Faculty

Kyong-Mi Chang, MD

faculty photo
Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Corporal Michael J. Crescenz VA Medical Center
Medical Research Building A424
3900 Woodland Avenue
Philadelphia, PA 19104
Office: (215) 823-5893
Lab: (215) 823-5800 ext 6730
Education:
A.B. (Chemistry, Mathematics, and Fine Arts)
Bryn Mawr College, 1983.
M.D.
The Medical College of Pennsylvania, 1987.
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Description of Research Expertise

Dr. Chang's research expertise is in immune mechanisms of viral persistence and disease pathogenesis with a focus on human hepatitis C and B viruses, +/- HIV confection--using high-dimensional single cell immune analysis via Flow and Mass Cytometry. As the Co-PI of a VA-funded genetic study of cardiometabolic diseases using the VA's Million Veterans Program (MVP), Dr. Chang is also examining the genetic basis of cardio metabolic disorders including NAFLD using big data involving clinical and genetic data. Since 2020, Dr. Chang has actively engaged in research involving COVID-19 given her expertise in clinical research as well as virology/immune pathogenesis.

Description of Clinical Expertise

Dr. Chang's clinical area of expertise is in the evaluation, treatment and study of patients with acute and chronic viral hepatitis B and C, with and without HIV coinfection. She established and directed the active GI/Liver clinic at the Philadelphia VA Medical Center in 1999-2012. She continues to supervise GI fellows and rotating students/residents in the GI/Liver clinic to date.

Description of Other Expertise

Dr. Chang is the Associate Chief of Research (ACOS/R&D) and Associate Dean for Research at the Philadelphia Corporal Michael J Crescenz VA Medical Center (CMCVAMC), which is academically affiliated with the University of Pennsylvania. As such, Dr. Chang has the administrative oversight in developing VA-based and/or VA-funded research (e.g. via VA Career Development Award, VA Merit Review, Cooperative Studies Program and MVP research). She is also committed to mentoring VA-based researchers both locally and nationally.

