Jason D. Christie, MD, MSCE

faculty photo
Paul F. Harron, Jr. Family Professor
Department: Medicine
Graduate Group Affiliations

Contact information
Division of Pulmonary and Critical Care Medicine
Hospital of the University of Pennsylvania
Center for Clinical Epidemiology and Biostatistics
University of Pennsylvania School of Medicine
423 Guardian Drive
221 Blockley Hall
Philadelphia, PA 19104
Office: (215) 573-3209
Fax: (215) 573-0198
Sc.B. (Chemistry)
Brown University, 1989.
M.D. (Medicine)
Columbia University, 1993.
M.S.C.E. (Clinical Epidemiology)
University of Pennsylvania, 2002.
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Description of Research Expertise

Dr. Christie's career is focused on translational research studies of the risks, pathogenesis, treatment, and outcomes of acute lung injury in the transplant and non-transplant human populations. His research integrates new knowledge generated from bench studies with epidemiology approaches in well-phenotyped, large human populations to generate new definitions of human syndromes, improved diagnostics and prognostics, and targeted therapy approaches in advanced lung diseases and critical illness.

Dr. Christie is the founder of the lung transplant outcomes group (LTOG), which is a multicentered cohort study the etiology and pathogenesis of acute lung injury following lung transplantation (termed primary graft dysfunction). Active LTOG research themes focus on the mechanisms of clinical factors that elevate PGD risk, including donor smoke exposure, recipient obesity and body composition, pulmonary hypertension, alterations in lung microbiome, and autoimmunity to lung collagens. His multidisciplinary lung transplant research focuses on genetics, innate immunity, regulatory T-cells, innate lymphoid cell (ILC) populations in the lung, ischemia reperfusion injury, inflammation, and autoimmunity.

Selected Publications

Jennifer C Ginestra, Oscar J L Mitchell, George L Anesi, Jason D Christie : COVID-19 Critical Illness: A Data-Driven Review. Annual Review of medicine 10.1146, September 2021.

Julia A Maheshwari, Nicholas A Kolaitis, Michaela R Anderson, Luke Benvenuto, Ying Gao, Patricia P Katz, John Greenland, Paul J Wolters, Kenneth Covinsky, Steven R Hays, Jasleen Kukreja, Daniel R Calabrese , Aida Venado, Rupal J Shah , Lorriana E Leard, Binh Trinh, Chiung-Yu Huang, David Glidden, Mary Ellen Kleinhenz, Jeffrey A Golden, Nicole Sutter, Gayelan Tietje-Ulrich, Rachel N Criner, Selim M Arcasoy, Jason D Christie, Joshua Diamond, Jonathan P Singer : Construct and Predictive Validity of Sarcopenia in Lung Transplant Candidates. Annuals of the American Thoracic Society 9: 1464-1474. September 2021.

Tatiana Akimova, Tianyi Zhang, Lanette M Christensen, Zhonglin Wang, Rongxiang Han, Dmitry Negorev, Arabinda Samanta, Isaac E Sasson, Trivikram Gaddapara, Jing Jiao, Liqing Wang, Tricia R Bhatti, Matthew H Levine, Joshua M Diamond, Ulf H Beier, Rebecca A Simmons, Edward Cantu, David S Wilkes, David J Lederer, Michaela Anderson, Jason D Christie, Wayne W Hancock : Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury. American Journal of Respiratory and Critical Care Medicine August 2021 Notes: Online ahead of print.

John E McGinniss, Samantha A Whiteside, Aurea Simon-Soro, Joshua M Diamond, Jason D Christie, Fredrick D Bushman, Ronald G Collman : The lung microbiome in lung transplantation. The Journal of Heart and Lung Transplantation 40(8): 733-744, August 2021.

Alexander McQuiston, Amir Emtiazjoo, Peggi Angel, Tiago Machuca, Jason Christie, Carl Atkinson : Set Up for Failure: Pre-Existing Autoantibodies in Lung Transplant. Frontiers in Immunology 11(12): 711102, August 2021.

Mulong Du, Joe G N Garcia, Jason D Christie, Junyi Xin, Guoshuai Cai, Nuala J Meyer, Zhaozhong Zhu, Qianyu Yuan, Zhengdong Zhang, Li Su, Sipeng Shen, Xuesi Dong , Hui Li, John N Hutchinson, Paula Tejera, Xihong Lin, Meilin Wang, Feng Chen, David C Christiani: Integrative omics provide biological and clinical insights into acute respiratory distress syndrome. Intensive Care Medicine 7: 761-771, July 2021.

Changhai Li , Kunal Patel, Zhenxiao Tu, Xiaofeng Yang, Liudmila Kulik, Ali Alawieh, Patterson Allen 4, Qi Cheng 1 2, Caroline Wallace, Jane Kilkenny, Jennie Kwon, Barry Gibney, Edward Cantu, Ashish Sharma, Mauricio Pipkin, Tiago Machuca, Amir Emtiazjoo, Martin Goddard, V Michael Holers, Satish Nadig, Jason Christie, Stephen Tomlinson, Carl Atkinson : A novel injury site-natural antibody targeted complement inhibitor protects against lung transplant injury. American Journal of Transplantation 6: 2067-2078, June 2021.

Patricia C Pawlow, Nancy P Blumenthal, Jason D Christie, Lea Ann Matura, Subhash Aryal, Mary Ersek : The Supportive Care Needs of Primary Caregivers of Lung Transplant Candidates. Journal of Pain and Symptom Management 21: 3924, May 2021 Notes: Online ahead of print.

Corrine R. Kliment,Ian J. Barbash, Jacob S. Brenner,Divay Chandra,Katherine Courtright,Marc C. Gauthier, Keven M. Robinson, Leslie P. Scheunemann, Faraaz A. Shah, Jason D. Christie, and Alison Morris: COVID-19 and the Early-Career Physician-Scientist. Fostering Resilience beyond the Pandemic. ATS Scholar Page: 19-28, March 2021.

John P. Reilly, Nuala J. Meyer,Michael G.S. Shashaty,Brian J. Anderson, Caroline Ittner,1 Thomas G. Dunn, Brian Lim,1 Caitlin Forker,1 Michael P. Bonk, Ethan Kotloff,1 Rui Feng, Edward Cantu,Nilam S. Mangalmurti,Carolyn S. Calfee, Michael A. Matthay,Carmen Mikacenic, Keith R. Walley,James Russell, David C. Christiani, Mark M. Wurfel, Paul N. Lanken,Muredach P. Reilly,and Jason D. Christie: The ABO histo-blood group, endothelial activation, and acute respiratory distress syndrome risk in critical illness. JCI The Journal of Clinical Investigation Page: 131, January 2021.

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Last updated: 10/08/2021
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