Faculty

Derek Alan Oldridge, M.D., Ph.D.

Assistant Professor of Pathology and Laboratory Medicine

Department: Pathology and Laboratory Medicine

Graduate Group Affiliations

Contact information

Children's Hospital of Philadelphia
Colket Translational Research Building Rm. 9028
3501 Civic Center Boulevard
Philadelphia, PA 19104

Email:
oldridged@chop.edu

Education:
B.A.
Reed College (Interdisciplinary Chemistry/Physics), 2007.
Ph.D.
University of Pennsylvania (Genomics and Computational Biology), 2015.
M.A.
The Wharton School at the University of Pennsylvania (Statistics), 2015.
M.D.
Perelman School of Medicine at the University of Pennsylvania, 2017.

Links
The Oldridge Lab Website

Permanent link

> Perelman School of Medicine > Faculty > Details

Description of Clinical Expertise

Histocompatibility
Immunogenetics
Molecular Pathology
Clinical Pathology

Description of Research Expertise

Bioinformatics
Cancer
Genomics
Immunology
Immunotherapy
Pediatric Oncology
Statistics

Selected Publications

Bandyopadhyay S, Duffy M, Ahn KJ, Pang M, Smith D, Duncan G, Sussman J, Zhang I, Huang J, Lin Y, Xiong B, Imtiaz T, Chen CH, Thadi A, Chen C, Xu J, Reichart M, Pillai V, Snaith O, Oldridge D, Bhattacharyya S, Maillard I, Carroll M, Nelson C, Qin L, Tan K.: Mapping the Cellular Biogeography of Human Bone Marrow Niches Using Single-Cell Transcriptomics and Proteomic Imaging. bioRxiv Mar 2024 Notes: 10.1101/2024.03.14.585083.

Sussman JH*, Oldridge DA*, Yu W*, Chen CH, Zellmer AM, Rong J, Parvaresh-Rizi A, Thadi A, Xu J, Bandyopadhyay S, Sun Y, Wu D, Hunter CE, Brosius S, Ahn KJ, Baxter AE, Koptyra MP, Vanguri RS, McGrory S, Resnick AC, Storm PB, Amankulor NM, Santi M, Viaene AN, Zhang N, Raedt T, Cole K, Tan K.: A longitudinal single-cell and spatial multiomic atlas of pediatric high-grade glioma. bioRxiv Mar 2024 Notes: doi: 10.1101/2024.03.06.583588.

Nabbi A, Beck P, Delaidelli A, Oldridge DA, Sudhaman S, Zhu K, Yang SYC, Mulder DT, Bruce JP, Paulson JN, Raman P, Zhu Y, Resnick AC, Sorensen PH, Sill M, Brabetz S, Lambo S, Malkin D, Johann PD, Kool M, Jones DTW, Pfister SM, Jäger N, Pugh TJ: Transcriptional immunogenomic analysis reveals distinct immunological clusters in paediatric nervous system tumours. Genome Med 15(1), Sep 2023 Notes: doi: 10.1186/s13073-023-01219-x.

Weichert-Leahey N, Shi H, Tao T, Oldridge DA, Durbin AD, Abraham BJ, Zimmerman MW, Zhu S, Wood AC, Reyon D, Joung JK, Young RA, Diskin SJ, Maris JM, Look AT.: Genetic predisposition to neuroblastoma results from a regulatory polymorphism that promotes the adrenergic cell state. J Clin Invest 133(10), May 2023.

Conrey PE, Denu L, O'Boyle KC, Rozich I, Green J, Maslanka J, Lubin JB, Duranova T, Haltzman BL, Gianchetti L, Oldridge DA, De Luna N, Vella LA, Allman D, Spergel JM, Tanes C, Bittinger K, Henrickson SE, Silverman MA.: IgA deficiency destabilizes homeostasis toward intestinal microbes and increases systemic immune dysregulation. Sci Immunol 8(83), May 2023 Notes: doi: 10.1126/sciimmunol.ade2335.

Le Coz C, Oldridge DA, Herati RS, De Luna N, Garifallou J, Cruz Cabrera E, Belman JP, Pueschl D, Silva LV, Knox AVC, Reid W, Yoon S, Zur KB, Handler SD, Hakonarson H, Wherry EJ, Gonzalez M, Romberg N.: Human T follicular helper clones seed the germinal center-resident regulatory pool. Sci Immunol 8(82), Apr 2023 Notes: doi: 10.1126/sciimmunol.ade8162.

Weichert-Leahey N, Shi H, Tao T, Oldridge DA, Durbin AD, Abraham BJ, Zimmerman MW, Zhu S, Wood AC, Reyon D, Joung JK, Young RA, Diskin SJ, Maris JM, Look AT.: Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State. bioRxiv Mar 2023.

Matthew E. Lee, Victoria Fang, Rami Vanguri, Abigail Zellmer, Amy Baxter, Dokyoon Kim*, Derek Oldridge*, E. John Wherry*: A multimodal image pipeline for automated generation of large, labeled H&E image datasets. MedNeurIPS 2023.

Abigail M. Zellmer, Jonathan Sussman, Amy E. Baxter, Rami S. Vanguri, Kyung Jin Ahn, Arianne Parvaresh-Rizi, Anusha Thadi, Chia-hui Chen, Wenbao Yu, Kristina Cole, Kai Tan, Derek A. Oldridge: Longitudinal spatial profiling of pediatric high-grade glioma reveals a heterogeneous and dynamic immune microenvironment with therapeutic implications. Society for Immunotherapy of Cancer (SITC) Annual Meeting 2023.

Alanio C, Verma A, Mathew D, Gouma S, Liang G, Dunn T, Oldridge DA, Weaver J, Kuri-Cervantes L, Pampena MB, Betts MR, Collman RG, Bushman FD, Meyer NJ, Hensley SE, Rader D, Wherry EJ; UPenn COVID Processing Unit: Cytomegalovirus Latent Infection is Associated with an Increased Risk of COVID-19-Related Hospitalization. J Infect Dis 226(3): 463-473, Aug 2022 Notes: doi: 10.1093/infdis/jiac020.