Selected Publications

Sarah E Graham, Shoa L Clarke,‡, Kuan-Han H Wu‡, Stavroula Kanoni‡, Greg JM Zajac‡, Shweta Ramdas‡, Ida Surakka, Ioanna Ntalla, Sailaja Vedantam Thomas W Winkler, Adam E Locke, Eirini Marouli, Mi Yeong Hwang, Sohee Han, Akira Narita, Ananyo Choudhury, Amy R Bentley, Kenneth Ekoru, Anurag Verma, Bhavi Trivedi, Hilary C Martin, Karen A Hunt, Qin Hui Derek Klarin, Xiang Zhu Gudmar Thorleifsson, Anna Helgadottir, Daniel F Gudbjartsson Hilma Holm, Isleifur Olafsson, Masato Akiyama Saori Sakaue, Chikashi Terao, Masahiro Kanai, Wei Zhou, Ben M Brumpton, Humaira Rasheed Sanni E Ruotsalainen, Aki S Havulinna Yogasudha Veturi, QiPing Feng, Elisabeth A Rosenthal, Todd Lingren, Jennifer Allen Pacheco, Sarah A Pendergrass, Jeffrey Haessler, Franco Giulianini, Yuki Bradford, Jason E Miller, Archie Campbell Kuang Lin, Iona Y Millwood George Hindy, Asif Rasheed, Jessica D Faul, Wei Zhao, David R Weir, Constance Turman, Hongyan Huang, Mariaelisa Graff, Anubha Mahajan#, Michael R Brown, Weihua Zhang, Ketian Yu, Ellen M Schmidt, Anita Pandit, Stefan Gustafsson, Xianyong Yin, Jian'an Luan, Jing-Hua Zhao, Fumihiko Matsuda, Hye-Mi Jang, Kyungheon Yoon, Carolina Medina-Gomez Achilleas Pitsillides, Jouke Jan Hottenga Gonneke Willemsen Andrew R Wood, Yingji Ji, Zishan Gao, Simon Haworth Ruth E Mitchell Jin Fang Chai, Mette Aadahl, Jie Yao, Ani Manichaikul, Helen R Warren Julia Ramirez, Jette Bork-Jensen, Line L Kårhus, Anuj Goel Maria Sabater-Lleal Raymond Noordam, Carlo Sidore, Edoardo Fiorillo, Aaron F McDaid Pedro Marques-Vidal, Matthias Wielscher, Stella Trompet Naveed Sattar, Line T Møllehave, Betina H Thuesen, Matthias Munz, Lingyao Zeng Jianfeng Huang, Bin Yang, Alaitz Poveda, Azra Kurbasic, Claudia Lamina, Lukas Forer, Markus Scholz Tessel E. Galesloot, Jonathan P. Bradfield, E Warwick Daw, Joseph M Zmuda, Jonathan S Mitchell, Christian Fuchsberger, Henry Christensen, Jennifer A Brody, Mary F Feitosa, Mary K Wojczynski, Michael Preuss, Massimo Mangino Paraskevi Christofidou, Niek Verweij, Jan W Benjamins, Jorgen Engmann Rachel L Kember, Roderick C Slieker Ken Sin Lo, Nuno R Zilhao, Phuong Le, Marcus E Kleber Graciela E Delgado, Shaofeng Huo, Daisuke D Ikeda, Hiroyuki Iha, Jian Yang Jun Liu, Hampton L Leonard Jonathan Marten, Börge Schmidt, Marina Arendt Laura J Smyth, Marisa Cañadas-Garre, Chaolong Wang Masahiro Nakatochi, Andrew Wong, Nina Hutri-Kähönen Xueling Sim, Rui Xia, Alicia Huerta-Chagoya, Juan Carlos Fernandez-Lopez, Valeriya Lyssenko Meraj Ahmed, Anne U Jackson, Marguerite R Irvin, Christopher Oldmeadow, Han-Na Kim Seungho Ryu Paul RHJ Timmers Liubov Arbeeva, Rajkumar Dorajoo, Leslie A Lange, Xiaoran Chai Gauri Prasad Laura Lorés-Motta, Marc Pauper, Jirong Long, Xiaohui Li, Elizabeth Theusch, Fumihiko Takeuchi, Cassandra N Spracklen Anu Loukola, Sailalitha Bollepalli, Sophie C Warner Ya Xing Wang, Wen B. Wei, Teresa Nutile, Daniela Ruggiero Yun Ju Sung, Yi-Jen Hung, Shufeng Chen, Fangchao Liu, Jingyun