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Jeffrey David Roizen, M.D., Ph.D.
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Assistant Professor of Pediatrics (Endocrinology and Diabetes) at the Children's Hospital of Philadelphia
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Attending Physician, Division of Endocrinology & Diabetes, Children's Hospital of Philadelphia
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Department: Pediatrics
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Contact information
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Children's Hospital of Philadelphia
2e Division of Endocrinology and Diabetes
3a 3401 Civic Center Blvd.
Philadelphia, PA 19104
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2e Division of Endocrinology and Diabetes
3a 3401 Civic Center Blvd.
Philadelphia, PA 19104
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Office: 215-590-3174
32 Fax: 215-590-3053
32 Lab: 267 678 3597
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32 Fax: 215-590-3053
32 Lab: 267 678 3597
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Email:
jeffroizen@gmail.com
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jeffroizen@gmail.com
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Publications
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Links
c6 Search PubMed for articles
83 Perelman Faculty Web Page
a8 Google Scholar Page
66 CHOP faculty page
52 lab website
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c6 Search PubMed for articles
83 Perelman Faculty Web Page
a8 Google Scholar Page
66 CHOP faculty page
52 lab website
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Education:
21 7 BA 22 (Chemistry and Biology) c
3b Williams College, Williamstown, MA, 2000.
21 8 PhD 27 (Molecular and Cell Biology) c
50 Washington University School of Medicine, St. Louis, MO, 2008.
21 7 MD c
50 Washington University School of Medicine, St. Louis, MO, 2008.
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Permanent link21 7 BA 22 (Chemistry and Biology) c
3b Williams College, Williamstown, MA, 2000.
21 8 PhD 27 (Molecular and Cell Biology) c
50 Washington University School of Medicine, St. Louis, MO, 2008.
21 7 MD c
50 Washington University School of Medicine, St. Louis, MO, 2008.
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cf His clinical interests include metabolic bone diseases with a focus on vitamin D metabolism, hyperparathyroidism and pseudohypoparathyroidism as well as obesity, type 2 diabetes and type 1 diabetes.
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ae Dr. Roizen collaborates with Dr. Levine and Dr. Hakonarson. Each of whom has an active laboratory research program that complements and extends his clinical studies.
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41 Dr. Roizen has more than 30 papers, patents and chapters.
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168 He is a member of numerous professional societies, including the American Society for Bone and Mineral Research, the Endocrine Society, the Pediatric Endocrine Society and the American Diabetes Association. He is on the Editorial Board of the journal of Clinical Endocrinology and Metabolism (JCEM). He is a Fellow of the American Academy of Pediatrics.
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Description of Clinical Expertise
63 Dr. Roizen is a clinician scientist at the Children’s Hospital of Philadelphia.8
cf His clinical interests include metabolic bone diseases with a focus on vitamin D metabolism, hyperparathyroidism and pseudohypoparathyroidism as well as obesity, type 2 diabetes and type 1 diabetes.
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ae Dr. Roizen collaborates with Dr. Levine and Dr. Hakonarson. Each of whom has an active laboratory research program that complements and extends his clinical studies.
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41 Dr. Roizen has more than 30 papers, patents and chapters.
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168 He is a member of numerous professional societies, including the American Society for Bone and Mineral Research, the Endocrine Society, the Pediatric Endocrine Society and the American Diabetes Association. He is on the Editorial Board of the journal of Clinical Endocrinology and Metabolism (JCEM). He is a Fellow of the American Academy of Pediatrics.
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Description of Other Expertise
136 Dr. Roizen is a 5.0-5.5 level competitive squash player and is a past champion of the St. Louis Open Amateur Draw and past runner up in the Windy City Open Amateur Draw. He is currently ranked in the top 500 nationally in the 5.0 skill group. He has completed a half-Ironman (Santa Cruz, 2025).65
Description of Research Expertise
3ed Our lab aims to understand non-calciometabolic effects of vitamin D and to exploit this understanding to design new therapies to common diseases such as sarcopenia. Towards this goal we use large human data sets and mouse physiology combined with high throughput sequencing to drive questions in mouse models of disease and cell culture and results from unbiased screening in cell culture to drive test-of-principle experiments and trials in mice and humans. Additionally, we rely on core principles of improv (“LISTEN” (to your collagues and to the data), say “yes, and…” (if you encounter a data that doesn’t fit your model, follow the data), “find the game” (what is interesting, can you set up your Qs so that any answer is interesting), “If this is true, then what else is true…” (if you find something interesting, does it imply other interesting things), “there are no mistakes” (for well designed experiments, there are no failures)) to drive our science.e 29
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10a Nguyen, M., Roizen, J: 25(OH)D and not 1,25(OH)D is responsible for high-dose dietary vitamin D benefits in muscle. PAS Meeting, Honolulu, HI, United States. E-PAS 2025 Page: 1982764, May 2025.
116 Levine MA, Li D, Roizen J, Weber D.: Letter to the editor regarding Duan et al, "CYP4A22 loss-of-function causes a new type of vitamin D-dependent rickets (VDDR1C)" J Bone Miner Res 40: 445-446, Mar 2025.
131 Roizen J, Long C, Casella A, Nguyen M, Danahy L, Seiler C, Lei M, Mark J.: High dose dietary vitamin D allocates surplus calories to muscle and growth instead of fat via modulation of myostatin and leptin signaling. Res Sq May 2024.
fb Danahy L, Long C, Hofmann TJ, Tara Z, Mark J, Roizen JD.: Dietary vitamin D is a novel modulator of tumor engraftment through regulation of GC protein abundance. Res Sq Feb 2024.
