Jason D. Christie, MD, MSCE

faculty photo
Paul F. Harron, Jr. Family Professor
Department: Medicine

Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
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Description of Research Expertise

Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.

Selected Publications

Maria C Basil, Fabian L Cardenas-Diaz, Jaymin J Kathiriya, Michael P Morley, Justine Carl, Alexis N Brumwell, Jeremy Katzen, Katherine J Slovik, Apoorva Babu, Su Zhou, Madison M Kremp, Katherine B McCauley, Shanru Li, Joseph D Planer, Shah S Hussain, Xiaoming Liu, Rebecca Windmueller, Yun Ying, Kathleen M Stewart, Michelle Oyster, Jason D Christie, Joshua M Diamond, John F Engelhardt, Edward Cantu, Steven M Rowe, Darrell N Kotton, Harold A Chapman, Edward E Morrisey: Human distal airways contain a multipotent secretory cell that can regenerate alveoli. Nature 604: 120-126, April 2022 Notes: Epub 2022 Mar 30.

Anderson MR, Aronson KI, Diamond JM, Christie JD, Singer JP.: Current Beliefs and Practices Regarding the Management of Obesity in Patients with Progressive Interstitial Lung Disease. Ann Am Thorac Soc Apr 2022.

Mikacenic C, Bhatraju P, Robinson-Cohen C, Kosamo S, Fohner AE, Dmyterko V, Long SA, Cerosaletti K, Calfee CS, Matthay MA, Walley KR, Russell JA, Christie JD, Meyer NJ, Christiani DC, Wurfel MM.: Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness. Crit Care Med 50: e284-e293, Mar 2022.

Faust HE, Oniyide O, Wang Y, Forker CM, Dunn T, Yang W, Lanken PN, Sims CA, Yehya N, Christie JD, Meyer NJ, Reilly JP, Mangalmurti NS, Shashaty MGS.: Early Plasma Nuclear DNA, Mitochondrial DNA, and Nucleosome Concentrations Are Associated With Acute Kidney Injury in Critically Ill Trauma Patients. Crit Care Explor 4: e0663, Mar 2022.

Farrell CL, Miano TA, Griffiths S, Christie JD, Diamond JM, Shashaty MGS.: Early post-lung transplant calcineurin inhibitor management varies widely: An international survey. Clin Transplant February 2022.

McQuiston A, Scott D, Nord D, Langerude L, Pelaez A, Machuca T, Mehta A, Drake RR, Christie JD, Angel P, Atkinson C.: Pro-inflammatory IgG1 N-glycan signature correlates with primary graft dysfunction onset in COPD patients. Transpl Immunol 2022.

Tatiana Akimova, Tianyi Zhang, Lanette M Christensen, Zhonglin Wang, Rongxiang Han, Dmitry Negorev, Arabinda Samanta, Isaac E Sasson, Trivikram Gaddapara, Jing Jiao, Liqing Wang, Tricia R Bhatti, Matthew H Levine, Joshua M Diamond, Ulf H Beier, Rebecca A Simmons, Edward Cantu, David S Wilkes, David J Lederer, Michaela Anderson, Jason D Christie, Wayne W Hancock : Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury. American Journal of Respiratory and Critical Care Medicine 204(9): 1060-1074, November 2021 Notes: Online ahead of print.

Courtwright AM, Kamoun M, Diamond JM, Kearns J, Ahya VN, Christie JD, Clausen E, Hadjiliadis D, Patel N, Salgado JC, Cevasco M, Cantu EE, Crespo MM, Bermudez CA.: Lung transplantation outcomes after crossing low-level donor specific antibodies without planned augmented immunosuppression. Clin Transplant 35(11): e14447. November 2021.

Julia A Maheshwari, Nicholas A Kolaitis, Michaela R Anderson, Luke Benvenuto, Ying Gao, Patricia P Katz, John Greenland, Paul J Wolters, Kenneth Covinsky, Steven R Hays, Jasleen Kukreja, Daniel R Calabrese , Aida Venado, Rupal J Shah , Lorriana E Leard, Binh Trinh, Chiung-Yu Huang, David Glidden, Mary Ellen Kleinhenz, Jeffrey A Golden, Nicole Sutter, Gayelan Tietje-Ulrich, Rachel N Criner, Selim M Arcasoy, Jason D Christie, Joshua Diamond, Jonathan P Singer : Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates. Annuals of the American Thoracic Society 9: 1464-1474. September 2021.

Mulong Du, Joe G N Garcia, Jason D Christie, Junyi Xin, Guoshuai Cai, Nuala J Meyer, Zhaozhong Zhu, Qianyu Yuan, Zhengdong Zhang, Li Su, Sipeng Shen, Xuesi Dong , Hui Li, John N Hutchinson, Paula Tejera, Xihong Lin, Meilin Wang, Feng Chen, David C Christiani: Integrative omics provide biological and clinical insights into acute respiratory distress syndrome. Intensive Care Medicine 7: 761-771, July 2021.

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Last updated: 09/15/2022
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