Yang Katherine A Kentistou, Mathias Gorski Marco Brumat, Karina Meidtner Lawrence F Bielak, Jennifer A Smith Prashantha Hebbar, Aliki-Eleni Farmaki Edith Hofer Maoxuan Lin, Chao Xue, Jifeng Zhang, Maria Pina Concas, Simona Vaccargiu, Peter J van der Most, Niina Pitkänen Brian E Cade Jiwon Lee, Sander W. van der Laan, Kumaraswamy Naidu Chitrala, Stefan Weiss, Martina E Zimmermann, Jong Young Lee, Hyeok Sun Choi, Maria Nethander Sandra Freitag-Wolf, Lorraine Southam Nigel W Rayner Carol A Wang, Shih-Yi Lin, Jun-Sing Wang Christian Couture, Leo-Pekka Lyytikäinen Kjell Nikus Gabriel Cuellar-Partida, Henrik Vestergaard, Bertha Hildalgo, Olga Giannakopoulou, Qiuyin Cai, Morgan O Obura, Jessica van Setten, Xiaoyin Li, Karen Schwander, Natalie Terzikhan, Jae Hun Shin, Rebecca D Jackson, Alexander P Reiner, Lisa Warsinger Martin, Zhengming Chen Liming Li, Heather M Highland, Kristin L Young, Takahisa Kawaguchi, Joachim Thiery Joshua C Bis, Girish N. Nadkarni, Lenore J Launer, Huaixing Li, Mike A Nalls Olli T Raitakari, Sahoko Ichihara, Sarah H Wild, Christopher P Nelson Harry Campbell, Susanne Jäger Toru Nabika, Fahd Al-Mulla, Harri Niinikoski Peter S Braund Ivana Kolcic, Peter Kovacs, Tota Giardoglou, Tomohiro Katsuya Konain Fatima Bhatti, Dominique de Kleijn, Gert J. de Borst, Eung Kweon Kim, Hieab H.H. Adams M. Arfan Ikram, Xiaofeng Zhu, Folkert W Asselbergs, Adriaan O Kraaijeveld, Joline WJ Beulens Xiao-Ou Shu, Loukianos S Rallidis, Oluf Pedersen, Torben Hansen, Paul Mitchell, Alex W Hewitt Mika Kähönen Louis Pérusse Claude Bouchard, Anke Tönjes, Yii-Der Ida Chen, Craig E Pennell, Trevor A Mori, Wolfgang Lieb, Andre Franke, Claes Ohlsson Dan Mellström Yoon Shin Cho, Hyejin Lee, Jian-Min Yuan Woon-Puay Koh Sang Youl Rhee, Jeong-Taek Woo, Iris M Heid, Klaus J Stark, Henry Völzke, Georg Homuth, Michele K Evans, Alan B Zonderman, Ozren Polasek, Gerard Pasterkamp, Imo E Hoefer, Susan Redline Katja Pahkala, Albertine J Oldehinkel, Harold Snieder, Ginevra Biino, Reinhold Schmidt, Helena Schmidt, Y Eugene Chen, Stefania Bandinelli, George Dedoussis, Thangavel Alphonse Thanaraj, Sharon LR Kardia, Norihiro Kato, Matthias B Schulze, Giorgia Girotto Bettina Jung, Carsten A Böger, Peter K Joshi, David A Bennett Philip L De Jager Xiangfeng Lu, Vasiliki Mamakou Morris Brown Mark J Caulfield Patricia B Munroe Xiuqing Guo, Marina Ciullo Jost B. Jonas, Nilesh J Samani Daniel I. Chasman Jaakko Kaprio, Päivi Pajukanta, Teresa Tusié-Luna Carlos A Aguilar-Salinas, Linda S Adair Sonny Augustin Bechayda H. Janaka de Silva, Ananda R Wickremasinghe, Ronald M Krauss, Jer-Yuarn Wu, Wei Zheng, Anneke I den Hollander, Dwaipayan Bharadwaj Adolfo Correa, James G Wilson, Lars Lind, Chew-Kiat Heng, Amanda E Nelson Yvonne M Golightly James F Wilson Brenda Penninx Hyung-Lae Kim, John Attia Rodney J Scott D C Rao, Donna K Arnett, Mark Walker, Heikki A Koistinen, Giriraj R Chandak Chittaranjan S Yajnik, Josep M Mercader, Teresa Tusie-Luna, Carlos