Roddy O'Connor, B.Sc., M.S., Ph.D.

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Research Assistant Professor of Pathology and Laboratory Medicine
Department: Pathology and Laboratory Medicine
Graduate Group Affiliations

Contact information
3400 Civic Center Blvd
8-105 SPE
Perelman School of Medicine
Philadelphia, PA 19104
B.Sc. (Exercise Physiology)
University of Limerick, 1997.
M.S. (Clinical Exercise Physiology)
Georgia State University, 1999.
Ph.D. (Molecular Pharmacology)
Emory University School of Medicine, 2007.
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Description of Research Expertise

CAR-T cell metabolism; T cell activation, proliferation and differentiation; Lentiviral, retroviral and mRNA-based gene transfer; Post-transcriptional gene suppression by shRNA and microRNA's; Bio-engineered cell culture platforms; Tissue stem cell differentiation;

Description of Clinical Expertise

Clinical Research Coordinator

Description of Other Expertise

Biomedical Expert (Local News Affiliate)

Selected Publications

Durgin JS, Thokala R, Johnson L, Song E, Leferovich J, Bhoj V, Ghassemi S, Milone M, Binder Z, O'Rourke DM, O'Connor RS.: Enhancing CAR T Function with the Engineered Secretion of C. Perfringens Neuraminidase. Mol Ther Nov 2021.

Mohamed FA, Thangavelu G, Rhee SY, Sage PT, O'Connor RS, Rathmell JC, Blazar BR.: Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease. Front Immunol 12: 757836, Oct 2021.

Garcia-Canaveras JC, Heo D, Trefely S, Leferovich J, Xu C, Philipson BI, Ghassemi S, Milone MC, Moon EK, Snyder NW, June CH, Rabinowitz JD, O'Connor RS.: CAR T-Cells Depend on the Coupling of NADH Oxidation with ATP Production. Cells 10: 2334, Sep 2021.

Tu VY, Ayari A, O'Connor RS.: Beyond the Lactate Paradox: How Lactate and Acidity Impact T Cell Therapies against Cancer. Antibodies (Basel) 10: 25, Jun 2021.

Durgin JS, Henderson F Jr, Nasrallah MP, Mohan S, Wang S, Lacey SF, Melenhorst JJ, Desai AS, Lee JYK, Maus MV, June CH, Brem S, O'Connor RS, Binder Z, O'Rourke DM.: Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma. Front Oncol 11: 669071, May 2021.

Rodriguez-Garcia A, Lynn RC, Poussin M, Eiva MA, Shaw LC, O'Connor RS, Minutolo NG, Casado-Medrano V, Lopez G, Matsuyama T, Powell DJ Jr.: CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy. Nat Commun 12: 877, Feb 2021.

Safarzadeh Kozani P, Safarzadeh Kozani P, O'Connor RS.: In Like a Lamb; Out Like a Lion: Marching CAR T Cells Toward Enhanced Efficacy in B-ALL. Mol Cancer Ther 2021.

Sellmyer, M.A., Richman, S.A., Lohith, K., Hou, C., Weng, C-C, Mach, R.H., O'Connor, R.S., Milone, M.C., and Farwell, M.D.: Imaging CAR T Cell Trafficking with eDFHR as a PET Reporter Gene Molecular Therapy 2020.

Klichinsky, M., Ruella, M., Shestova, O., Lu, X. M., Best, A., Zeeman, M., Schmierer, M., Gabrusiewicz, K., Anderson, N. R., Petty, N. E., Cummins, K. D., Shen, F., Shan, X., Veliz, K., Blouch, K., Yashiro-Ohtani, Y., Kenderian, S. S., Kim, M. Y., O'Connor, R. S., Wallace, S. R., Kozlowski, M. S., Marchione, D. M., Shestov, M., Garcia, B. A., June, C. H., Gill, S.: Human chimeric antigen receptor macrophages for cancer immunotherapy. Nat Biotechnol 38(8): 947-953, 2020.

O'Connor, R.S. and Milone, M.C.: Testing the Specificity of Compounds Designed to Inhibit CPT1A in T cells. Methods Molecular Biology 2097, 2020.

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Last updated: 12/07/2021
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