Faculty

Gui-shuang Ying, MD, PhD

faculty photo
Associate Professor of Ophthalmology at the Hospital of the University of Pennsylvania
Department: Ophthalmology
Graduate Group Affiliations

Contact information
3711 Market Street, Suite 801
Philadelphia, PA 19104
Education:
MD (Preventive Medicine)
Zhejiang Medical University, 1993.
MPH (Toxicology)
Zhejiang Medical University, 1996.
MS (Biostatistics)
University of Michigan-Ann Arbor, 2000.
PhD (Biostatistics)
University of Pennsylvania, 2004.
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Description of Research Expertise

Dr. Ying is an Associate Professor of Ophthalmology, Associate Scholar in Biostatistics, and Director of the Biostatistical Consulting Service in the Center for Preventive Ophthalmology and Biostatistics. Dr. Ying received his MD from P.R. China and Ph.D. in Biostatistics from University of Pennsylvania in 2004. Dr. Ying is the Principal Investigator or the Director of the Data Coordinating Center for several NIH-funded studies on retinopathy of prematurity (ROP), age-related macular degeneration, and the co-investigator or senior biostatistician for several NIH-funded multi-center clinical trials or observational studies. Dr. Ying collaborates with investigators for the study design, data management, statistical analysis, data interpretation and manuscript writing for the multi-center clinical studies. Dr. Ying has extensive experience in collaborating with ophthalmologists and vision researchers on conducting clinical studies for eye diseases. Dr. Ying lead his statistical team for proving biostatistical consulting service to the biomedical investigators, mostly in vision and ophthalmology community. Dr. Ying’s statistical methodologic research interest is the development of risk prediction models for eye diseases and statistical analysis for correlated data. Dr. Ying has authored and co-authored 247 papers in peer-reviewer journals.

Key words
Biostatistics consulting, prediction model, correlated data analysis

Description of Other Expertise

Biostatistical consulting, prediction in clinical trials, risk prediction models for eye diseases, statistical analysis of clustered data, statistics in diagnostic testing

Selected Publications

Vision in Preschoolers Study Group (Paulette Schmidt, Elise Ciner, Lynn Cyert, Velma Dobson, Marjean Taylor Kulp, Maureen Maguire, Bruce Moore, Deborah Orel-Bixler, Ellen Peskin, Graham Quinn, Maryann Redford, Janet Schultz, Roy Beck, Susan Cotter, Jonathan Holmes, Melvin Shipp, Sheila West, Gui-shuang Ying, Pamela Qualley, Dru Howard, Sarah Fisher, Darlene Fong, Cindy Hsiao, Selim Koseoglu, A. Mika Moy, Sharyn Shapiro, Lisa Verdon, Tonya Watson, Sara Frane, Nina Friedman, Jennifer Seino, Sean McDonnell, Erika Paez, Coriemae Perea, Darlene Sloan, Evelyn Smith, Leticia Soto, Angela Stelly-Leonard, Bruce Moore, Joanne Bolden, Sandra Uman ̃a, Justin Smith, Nicole Quinn, Nancy Carlson, Melissa Suckow, Amy Croteau, Barry Kran, Jean Ramsey, Erik Weissberg, Daniel Kurtz, Daniel Laby, Stacy Lyons, Marthedala Chery, Leticia Gonzalez, Edward Braverman, Susan Crowley, Paul Dennehy, Benny Jaramillo, Molly Biddle, Jo Haynes, Jason Hudson, Kristyne Edwards, Heather Gebhart, Ann Hickson, LeVelle Jenkins, Sandra Anderson, Nancy Evans, Jay Henry, Richard Hertle, Jeffrey Hutchinson, Andrew Toole, Michael Earley, Sherry Crawford, Kathy Reuter, Keith Johnson, Beth Haas, Tonya James, Denise Martin, Sandra Dorton, Youlanda Grace, Trina Hisle, Cheryl Jones, Betty Smith, Robert Bower, lise Ciner, Angela Duson, Lydia Parke, Mark Boas, Shannon Burgess, Penelope Copenhaven, Ellie Francis, Michael Gallaway, Janet Schwartz, Brandy Scombordi-Raghu, Janet Swiatocha, Edward Zikoski, Jennifer Lin, Sheryl Menacker, Rose Little, Geneva Moss, Jose Figueroa, Barbara Hall, Eric Nesmith, Gwen Gold, Deborah Ciner, Elizabeth Jordan, David Harvey, Linda Cheatham, Anna Chambless, Colby Beats, Debbie Coy, Jeffrey Long, Jerry Carter, Shelly Rice, James Dunn, Elisabeth Harrington, Leslie Trimble, Shelly Dreadfulwater, Cindy McCully, Rod Wyers, Edith Bingham, Vicky Taylor, Glenda Byfield, Pat Gower, Kathryn Roastingear, Elizabeth Ross, Beth Haas, Mary Brightwell-Arnold, Christine Holmes, Andrew James, Aleksandr Khvatov, Lori O’Brien, Claressa Whearry): Impact of Confidence Number on the Accuracy of SureSight Vision Screener. Optom Vis Sci 87: 96-103, 2010 Notes: Writing Team Leader.