1b3 Roizen, JD and Levine, MA: The role of genetic variation in CYP2R1, the principal vitamin D 25-hydroxylase, and CYP3A4 in vitamin D homeostasis. Feldman and Pike's Vitamin D Volume Two: Health, Disease and Therapeutics. Martin Hewison, Roger Bouillon, Edward Giovannucci, David Goltzman, Mark Meyer, JoEllen Welsh (eds.). Academic Press, Page: 341-357, Jan 2024.
1b2 McCormack SE, Wang Z, Wade KL, Dedio A, Cilenti N, Crowley J, Plessow F, Bamba V, Roizen JD, Jiang Y, Stylli J, Ramakrishnan A, Platt ML, Shekdar K, Fisher MJ, Vetter VL, Hocking M, Xiao R, Lawson EA.: A Pilot Randomized Clinical Trial of Intranasal Oxytocin to Promote Weight Loss in Individuals With Hypothalamic Obesity. J Endocr Soc 7(1): bvad037, Mar 2023.
12f Qu HQ, Qu J, Glessner J, Liu Y, Mentch F, Chang X, March M, Li J, Roizen JD, Connolly JJ, Sleiman P, Hakonarson H.: Improved genetic risk scoring algorithm for type 1 diabetes prediction. Pediatr Diabetes 23(3): 320-323, May 2022.
14b Qu HQ, Qu J, Bradfield J, Glessner J, Chang X, March M, Mentch FD, Roizen JD, Connolly JJ, Sleiman P, Hakonarson H.: Combined Application of Genetic and Polygenic Risk Score for Type 1 Diabetes Risk Prediction. Diabetes Obes Metab 23(8): 2001-2003, Aug 2021.
104 Mancilla EE, Zielonka B, Roizen JD, Dodds KM, Rand EB, Heimall JR, Chen F, Wu C, Goldberg DJ, Rychik J.: Growth in Children with a Fontan Circulation. J Pediatr 235(1): 149-155, Aug 2021.
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Selected Publications
f8 Roizen, JD and Kublaoui, B: Chapter 5: Receptor Transduction Pathways Mediating Hormone Action. Sperling Pediatric Endocrinology, 6th Edition. White, P (eds.). Elsevier, 2026.10a Nguyen, M., Roizen, J: 25(OH)D and not 1,25(OH)D is responsible for high-dose dietary vitamin D benefits in muscle. PAS Meeting, Honolulu, HI, United States. E-PAS 2025 Page: 1982764, May 2025.
116 Levine MA, Li D, Roizen J, Weber D.: Letter to the editor regarding Duan et al, "CYP4A22 loss-of-function causes a new type of vitamin D-dependent rickets (VDDR1C)" J Bone Miner Res 40: 445-446, Mar 2025.
131 Roizen J, Long C, Casella A, Nguyen M, Danahy L, Seiler C, Lei M, Mark J.: High dose dietary vitamin D allocates surplus calories to muscle and growth instead of fat via modulation of myostatin and leptin signaling. Res Sq May 2024.
fb Danahy L, Long C, Hofmann TJ, Tara Z, Mark J, Roizen JD.: Dietary vitamin D is a novel modulator of tumor engraftment through regulation of GC protein abundance. Res Sq Feb 2024.
1b3 Roizen, JD and Levine, MA: The role of genetic variation in CYP2R1, the principal vitamin D 25-hydroxylase, and CYP3A4 in vitamin D homeostasis. Feldman and Pike's Vitamin D Volume Two: Health, Disease and Therapeutics. Martin Hewison, Roger Bouillon, Edward Giovannucci, David Goltzman, Mark Meyer, JoEllen Welsh (eds.). Academic Press, Page: 341-357, Jan 2024.
1b2 McCormack SE, Wang Z, Wade KL, Dedio A, Cilenti N, Crowley J, Plessow F, Bamba V, Roizen JD, Jiang Y, Stylli J, Ramakrishnan A, Platt ML, Shekdar K, Fisher MJ, Vetter VL, Hocking M, Xiao R, Lawson EA.: A Pilot Randomized Clinical Trial of Intranasal Oxytocin to Promote Weight Loss in Individuals With Hypothalamic Obesity. J Endocr Soc 7(1): bvad037, Mar 2023.
12f Qu HQ, Qu J, Glessner J, Liu Y, Mentch F, Chang X, March M, Li J, Roizen JD, Connolly JJ, Sleiman P, Hakonarson H.: Improved genetic risk scoring algorithm for type 1 diabetes prediction. Pediatr Diabetes 23(3): 320-323, May 2022.
14b Qu HQ, Qu J, Bradfield J, Glessner J, Chang X, March M, Mentch FD, Roizen JD, Connolly JJ, Sleiman P, Hakonarson H.: Combined Application of Genetic and Polygenic Risk Score for Type 1 Diabetes Risk Prediction. Diabetes Obes Metab 23(8): 2001-2003, Aug 2021.
104 Mancilla EE, Zielonka B, Roizen JD, Dodds KM, Rand EB, Heimall JR, Chen F, Wu C, Goldberg DJ, Rychik J.: Growth in Children with a Fontan Circulation. J Pediatr 235(1): 149-155, Aug 2021.
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