Kyong-Mi Chang, M.D.

faculty photo
Associate Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
A424, Medical Research Building
Philadelphia VA Medical Center
University and Woodland Ave
Philadelphia, PA 19104
Office: (215) 823-5893
Fax: (215) 823-4394
Lab: (215) 823-5800 ext 6730
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
The Medical College of Pennsylvania, 1987.
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Description of Research Expertise

- immune mechanisms of viral persistence and liver disease progression in patients infected with hepatitis C virus (HCV) and hepatitis B virus (HBV)
-high dimensional single cell immune analysis through Mass Cytometry using CyTOF2, examining 30-40 parameters at a single cell level.
-emerging expertise in genetic analysis of cardiometabolic diseases with extension to other organs (e.g. liver) using the VA Million Veterans Program (MVP) genetic and clinical databases

Selected Publications

Park J., DK Wong, AS Wahed, WM Lee, JJ. Feld JJ, N Terrault N, M Khalili, RK. Sterling, KV KowdleY, N Bzowej N, DT. Lau, WR Kim WR, C SmitH, RL Carithers, KW Torrey , JW Keith, DL Levine, D Traum, S Ho, ME Valiga, GS. Johnson, E Doo, ASF. Lok, and KM Chang. : HBV-specific and global T-cell dysfunction in chronic hepatitis B. Gastroenterology 150(3): 684-695, March 2016.

Terrault NA, Bzowej NH, Chang KM, Hwang JP, Jonas MM, Murad MH: AASLD guidelines for treatment of chronic hepatitis B. Hepatology 63(1): 261-83, January 2016.

Liang TJ, Block TM, McMahon BJ, Ghany MG, Urban S, Guo JT, Locarnini S, Zoulim F, Chang KM, Lok AS: Present and future therapies of hepatitis B: From discovery to cure. Hepatology 62(6): 1893-908, December 2015.

Khalili M, Lombardero M, Chung RT, Terrault NA, Ghany MG, Kim WR, Lau D, Lisker-Melman M, Sanyal A, Lok AS; HBRN. Collaborators (33) Roberts LR, Smith CI, Di Bisceglie AM, Brunt EM, Janssen HL, Wong DK, Juan J, Feld J, Yim C, Heathcote J, Lee WM, Perrillo R, Do S, Han SH, Tran TT, Cooper SL, Fontana RJ, Tsai N, Fried MW, Patel K, Evon D, Carithers RC, Shuhart M, Kowdley KV, Wang CC, Sterling RK, Liang TJ, Chang KM, Park JJ, Belle S, Wahed A, Cloonan Y, Kleiner D.: Diabetes and prediabetes in patients with hepatitis B residing in North America. Hepatology 62(5): 1364-74, November 2015 Notes: (cited among the collaborators).

Terrault NA, Bzowej NH, Chang KM, Hwang JP, Jonas MM, Murad MH: AASLD guidelines for treatment of chronic hepatitis B. Hepatology Epub, November 2015.

Ogdie A, Pang WG, Forde KA, Samir BD, Mulugeta L, Chang KM, Kaplan DE, Amorosa VK, Kostman JR, Reddy RK, Schumacher RH, Lo Re V 3rd.: Prevalence and risk factors for patient-reported joint pain among patients with HIV/Hepatitis C coinfection, Hepatitis C monoinfection, and HIV monoinfection. BMC Musculoskelet Disord 16(93), April 2015.

Ghany M, Perrillo R, Li R, Belle SH, Janssen HL, Terrault NA, Shuhart MC, Lau DT, Kim WR, Fried MW, Sterling RK, Di Bisceglie AM, Han SH, Ganova-Raeva LM, Chang KM, Suk-Fong Lok A : Characteristics of Adults in the Hepatitis B Research Network in North America Reflect Their Country of Origin and HBV Genotype. Clin Gastroenterol Hepatol July 2014.

Cho HS, M Kikuchi, Y Li, N Nakamoto, V Amorosa, ME Valiga, KM Chang: Induction of multiple immune regulatory pathways with differential impact in HCV/HIV coinfection. Frontiers in Immunology July 2014.

Bunchorntavakul C, Jones LM, Kikuchi M, Valiga ME, Kaplan DE, Nunes FA, Aytaman A, Reddy KR, KM Chang: Distinct Features in Natural History and Outcomes of Acute Hepatitis C. J. Clin. Gastroenterol Jan 2014.

Hafkin JS, MK Osborn, AR Localio, VK Amorosa, JR Kostmay, JJ Stern, P De La Torre, K Mounzer, I Frank, R Gross, K-M Chang, V. LoRe III: Incidence and risk factors for incomplete HBV DNA suppression in HIV/HBV-co-infected patients initiating tenofovir-based therapy. J. Viral Hepatitis Jul 2013.

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Last updated: 02/27/2016
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