Simonelli F, Maguire AM, Testa F ,Pierce EA, Mingozzi F, Bennicelli J, Rossi S, Marshall K, Banfi S, Surace EM, Sun J, Redmond M, Zhu X, Shindler KS, Ying GS, Ziviello C, Acerra C, Wright JF, DcDonnel JW, High KA, Bennett J, Auricchio A: Gene therapy for Leber’s congenital amaurosis is safe and effective through 1.5 years after vector administration. Molecular Therapy 18: 643-50, 2010.

Maguire AM, High KA, Auriccho A, Wright JF, Pierce EA, Testa F, Mingozzi F, Bennicelli J, Ying GS, Rossi S, Marshall KA, Banfi S, Chung D, Morgan JA, Hauck B, Zelanaia O, Zhu X, Raffini L, Coppieters F, Elfride DB, Schindler K, Volpe N, Surace EM, Acerra C, Lyubarsky A, Redmond TM, Stone E, Sun J, McDonnell JW, Leroy BP, Simonelli F, Bennett J: Phase I gene therapy shows reversal of congenital blindness: Age-dependent effect of treatment. Lancet 374: 1597-605, 2009.

Ying GS, Maguire MG, Alexander J, Martin R, Antoszyk A; Complications of Age-related Macular Degeneration Prevention Trial (CAPT) Research Group (Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL, Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Cortón M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A, Johnson RN, Ai E, McDonald HR, Stolarczuk M, Pavan PR, Billiris KK, Iyer M, Menosky MM, Pautler SE, Millard SM, Hubbard B 3rd, Aaberg T, DuBois L, Lyon A, Anderson-Nelson S, Jampol LM, Weinberg DV, Muñana A, Rozenbajgier Z, Orth D, Cohen J, MacCumber M, Figliulo C, Porcz L, Folk J, Boldt HC, Russell SR, Ivins R, Hinz CJ, Barr CC, Bloom S, Jaegers K, Kritchman B, Whittington G, Heier J, Frederick AR Jr, Morley MG, Topping T, Davis HL, Bressler SB, Bressler NM, Doll W, Trese M, Capone A, Garretson BR, Hassan TS, Ruby AJ, Ostentoski T, McCannel CA, Ruszcyzyk MJ, Grand G, Blinder K, Holekamp NM, Joseph DP, Shah G, Nobel GS, Antoszyk AN, Browning DJ, Stallings AH, Singerman LJ, Miller D, Novak M, Pendergast S, Zegarra H, Schura SA, Smith-Brewer S, Davidorf FH, Chambers R, Chorich L, Salerno J, Dreyer RF, Ma C, Kopfer MR, Klein ML, Wilson DJ, Nolte SK, Grunwald JE, Brucker AJ, Dunaief J, Fine SL, Maguire AM, Stoltz RA, McRay MN, Fish GE, Anand R, Spencer R, Arnwine J, Chandra SR, Altaweel M, Blodi B, Gottlieb J, Ip M, Nork TM, Perry-Ramond J, Fine SL, Maguire MG, Brightwell-Arnold M, Harkins S, Peskin E, Ying GS, Kurinij N): Description of the AREDS 9-step severity scale applied to participants in CAPT. Archives of Ophthalmology 127: 1147-51, 2009.