Aguilar-Salinas, Clicerio Gonzalez Villalpando, Lorena Orozco, Myriam Fornage E Shyong Tai Rob M van Dam Terho Lehtimäki Nish Chaturvedi, Mitsuhiro Yokota, Jianjun Liu, Dermot F Reilly, Amy Jayne McKnight, Frank Kee, Karl-Heinz Jöckel, Mark I McCarthy,#, Colin NA Palmer, Veronique Vitart, Caroline Hayward, Eleanor Simonsick, Cornelia M van Duijn, Fan Lu, Jia Qu, Haretsugu Hishigaki, Xu Lin, Winfried März, Esteban J Parra, Miguel Cruz, Vilmundur Gudnason Jean-Claude Tardif Guillaume Lettre Leen M t Hart, Petra JM Elders, Daniel J Rader, Scott M Damrauer Meena Kumari, Mika Kivimaki, Pim van der Harst, Tim D Spector, Ruth J.F. Loos Michael A Province, Bruce M Psaty Ivan Brandslund Peter P Pramstaller, Kaare Christensen, Samuli Ripatti, Elisabeth Widén, Hakon Hakonarson Struan F.A. Grant, Lambertus ALM Kiemeney, Jacqueline de Graaf, Markus Loeffler Florian Kronenberg, Dongfeng Gu Jeanette Erdmann, Heribert Schunkert Paul W Franks, Allan Linneberg J. Wouter Jukema Amit V Khera Minna Männikkö, Marjo-Riitta Jarvelin, Zoltan Kutalik Francesco Cucca Dennis O Mook-Kanamori Ko Willems van Dijk, Hugh Watkins David P Strachan, Niels Grarup, Peter Sever, Neil Poulter, Jerome I Rotter, Thomas M Dantoft, Fredrik Karpe Matt J Neville Nicholas J Timpson Ching-Yu Cheng Tien-Yin Wong Chiea Chuen Khor, Charumathi Sabanayagam Annette Peters, Christian Gieger, Andrew T Hattersley, Nancy L Pedersen, Patrik KE Magnusson, Dorret I Boomsma, Eco JC de Geus L Adrienne Cupples Joyce B.J. van Meurs Mohsen Ghanbari Penny Gordon-Larsen Wei Huang, Young Jin Kim, Yasuharu Tabara, Nicholas J Wareham, Claudia Langenberg, Eleftheria Zeggini, Johanna Kuusisto, Markku Laakso, Erik Ingelsson Goncalo Abecasis John C Chambers Jaspal S Kooner Paul S de Vries, Alanna C Morrison, Kari E. North, Martha Daviglus, Peter Kraft Nicholas G Martin, John B Whitfield, Shahid Abbas, Danish Saleheen, Robin G Walters, Michael V Holmes, Corri Black, Blair H Smith, Anne E Justice, Aris Baras, Julie E Buring Paul M Ridker Daniel I Chasman Charles Kooperberg, Wei-Qi Wei, Gail P Jarvik, Bahram Namjou, M. Geoffrey Hayes, Marylyn D Ritchie, Pekka Jousilahti, Veikko Salomaa, Kristian Hveem, Bjørn Olav Åsvold, Michiaki Kubo, Yoichiro Kamatani Yukinori Okada Yoshinori Murakami, Unnur Thorsteinsdottir Kari Stefansson Yuk-Lam Ho, Julie A Lynch Daniel Rader, Phil S Tsao, Kyong-Mi Chang Kelly Cho Christopher J O'Donnell John M Gaziano Peter Wilson Charles N Rotimi, Scott Hazelhurst Michèle Ramsay Richard C Trembath, David A van Heel, Gen Tamiya, Masayuki Yamamoto, Bong-Jo Kim, Karen L Mohlke, Timothy M Frayling, Joel N Hirschhorn, Sekar Kathiresan, VA Million Veteran Program, Global Lipids Genetics Consortium, Michael Boehnke, Pradeep Natarajan Gina M Peloso†, Christopher D Brown†, Andrew P Morris†, Themistocles L Assimes†*, Panos Deloukas,†, Yan V Sun,†, Cristen J Willer†*: The power of genetic diversity in genome-wide association studies of lipids. Nature (in press), December 2021.

