Jeffrey David Roizen, M.D., Ph.D.

faculty photo
Assistant Professor of Pediatrics (Endocrinology and Diabetes)
Department: Pediatrics
Graduate Group Affiliations

Contact information
Children's Hospital of Philadelphia
Division of Endocrinology and Diabetes
3401 Civic Center Blvd.
Philadelphia, PA 19104
Office: 215-590-3174
Fax: 215-590-3053
Lab: 267 678 3597
Education:
BA (Chemistry and Biology)
Williams College, Williamstown, MA, 2000.
MD
Washington University School of Medicine, St. Louis, MO, 2008.
PhD (Molecular and Cell Biology)
Washington University School of Medicine, St. Louis, MO, 2008.
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Description of Research Expertise

The goal of our laboratory is to understand non-calciometabolic effects of vitamin D and to exploit this understanding to design new therapeutic approaches to common diseases such as sarcopenia and obesity. Towards this goal we employ a uniquely diverse toolbox of methods using large human data sets and mouse physiology combined with high throughput sequencing to drive questions in cell culture and results from unbiased screening in cell culture to drive test-of-principle experiments and trials in mice and humans. Additionally, we rely on core principles of improv (“LISTEN” (to your collagues and to the data), say “yes, and…” (if you encounter a fact that doesn’t fit your theory, follow the fact), “find the game” (what is interesting, can you set up your Qs so that any answer is interesting), “If this is true, then what else is true…” (if you find something interesting, does it imply other interesting things), “there are no mistakes” (for well designed experiments, there are no failures)) to drive our science.

Selected Publications

McCormack SE, Wang Z, Wade KL, Dedio A, Cilenti N, Crowley J, Plessow F, Bamba V, Roizen JD, Jiang Y, Stylli J, Ramakrishnan A, Platt ML, Shekdar K, Fisher MJ, Vetter VL, Hocking M, Xiao R, Lawson EA.: A Pilot Randomized Clinical Trial of Intranasal Oxytocin to Promote Weight Loss in Individuals With Hypothalamic Obesity. J Endocr Soc 7(1): bvad037, Mar 2023.

Qu HQ, Qu J, Glessner J, Liu Y, Mentch F, Chang X, March M, Li J, Roizen JD, Connolly JJ, Sleiman P, Hakonarson H.: Improved genetic risk scoring algorithm for type 1 diabetes prediction. Pediatr Diabetes 23(3): 320-323, May 2022.

Qu J, Qu HQ, Bradfield JP, Glessner JT, Chang X, Tian L, March M, Connolly JJ, Roizen JD, Sleiman PMA, Hakonarson H.: Insights into non-autoimmune type 1 diabetes with 13 novel loci in low polygenic risk score patients. Sci Rep 11(1): 16013, Aug 2021.

Mancilla EE, Zielonka B, Roizen JD, Dodds KM, Rand EB, Heimall JR, Chen F, Wu C, Goldberg DJ, Rychik J.: Growth in Children with a Fontan Circulation. J Pediatr 235(1): 149-155, Aug 2021.

Qu HQ, Qu J, Bradfield J, Glessner J, Chang X, March M, Mentch FD, Roizen JD, Connolly JJ, Sleiman P, Hakonarson H.: Combined Application of Genetic and Polygenic Risk Score for Type 1 Diabetes Risk Prediction. Diabetes Obes Metab 23(8): 2001-2003, Aug 2021.

Qu HQ, Qu J, Bradfield J, Marchand L, Glessner J, Chang X, March M, Li J, Connolly JJ, Roizen JD, Sleiman P, Polychronakos C, Hakonarson H.: Genetic architecture of type 1 diabetes with low genetic risk score informed by 41 unreported loci. Commun Biol 4(1): 908, Jul 2021.

Qu J, Qu HQ, Bradfield JP, Glessner JT, Chang X, Tian L, March ME, Roizen JD, Sleiman PM, Hakonarson H.: Association of DLL1 with type 1 diabetes in patients characterized by low polygenic risk score. Metabolism 114: 154418, Jan 2021.

Casella A, Long C, Zhou J, Lai M, O'Lear L, Caplan I, Levine MA, Roizen JD.: Differential Frequency of CYP2R1 Variants Across Populations Reveals Pathway Selection for Vitamin D Homeostasis. J Clin Endocrinol Metab 105: 1302-15, May 2020.

Roizen JD, Asada M, Tong M, Tai HH, Muglia LJ.: Early pregnancy loss in 15-hydroxyprostaglandin dehydrogenase knockout (15-HPGD(-/-)) mice due to requirement for embryo 15-HPGD activity. Sci Rep 9: 17612, Nov 2019.

Tamborlane WV, Barrientos-Pérez M, Fainberg U, Frimer-Larsen H, Hafez M, Hale PM, Jalaludin MY, Kovarenko M, Libman I, Lynch JL, Rao P, Shehadeh N, Turan S, Weghuber D, Barrett T; Ellipse Trial Investigators.: Liraglutide in Children and Adolescents with Type 2 Diabetes. N Engl J Med 381(1): 637-646, Aug 2019 Notes: Participating Investigator.

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Last updated: 12/18/2023
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