Drew Weissman, M.D., Ph.D.

faculty photo
Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
522 Johnson Pavilion
Philadelphia, PA 19104-6073
Office: (215) 614-0291
Fax: (215) 349-5111
Education:
B.A., M.A. (Biochemistry/Enzymology)
Brandeis University, 1981.
M.D. Ph.D. (Immunology/Microbiology)
Boston University, 1987.
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Description of Research Expertise

Dr. Weissman's laboratory focuses on the study of RNA and innate immune system biology and the application of these findings to vaccine research and gene therapy. There are three main projects in his laboratory. The first project began through the use of mRNA encoding antigen as a delivery system to load dendritic cells to promote broad immune responses as part of a vaccine. This project has expanded to include basic studies of RNA immunogenicity and translation and the development of applications for gene therapy. The second project develops new HIV envelope immunogens that can induce broad responses and cross-reactive neutralizing antibodies. The third project continues previous studies that identified a protein found on DC, macrophages, and epithelial cells that binds HIV envelope with high affinity. The main focus of this project is testing whether this and related molecules function in vivo to promote HIV genital tract infection.

Selected Publications

Foster Jessica B, Choudhari Namrata, Perazzelli Jessica, Storm Julie, Hofmann Ted J, Jain Payal, Storm Phillip B, Pardi Norbert, Weissman Drew, Waanders Angela J, Grupp Stephan A, Karikó Katalin, Resnick Adam C, Barrett David M: Purification of mRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response. Human gene therapy Oct 2018.

Pardi Norbert, Parkhouse Kaela, Kirkpatrick Ericka, McMahon Meagan, Zost Seth J, Mui Barbara L, Tam Ying K, Karikó Katalin, Barbosa Christopher J, Madden Thomas D, Hope Michael J, Krammer Florian, Hensley Scott E, Weissman Drew: Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies. Nature communications 9(1): 3361, Aug 2018.

Pardi Norbert, Hogan Michael J, Naradikian Martin S, Parkhouse Kaela, Cain Derek W, Jones Letitia, Moody M Anthony, Verkerke Hans P, Myles Arpita, Willis Elinor, LaBranche Celia C, Montefiori David C, Lobby Jenna L, Saunders Kevin O, Liao Hua-Xin, Korber Bette T, Sutherland Laura L, Scearce Richard M, Hraber Peter T, Tombácz István, Muramatsu Hiromi, Ni Houping, Balikov Daniel A, Li Charles, Mui Barbara L, Tam Ying K, Krammer Florian, Karikó Katalin, Polacino Patricia, Eisenlohr Laurence C, Madden Thomas D, Hope Michael J, Lewis Mark G, Lee Kelly K, Hu Shiu-Lok, Hensley Scott E, Cancro Michael P, Haynes Barton F, Weissman Drew: Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses. The Journal of experimental medicine 215(6): 1571-1588, Jun 2018.

Ravimohan Shruthi, Nfanyana Kebatshabile, Tamuhla Neo, Tiemessen Caroline T, Weissman Drew, Bisson Gregory P: Common Variation in Is Associated With Early Death and Elevated Inflammasome Biomarkers Among Advanced HIV/TB Co-infected Patients in Botswana. Open forum infectious diseases 5(5): ofy075, May 2018.

Pardi Norbert, Hogan Michael J, Porter Frederick W, Weissman Drew: mRNA vaccines - a new era in vaccinology. Nature reviews. Drug discovery 17(4): 261-279, Apr 2018.

Ravimohan Shruthi, Kornfeld Hardy, Weissman Drew, Bisson Gregory P: Tuberculosis and lung damage: from epidemiology to pathophysiology. European respiratory review : an official journal of the European Respiratory Society 27(147), Mar 2018.

Norbert Pardi, Michael J. Hogan, Martin S. Naradikian, Kaela Parkhouse, Derek W. Cain, Letitia Jones, M. Anthony Moody, Hans P. Verkerke, Arpita Myles, David C. Montefiori, Jenna L. Lobby, Kevin O. Saunders, Hua-Xin Liao, Bette T. Korber, Laura L. Sutherland, Richard M. Scearce, Peter T. Hraber, Hiromi Muramatsu, Houping Ni, Daniel A. Balikov, Charles Lee, Barbara L. Mui, Ying K. Tam, Florian Krammer, Katalin Karikó, Laurence C. Eisenlohr, Thomas D. Madden, Michael J. Hope, Mark G. Lewis, Kelly K. Lee, Scott E. Hensley, Michael P. Cancro, Barton F. Haynes and Drew Weissman: Nucleoside-modified mRNA immunization elicits potent T follicular helper cell responses. Journal of Experimental Medicine i, 2018.

Hogan Michael J, Conde-Motter Angela, Jordan Andrea P O, Yang Lifei, Cleveland Brad, Guo Wenjin, Romano Josephine, Ni Houping, Pardi Norbert, LaBranche Celia C, Montefiori David C, Hu Shiu-Lok, Hoxie James A, Weissman Drew: Increased surface expression of HIV-1 envelope is associated with improved antibody response in vaccinia prime/protein boost immunization. Virology 514: 106-117, 01 2018.

Vinnard C, Ravimohan S, Tamuhla N, Pasipanodya J, Srivastava S, Modongo C, Zetola NM, Weissman D, Gumbo T, Bisson GP: Markers of gut dysfunction do not explain low rifampicin bioavailability in HIV-associated TB. J Antimicrob Chemother 72(7): 2020-2027, Jul 2017.

Vinnard C, Ravimohan S, Tamuhla N, Ivaturi V, Pasipanodya J, Srivastava S, Modongo C, Zetola NM, Weissman D, Gumbo T, Bisson GP: Isoniazid clearance is impaired among human immunodeficiency virus/tuberculosis patients with high levels of immune activation. Br j clin pharmacol 83(4): 801-811, Apr 2017.

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Last updated: 10/07/2018
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