Levin MG, Klarin D, Georgakis MK, Lynch J, Liao KP, Voight BF, O'Donnell CJ, Chang KM, Assimes TL, Tsao PS, Damrauer SM: A Missense Variant in the IL-6 Receptor and Protection From Peripheral Artery Disease. Circ Res 129(10): 968-970, October 2021.

Shah S, Halvorson A, McBay B, Dorn C, Wilson O, Tuteja S, Chang KM, Cho K, Hauger R, Suzuki A, Hunt C, Siew E, Matheny M, Hung A, Greevy R, Roumie C.: Proton-pump inhibitor use is not associated with severe COVID-19-related outcomes: a propensity score-weighted analysis of a national veteran cohort. Gut online ahead of print, October 2021.

Block TM, Chang KM, Guo JT: Prospects for the Global Elimination of Hepatitis B. Annu Rev Virol 8(1): 437-458, September 2021.

evin MG, Zuber V, Walker VM, Klarin D, Lynch J, Malik R, Aday AW, Bottolo L, Pradhan AD, Dichgans M, Chang KM, Rader DJ, Tsao PS, Voight BF, Gill D, Burgess S, Damrauer SM: Prioritizing the Role of Major Lipoproteins and Subfractions as Risk Factors for Peripheral Artery Disease. Circulation 144(5): 353-364, August 2021.

Daghlas I, Karhunen V, Ray D, Zuber V, Burgess S, Tsao PS, Lynch JA, Lee KM, Voight BF, Chang KM, Baker EH, Damrauer SM, Howson JMM, Vujkovic M, Gill D: Genetic Evidence for Repurposing of GLP1R (Glucagon-Like Peptide-1 Receptor) Agonists to Prevent Heart Failure. J. Am. Heart Assoc. 10(13): e020331, July 2021.

MG Levin, D. Klarin, VM Walker, D Gill, J Lynch, JN Hellwege, JM Keaton, KM Lee, TL Assimes, P Natarajan, AM Hung, T Edwards, DJ Rader, JM Gaziano, NM Davies, PS Tsao, KM Chang, BF Voight, SD Damrauer: Association Between Genetic Variation in Blood Pressure and Increased Lifetime Risk of Peripheral Artery Disease. Arterioscler Thromb Vasc Biol 41(6): 2027-2034, June 2021.

Song RJ, Ho YL, Schubert P, Park Y, Posner D, Lord EM, Costa L, Gerlovin H, Kurgansky KE, Anglin-Foote T, DuVall S, Huffman JE, Pyarajan S, Beckham JC, Chang KM, Liao KP, Djousse L, Gagnon DR, Whitbourne SB, Ramoni R, Muralidhar S, Tsao PS, O'Donnell CJ, Gaziano JM, Casas JP, Cho K: Phenome-wide association of 1809 phenotypes and COVID-19 disease progression in the Veterans Health Administration Million Veteran Program. PLoS One 16(5): e0251651, May 2021.

R. Pazoki*, M. Vujkovic*, J. Elliott, E. Evangelou, D. Gill, M. Ghanbari, PJ van der Most, R. C. Pinto, M. Wielscher, M. Farlik, V. Zuber, R.J. de Knecht, H. Nieder, A. G. Uitterlinden, Lifelines Cohort Study, J. A. Lynch, X. Jiang, S. Said, D.E. Kaplan, K. M. Lee, M. Serper, R. M. Carr, P. S. Tsao, S. R. Atkinson, A. Dehghan, I. Tzoulaki, M A. Ikram, K-H. Herzig, M-R Jarvelin, B. Z. Alizadeh, C. J. O'Donnell, D. Saleheen, B. F. Voight*, K.M. Chang*, M. R. Thurz*, P. Elliott*, and the VA Million Veteran Program: Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzyme. Nature Communications 12(1): 2579, May 2021.

D. Traum, YJ Wang, KB Schwarz, J Schug, DKH Wong, HLA Janssen, NA Terrault, M Khalili, AS Wahed, KF Murray, P Rosenthal, SC Ling, N Rodriguez-Baez, RK Sterling, DTY Lau, TM Block, MD Feldman, EE Furth, WM Lee, DE Kleiner, AS Lok, KH Kaestner, KM Chang: Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver. JCI Insight 6(7): e146883, April 2021.

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Last updated: 03/20/2022
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