Faculty

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Xiaowei Xu, MD, PhD

Founders Professor in Pathology and Laboratory Medicine

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Department: Pathology and Laboratory Medicine

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1f Graduate Group Affiliations 8

46 Contact information
54

Hospital of University of Pennsylvania
32 Dept. of Pathology and Laboratory Medicine
3b 6 Founders Pavilion
Philadelphia, PA 19104-4283

2e Office: 215-662-6503
32 Fax: 215-349-5910
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Email:
xug@pennmedicine.upenn.edu

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13 Education:
21 7 MD 15 (Medicine) c
4d Fudan University School of Medicine, Shanghai, China, 1992.
21 8 PhD 19 (Pharmacology) c
55 Wake Forest University School of Medicine, Winston-Salem, NC, 1996.
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Links
7a Website
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5 3 3 90 Permanent link
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b6 > Perelman School of Medicine > Faculty > Details a

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Description of Research Expertise

85 Develop CAR gamma delta T cell and extracellular vesicle-based immunotherapies for melanoma and other skin conditions
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Description of Clinical Expertise

43 Dermatopathology, pigmented lesions, and vasculitis
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Selected Publications

158 Wang H, Liu S, Sinha P, Liu F, Zhang X, Guo Y, Goncalves B, Zheng Q, Mou H, Yang J, Huang L, Miao F, Zeng T, Karakousis G, Huang AC, Mitchell T, Amaravadi R, Schuchter L, Milone M, Guo W, June C, Herlyn M, Fan Y, Xu X.: DR5 CAR-T cells target melanoma and suppress MDSCs with minimal toxicity. 3f Mol Ther. 2025 Online ahead of print.

115 Guo Y, Wang H, Liu S, Zhang X, Zhu X, Huang L, Zhong W, Guan L, Chen Y, Xiao M, Ou L, Yang J, Chen X, Huang AC, Mitchell T, Amaravadi R, Karakousis G, Miura J, Schuchter L, Flowers A, Zheng Q, Mou H, Gimotty P, Herlyn M, Guo W, Xu X. 86 : Engineered extracellular vesicles with DR5 agonistic scFvs simultaneously target tumor and immunosuppressive stromal cells. 39 Sci Adv. 11(3): eadp9009, 2025.

1ae Chen G, Huang AC, Zhang W, Zhang G, Wu M, Xu W, Yu Z, Yang J, Wang B, Sun H, Xia H, Man Q, Zhong W, Antelo LF, Wu B, Xiong X, Liu X, Guan L, Li T, Liu S, Yang R, Lu Y, Dong L, McGettigan S, Somasundaram R,Radhakrishnan R, Mills G, Lu Y, Kim J, Chen YH, Dong H, Zhao Y, Karakousis GC, Gangadhar TC, Schuchter LM, Herlyn M, Wherry EJ, Xu X,* Guo W*. * indicates co-corresponding authors 2 b6 : Exosomal PD-L1 Mediates Tumor Immunosuppression and is Associated with Patient Response to anti-PD-1 Immunotherapy. Nature 560(7718): 382-386, 2018.

1a4 Lu H, Liu S, Zhang G, Bin Wu, Zhu Y, Frederick DT, Hu Y, Zhong W, Randell S, Sadek N, Zhang W, Chen G, Cheng C, Zeng J, Wu LW, Zhang J, Liu X, Xu W, Krepler C, Sproesser K, Xiao M, Miao B, Liu J, Song CD, Liu JY, Karakousis GC, Schuchter LM, Lu Y, Mills G, Cong Y, Chernoff J, Guo J, Boland GM, Sullivan RJ, Wei Z, Field J, Amaravadi RK, Flaherty KT, Herlyn M*, Xu X*, Guo W*. cd *Herlyn, Xu and Guo are co-corresponding authors.: PAK Signaling Drives Acquired Drug Resistance to MAPK Inhibitors in BRAFmutant Melanomas. Nature 550(7674): 133-136, 2017

f4 Ou L, Liu S, Wang H, Guo Y, Guan L, Shen L, Luo R, Elder DE, Huang AC, Karakousis G, Miura J, Mitchell T, Schuchter L, Amaravadi R, Flowers A, Mou H, Yi F, Guo W, Ko J, Chen Q, Tian B, Herlyn M, Xu X. 61 : Patient-derived melanoma organoid models facilitate the assessment of immunotherapies. 3a EBioMedicine. (92), 104614, 2023

fe Wang H, Chen H, Liu S, Zhang J, Lu H, Somasundaram R, Choi R, Zhang G, Ou L, Scholler J, Tian S, Dong L, Yeye G, Huang L, Connelly T, Li L, Huang A, Mitchell TC, Fan Y, June CH, Mills GB, Guo W, Herlyn M, Xu X. 83 : Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function. 43 J Immunother Cancer. 9(12): e003339, 2021.

133 Liu S, Zhang G, Guo J, Chen X, Lei J, Ze K, Dong L, Dai X, Song D, Ecker B, Yang R, Feltcher C, Peng K, Feng C, Chen H, Lee RX, Kerestes H, Niu J, Kumar S, Xu W, Zhang J, Wei Z, Martin JS, Liu X, Mills G, Lu Y, Guo W, Weeraratna A, Herlyn M, Wei W, Lee FS, Xu X 80 : Loss of Phd2 Cooperates with BRAFV600E to Drive Melanomagenesis. Nat Commun. 9(1): 5426, 2018

1ac Fane ME, Chhabra Y, Alicea GM, Maranto DA, Douglass SM, Webster MR, Rebecca VW, Marino GE, Almeida F, Ecker BL, Zabransky DJ, Hüser L, Beer T, Tang HY, Kossenkov A, Herlyn M, Speicher DW, Xu W, Xu X, Jaffee EM, Aguirre-Ghiso JA, Weeraratna AT.: Stromal changes in the aged lung induce an emergence from melanoma dormancy. Nature 606(7913): 396-405, 2022.

1ba Khan O, Giles JR, McDonald S, Manne S, Ngiow SF, Patel KP, Werner MT, Huang AC, Alexander KA, Wu JE, Attanasio J, Yan P, George SM, Bengsch B, Staupe RP, Donahue G, Xu W, Amaravadi RK, Xu X, Karakousis GC, Mitchell TC, Schuchter LM, Kaye J, Berger SL, Wherry EJ: TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion. Nature 571(7764): 211-218, 2019.

24c Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, Cho H, Spevak W, Zhang C, Zhang Y, Habets G, Burton B, West BL, Powell B, Shellooe R, Marimuthu A, Nguyen H, Zhang KYJ, Artis DR, Schlessinger J, Su F, Higgins B, Iyer R, D’Andrea K, Koehler A, Stumm M, Lee RJ, Grippo J, Puzanov I, Kim KB, Ribas A, McArthur GA, Sosman JA, Chapman PB, Flaherty KT, Xu X, Nathanson KL, Nolop K: Clinical efficacy of a RAF inhibitor requires comprehensive ERK pathway inhibition in BRAF-mutant melanoma. Nature 467(7315): 596-9, 2010

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