Maguire MG, Ying GS, McCannel CA, Liu C, Dai Y; Complications of Age-Related Macular Degeneration Prevention Trial(CAPT) Research Group (Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL, Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Cortón M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A, Johnson RN, Ai E, McDonald HR, Stolarczuk M, Pavan PR, Billiris KK, Iyer M, Menosky MM, Pautler SE, Millard SM, Hubbard B 3rd, Aaberg T, DuBois L, Lyon A, Anderson-Nelson S, Jampol LM, Weinberg DV, Muñana A, Rozenbajgier Z, Orth D, Cohen J, MacCumber M, Figliulo C, Porcz L, Folk J, Boldt HC, Russell SR, Ivins R, Hinz CJ, Barr CC, Bloom S, Jaegers K, Kritchman B, Whittington G, Heier J, Frederick AR Jr, Morley MG, Topping T, Davis HL, Bressler SB, Bressler NM, Doll W, Trese M, Capone A, Garretson BR, Hassan TS, Ruby AJ, Ostentoski T, McCannel CA, Ruszcyzyk MJ, Grand G, Blinder K, Holekamp NM, Joseph DP, Shah G, Nobel GS, Antoszyk AN, Browning DJ, Stallings AH, Singerman LJ, Miller D, Novak M, Pendergast S, Zegarra H, Schura SA, Smith-Brewer S, Davidorf FH, Chambers R, Chorich L, Salerno J, Dreyer RF, Ma C, Kopfer MR, Klein ML, Wilson DJ, Nolte SK, Grunwald JE, Brucker AJ, Dunaief J, Fine SL, Maguire AM, Stoltz RA, McRay MN, Fish GE, Anand R, Spencer R, Arnwine J, Chandra SR, Altaweel M, Blodi B, Gottlieb J, Ip M, Nork TM, Perry-Ramond J, Fine SL, Maguire MG, Brightwell-Arnold M, Harkins S, Peskin E, Ying GS, Kurinij N): Statin use and the incidence of advanced age-related macular degeneration in the Complications of Age-related Macular Degeneration Prevention Trial (CAPT). Ophthalmology 116: 2381-5, 2009.

Complications of Age-Related Macular Degeneration Prevention Trial Research Group (Chen W, Stambolian D, Edwards AO, Branham KE, Othman M, Jakobsdottir J, Tosakulwong N, Pericak-Vance MA, Campochiaro PA, Klein ML, Tan PL, Conley YP, Kanda A, Kopplin L, Li Y, Augustaitis KJ, Karoukis AJ, Scott WK, Agarwal A, Kovach JL, Schwartz SG, Postel EA, Brooks M, Baratz KH, Brown WL, Brucker AJ, Orlin A, Brown G, Ho A, Regillo C, Donoso L, Tian L, Kaderli B, Hadley D, Hagstrom SA, Peachey NS, Klein R, Klein BE, Gotoh N, Yamashiro K, Ferris Iii F, Fagerness JA, Reynolds R, Farrer LA, Kim IK, Miller JW, Cortón M, Carracedo A, Sanchez-Salorio M, Pugh EW, Doheny KF, Brion M, Deangelis MM, Weeks DE, Zack DJ, Chew EY, Heckenlively JR, Yoshimura N, