Jeffrey David Roizen, M.D., Ph.D.

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Assistant Professor of Pediatrics
Department: Pediatrics
Graduate Group Affiliations

Contact information
The Children's Hospital of Philadelphia
3401 Civic Center Blvd.
Division of Endocrinology and Diabetes
11th Floor/NWT/Suite 30
Philadelphia, PA 19104
Office: 215-590-3174
Fax: 215-590-3053
Lab: 267 678 3597
BA (Chemistry and Biology (double major))
Williams College, Williamstown, MA, 2000.
Washington university School of Medicine, St. Louis, MO, 2008.
PhD (Molecular and Cell Biology)
Washington University School of Medicine, St. Louis, MO, 2008.
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Description of Research Expertise

The goal of our laboratory is to understand non-calciometabolic effects of vitamin D and to use this understanding to design new therapeutic approaches to common diseases such as sarcopenia and obesity. Towards this goal we employ a uniquely diverse toolbox of methods using large human data sets and mouse physiology combined with high throughput sequencing to drive questions in cell culture and results from unbiased screening in cell culture to drive test-of-principle experiments and trials in mice and humans. Additionally, we rely on core principles of improv (“LISTEN” (to your collagues and to the data), say “yes, and…” (if you encounter a fact that doesn’t fit your theory, follow the fact), “find the game” (what is interesting, can you set up your Qs so that any answer is interesting), “If this is true, then what else is true…” (if you find something interesting, does it imply other interesting things), “there are no mistakes” (for well designed experiments, there are no failures)) to drive our science.

Selected Publications

Pandey Rahul, Bakay Marina, Hain Heather S, Strenkowski Bryan, Elsaqa Barakat Z B, Roizen Jeffrey D, Kushner Jake A, Orange Jordan S, Hakonarson Hakon: CLEC16A regulates splenocyte and NK cell function in part through MEK signaling. PloS one 13(9): e0203952, September 2018.

Roizen Jeffrey D, Casella Alex, Lai Meizan, Long Caela, Tara Zahra, Caplan Ilana, O'Lear Lauren, Levine Michael A: Decreased Serum 25-Hydroxyvitamin D in Aging Male Mice Is Associated With Reduced Hepatic Cyp2r1 Abundance. Endocrinology 159(8): 3083-3089, Aug 2018.

Roizen JD, Li D, O'Lear L, Javaid MK, Shaw NJ, Ebeling PR, Nguyen HH, Rodda CP, Thummel KE, Thacher TD, Hakonarson H, Levine MA.: CYP3A4 mutation causes vitamin D-dependent rickets type 3. Journal of Clinical Investigation Feb 2018 Notes: doi: 10.1172/JCI98680.

Hong J, Hatchell KE, Bradfield JP, Andrew B, Alessandra C, Chao-Qiang L, Langefeld CD, Lu L, Lu Y, Lutsey PL, Musani SK, Nalls MA, Robinson-Cohen C, Roizen JD, Saxena R, Tucker KL, Ziegler JT, Arking DE, Bis JC, Boerwinkle E, Bottinger EP, Bowden DW, Gilsanz V, Houston DK, Kalkwarf HJ, Kelly A, Lappe JM, Liu Y, Michos ED, Oberfield SE, Palmer ND, Rotter JI, Sapkota B, Shepherd JA, Wilson JG, Basu S, de Boer IH, Divers J, Freedman BI, Grant SFA, Hakanarson H, Harris TB, Kestenbaum BR, Kritchevsky SB, Loos RJF, Norris JM, Norwood AF, Ordovas JM, Pankow JS, Psaty BM, Sanhgera DK, Wagenknecht LE, Zemel BS, Meigs J, Dupuis J, Florez JC, Wang T, Liu CT, Engelman CD, Billings LK.: Trans-ethnic Evaluation Identifies Novel Low Frequency Loci Associated with 25-Hydroxyvitamin D Concentrations. J Clin Endocrinol Metab. (eds.). Jan 2018 Notes: doi: 10.1210/jc.2017-01802. [Epub ahead of print]

Roizen JD, Palladino A.: Chapter 72: Disorders of the Adrenal Gland. Comprehensive Pediatric Hospital Medicine, Second Edition. Zaoutis L, Chiang VW. (eds.). Page: 336-41, Dec 2017.

Roizen MD, Roizen JD: Chapter 11: The Role of Exercise in Integrative Preventive Medicine. Integrative Preventive Medicine. Carmona RH, Liponis M. (eds.). Oxford University Press, Page: 206-26, Dec 2017 Notes: DOI: 10.1093/med/9780190241254.001.000.

Fleisher LA, Roizen MF, Roizen JD. : Essence of Anesthesia Practice, 4th Edition. Elsevier. Fleisher LA, Roizen MF, Roizen JD eds. (eds.). Elsevier, July 2017.

Xi D, Long C, Lai M, Casella A, O’Lear L, Kublaoui B, Roizen JD: Ablation of oxytocin neurons causes a deficit in cold stress response. J. Endocr. Soc. 1(7), July 2017 Notes: doi: 10.1210/js.2017-00136.

Roizen, JD*, Hysinger EB*, Mentch, F, Connolly, J, Bradfield, JP, Almoguera, B, Allen, J, Levine, MA, Hakonarson, H. : The Causal Relationship of Vitamin D and Asthma: A Cross-sectional and Mendelian Randomization Analysis. Journal of Allergy and Clinical Immunology 138(6): 1747-1749, Dec 2016 Notes: *co-first authors.

Mancilla E, Zielonka, B, Brodsky J, Roizen J, Zemmel B, Goldberg DJ, Dodds KM, Rychik J. : Growth Parameters, Bone Mineral Density and Secondary Hyperparathyroidism After Fontan Operation: Results from the Multidisciplinary Clinic at the CHOP Single Ventricle Survivorship Program. American Heart Association Annual Meeting November 2016.

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Last updated: 10/28/2018
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