Scott Michael Gordon, MD, PhD
Assistant Professor of Pediatrics (Neonatology & Newborn Services)
Department: Pediatrics
Graduate Group Affiliations
Contact information
Children's Hospital of Philadelphia
Abramson Pediatric Research Center
3615 Civic Center Blvd
11th Floor, Office 1107C
Philadelphia, PA 19104
Abramson Pediatric Research Center
3615 Civic Center Blvd
11th Floor, Office 1107C
Philadelphia, PA 19104
Office: 503-807-7980
Publications
Education:
BS (Biology)
Haverford College, 2006.
Ph.D. (Immunology)
University of Pennsylvania School of Medicine, 2011.
M.D.
University of Pennsylvania School of Medicine, 2013.
Permanent linkBS (Biology)
Haverford College, 2006.
Ph.D. (Immunology)
University of Pennsylvania School of Medicine, 2011.
M.D.
University of Pennsylvania School of Medicine, 2013.
Description of Research Expertise
The Gordon Lab wants to know how the maternal immune system and the developing placenta communicate with each other. Historically, the maternal-fetal interface has been viewed in the same light as other immune-privileged sites in the body, to explain why a mother’s immune system doesn’t view the fetus as a partially foreign organ and reject it. In truth, the maternal-fetal interface is loaded with immune cells that directly interact with fetal cells throughout pregnancy. Likewise, a growing list of inflammatory molecules released by immune cells play key roles to support a healthy pregnancy. If we can understand how these molecules send signals back and forth between mom and fetus, we may be able to change the course of such life-threatening conditions as preeclampsia, intrauterine growth restriction, congenital infections, and premature birth.Selected Publications
Mingce Zhang, Remy R Cron, Niansheng Chu, Junior Nguyen, Scott M Gordon, Esraa M Eloseily, T Prescott Atkinson, Peter Weiser, Mark R Walter, Portia A Kreiger, Scott W Canna, Edward M Behrens, Randy Q Cron: Role of DOCK8 in cytokine storm syndromes. The Journal of Allergy and Clinical Immunology Oct 2024 Notes: DOI: 10.1016/j.jaci.2024.10.004.Shelley M. Lawrence, James L. Wynn, and Scott M. Gordon: Bacterial Sepsis. Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant, 9th Edition. Yvonne Maldonado, Victor Nizet, Elizabeth D. Barnett, Kathryn M. Edwards, Richard Malley (eds.). Elsevier, April 2024 Notes: Chapter.
Scott M. Gordon, Shelley M. Lawrence, and James L. Wynn: Bacterial Meningitis. Remington and Klein's Infectious Diseases of the Fetus and Newborn Infant, 9th Edition. Yvonne Maldonado, Victor Nizet, Elizabeth D. Barnett, Kathryn M. Edwards, Richard Malley (eds.). Elsevier, April 2024 Notes: Chapter.
Mani S, Garifallou J, Kim SJ, Simoni MK, Huh DD, Gordon SM*, Mainigi M*.: Uterine macrophages and NK cells exhibit population and gene-level changes after implantation but maintain pro-invasive properties. Front Immunol 15(1): 1364036, Mar 2024 Notes: Co-senior author.
Olivieri NR, Othman L, Flannery DD, Gordon SM.: Transmission, seroprevalence, and maternal-fetal impact of lymphocytic choriomeningitis virus. Pediatr Res 95(2): 456-463, Jan 2024.
Olivieri NR, Othman L, Gordon SM.: Health disparities revealed in a case of congenital LCMV. Pediatr Res 95(2): 579-580, Jan 2024.
Dar AA, Kim DD, Gordon SM, Klinzing K, Rosen S, Guha I, Porter N, Ortega Y, Forsyth KS, Roof J, Fazelinia H, Spruce LA, Eisenlohr LC, Behrens EM, Oliver PM.: c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8(+) T cell immunity. Nat Commun 14(1): 7098, Nov 2023.
Kanter J*, Gordon SM*, Mani S, Sokalska A, Park JY, Senapati S, Huh DD, Mainigi M.: Hormonal stimulation reduces numbers and impairs function of human uterine natural killer cells during implantation. Hum Reprod 38(6): 1047-1059, Jun 2023 Notes: Co-first author.
Burn TN, Miot C, Gordon SM, Culberson EJ, Diamond T, Kreiger PA, Hayer KE, Bhattacharyya A, Jones JM, Bassing CH, Behrens EM.: The RAG1 Ubiquitin Ligase Domain Stimulates Recombination of TCRβ and TCRα Genes and Influences Development of αβ T Cell Lineages. J Immunol 209: 938-949, Sep 2022.
Ju Young Park, Sneha Mani, Geremy Clair, Heather M. Olson, Vanessa L. Paurus, Charles K. Ansong, Cassidy Blundell, Rachel Young, Jessica Kanter, Scott M. Gordon, Alex Y. Yi, Monica Mainigi, and Dan Dongeun Huh: A microphysiological model of human trophoblast invasion during implantation. Nature Communications 3(1): 1252, Mar 2022.