, May 2025.
Li X, Pakanati V, Liu C, Wang T, Morelli D, Korpak A, Baraff A, Isaacs SN, Vittor A, Chang KM, Le E, Smith NL, Lee JS, Ross JM, Shah JA; EPIC3 Investigators.: Peripheral blood cytokine profiles predict the severity of SARS-CoV-2 infection: an EPIC(3) study analysis. BMC Infect Dis 25: 677, May 2025.
Sanchez Vasquez JD, Nkongolo S, Traum D, Sotov V, Kim SC, Mahamed D, Mehrotra A, Patel A, Chen DY, Fung S, Gaggar A, Feld JJ, Chang KM, Wallin JJ, Wang BX, Janssen H, Gehring AJ.: Virus-associated inflammation imprints an inflammatory profile on monocyte-derived macrophages in the human liver. J Clin Invest 135: e175241, Apr 2025.
Rios Coronado PE, Zhou J, Fan X, Zanetti D, Naftaly JA, Prabala P, Martínez Jaimes AM, Farah EN, Kundu S, Deshpande SS, Evergreen I, Kho PF, Ma Q, Hilliard AT, Abramowitz S, Pyarajan S, Dochtermann D; Million Veteran Program; Damrauer SM, Chang KM, Levin MG, Winn VD, Paşca AM, Plomondon ME, Waldo SW, Tsao PS, Kundaje A, Chi NC, Clarke SL, Red-Horse K, Assimes TL.: CXCL12 drives natural variation in coronary artery anatomy across diverse populations. Cell 188: 1784-1806, Apr 2025.
Zhang X, Brody JA, Graff M, Highland HM, Chami N, Xu H, Wang Z, Ferrier KR, Chittoor G, Josyula NS, Meyer M, Gupta S, Li X, Li Z, Allison MA, Becker DM, Bielak LF, Bis JC, Boorgula MP, Bowden DW, Broome JG, Buth EJ, Carlson CS, Chang KM, Chavan S, Chiu YF, Chuang LM, Conomos MP, DeMeo DL, Du M, Duggirala R, Eng C, Fohner AE, Freedman BI, Garrett ME, Guo X, Haiman C, Heavner BD, Hidalgo B, Hixson JE, Ho YL, Hobbs BD, Hu D, Hui Q, Hwu CM, Jackson RD, Jain D, Kalyani RR, Kardia SLR, Kelly TN, Lange EM, LeNoir M, Li C, Le Marchand L, McDonald MN, McHugh CP, Morrison AC, Naseri T; NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium; O'Connell J, O'Donnell CJ, Palmer ND, Pankow JS, Perry JA, Peters U, Preuss MH, Rao DC, Regan EA, Reupena SM, Roden DM, Rodriguez-Santana J, Sitlani CM, Smith JA, Tiwari HK, Vasan RS, Wang Z, Weeks DE, Wessel J, Wiggins KL, Wilkens LR, Wilson PWF, Yanek LR, Yoneda ZT, Zhao W, Zöllner S, Arnett DK, Ashley-Koch AE, Barnes KC, Blangero J, Boerwinkle E, Burchard EG, Carson AP, Chasman DI, Ida Chen YD, Curran JE, Fornage M, Gordeuk VR, He J, Heckbert SR, Hou L, et al.: Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele. Nat Commun 16: 3470, Apr 2025.
Sevilla-González M, Smith K, Wang N, Jensen AE, Litkowski EM, Kim H, DiCorpo DA, Hsu S, Cui J, Liu CT, Yu C, McNeil JJ, Lacaze P, Westerman KE, Chang KM, Tsao PS, Phillips LS, Goodarzi MO, Sladek R, Rotter JI, Dupuis J, Florez JC, Merino J, Meigs JB, Zhou JJ, Raghavan S, Udler MS, Manning AK.: Heterogeneous effects of genetic variants and traits associated with fasting insulin on cardiometabolic outcomes. Nat Commun 16: 2569, Mar 2025.
Yang G, Alarcon C, Chanfreau C, Lee NH, Friedman P, Nutescu E, Tuck M, O'Brien T, Gong L, Klein TE, Chang KM, Tsao PS, Meltzer DO, Lynch JA; Million Veteran Program; Tuteja S, Perera MA.: Investigation of Genomic and Transcriptomic Risk Factors of Clopidogrel Response in African Americans. Clin Pharmacol Ther January 2025.
