Drew Weissman, M.D., Ph.D.

faculty photo
Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
522 Johnson Pavilion
Philadelphia, PA 19104-6073
Office: (215) 614-0291
Fax: (215) 349-5111
Education:
B.A., M.A. (Biochemistry/Enzymology)
Brandeis University, 1981.
M.D. Ph.D. (Immunology/Microbiology)
Boston University, 1987.
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Description of Research Expertise

Dr. Weissman's laboratory focuses on the study of RNA and innate immune system biology and the application of these findings to vaccine research and gene therapy. There are three main projects in his laboratory. The first project began through the use of mRNA encoding antigen as a delivery system to load dendritic cells to promote broad immune responses as part of a vaccine. This project has expanded to include basic studies of RNA immunogenicity and translation and the development of applications for gene therapy. The second project develops new HIV envelope immunogens that can induce broad responses and cross-reactive neutralizing antibodies. The third project continues previous studies that identified a protein found on DC, macrophages, and epithelial cells that binds HIV envelope with high affinity. The main focus of this project is testing whether this and related molecules function in vivo to promote HIV genital tract infection.

Selected Publications

Vinnard Christopher, Ravimohan Shruthi, Tamuhla Neo, Ivaturi Vijay, Pasipanodya Jotam, Srivastava Shashikant, Modongo Chawangwa, Zetola Nicola M, Weissman Drew, Gumbo Tawanda, Bisson Gregory P: Isoniazid clearance is impaired among human immunodeficiency virus/tuberculosis patients with high levels of immune activation. British journal of clinical pharmacology 83(4): 801-811, Apr 2017.

Pardi Norbert, Secreto Anthony J, Shan Xiaochuan, Debonera Fotini, Glover Joshua, Yi Yanjie, Muramatsu Hiromi, Ni Houping, Mui Barbara L, Tam Ying K, Shaheen Farida, Collman Ronald G, Karikó Katalin, Danet-Desnoyers Gwenn A, Madden Thomas D, Hope Michael J, Weissman Drew: Administration of nucleoside-modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge. Nature communications 8: 14630, Mar 2017.

Pardi Norbert, Hogan Michael J, Pelc Rebecca S, Muramatsu Hiromi, Andersen Hanne, DeMaso Christina R, Dowd Kimberly A, Sutherland Laura L, Scearce Richard M, Parks Robert, Wagner Wendeline, Granados Alex, Greenhouse Jack, Walker Michelle, Willis Elinor, Yu Jae-Sung, McGee Charles E, Sempowski Gregory D, Mui Barbara L, Tam Ying K, Huang Yan-Jang, Vanlandingham Dana, Holmes Veronica M, Balachandran Harikrishnan, Sahu Sujata, Lifton Michelle, Higgs Stephen, Hensley Scott E, Madden Thomas D, Hope Michael J, Karikó Katalin, Santra Sampa, Graham Barney S, Lewis Mark G, Pierson Theodore C, Haynes Barton F, Weissman Drew: Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination. Nature 543(7644): 248-251, Mar 2017.

Ravimohan Shruthi, Tamuhla Neo, Nfanyana Kebatshabile, Ni Houping, Steenhoff Andrew P, Gross Robert, Weissman Drew, Bisson Gregory P: Elevated pre-ART CD39+CD8+ T-cell frequency is associated with early mortality in advanced HIV/TB. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America Feb 2017.

Pardi Norbert, Weissman Drew: Measuring the Adjuvant Activity of RNA Vaccines. Methods in molecular biology (Clifton, N.J.) 1499: 143-153, 2017.

Pardi Norbert, Weissman Drew: Nucleoside Modified mRNA Vaccines for Infectious Diseases. Methods in molecular biology (Clifton, N.J.) 1499: 109-121, 2017.

Ravimohan Shruthi, Tamuhla Neo, Nfanyana Kebatshabile, Steenhoff Andrew P, Letlhogile Rona, Frank Ian, MacGregor Rob Roy, Gross Robert, Weissman Drew, Bisson Gregory P: Robust Reconstitution of Tuberculosis-Specific Polyfunctional CD4+ T-Cell Responses and Rising Systemic Interleukin 6 in Paradoxical Tuberculosis-Associated Immune Reconstitution Inflammatory Syndrome. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 62(6): 795-803, Mar 2016.

Ravimohan Shruthi, Tamuhla Neo, Kung Shiang-Ju, Nfanyana Kebatshabile, Steenhoff Andrew P, Gross Robert, Weissman Drew, Bisson Gregory P: Matrix Metalloproteinases in Tuberculosis-Immune Reconstitution Inflammatory Syndrome and Impaired Lung Function Among Advanced HIV/TB Co-infected Patients Initiating Antiretroviral Therapy. EBioMedicine 3: 100-7, Jan 2016.

Weissman D, Karikó K: mRNA: Fulfilling the Promise of Gene Therapy. Molecular therapy : the journal of the American Society of Gene Therapy 23(9): 1416-7, Sep 2015.

Castellano Laura M, Hammond Rebecca M, Holmes Veronica M, Weissman Drew, Shorter James: Epigallocatechin-3-gallate rapidly remodels PAP85-120, SEM1(45-107), and SEM2(49-107) seminal amyloid fibrils. Biology open 4(9): 1206-12, Aug 2015.

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Last updated: 07/19/2017
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