David M Merrick, MD, PhD

faculty photo
Assistant Professor of Medicine
Department: Medicine
Graduate Group Affiliations

Contact information
Institute for Diabetes, Obesity and Metabolism
Smilow Center for Translational Research, 12th Floor, Room 179
3400 Civic Center Boulevard
Philadelphia, PA 19104
Office: 203-209-1070
Lab: 215-746-0551
B.S. (Cellular Biology)
Johns Hopkins University, 2004.
MD (Internal Medicine)
Yale School of Medicine, 2013.
PhD (Cell Biology)
Yale School of Medicine, 2013.
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Description of Clinical Expertise

Medical Management of Obesity

Selected Publications

Merrick David, Sakers Alexander, Irgebay Zhazira, Okada Chihiro, Calvert Catherine, Morley Michael P, Percec Ivona, Seale Patrick: Identification of a mesenchymal progenitor cell hierarchy in adipose tissue. Science (New York, N.Y.) 364(6438), April 2019.

Merrick David, Mistry Kavita, Wu Jingshing, Gresko Nikolay, Baggs Julie E, Hogenesch John B, Sun Zhaoxia, Caplan Michael J: Polycystin-1 regulates bone development through an interaction with the transcriptional coactivator TAZ. Human molecular genetics 28(1): 16-30, January 2019.

Merrick D, Sakers A, Kim J, Irgebay Z, Seale P.: “Population Dynamics of Adipocyte Progenitors.” Kroc Lecture, (2018 and 2019)University of Pennsylvania, Perelman School of Medicine and Department of Medicine Research Day, University of Pennsylvania, June 2018 March 2018 Notes: Poster Presentation.

Merrick David, Bertuccio Claudia A, Chapin Hannah C, Lal Mark, Chauvet Veronique, Caplan Michael J: Polycystin-1 cleavage and the regulation of transcriptional pathways. Pediatric nephrology (Berlin, Germany) 29(4): 505-11, Apr 2014.

Merrick David, Chapin Hannah, Baggs Julie E, Yu Zhiheng, Somlo Stefan, Sun Zhaoxia, Hogenesch John B, Caplan Michael J: The γ-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism. Developmental cell 22(1): 197-210, Jan 2012.

Karihaloo Anil, Koraishy Farrukh, Huen Sarah C, Lee Yashang, Merrick David, Caplan Michael J, Somlo Stefan, Cantley Lloyd G: Macrophages promote cyst growth in polycystic kidney disease. Journal of the American Society of Nephrology : JASN 22(10): 1809-14, Oct 2011.

Lal Mark, Song Xuewen, Pluznick Jennifer L, Di Giovanni Valeria, Merrick David M, Rosenblum Norman D, Chauvet Veronique, Gottardi Cara J, Pei York, Caplan Michael J: Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling. Human molecular genetics 17(20): 3105-17, Oct 2008.

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Last updated: 04/22/2020
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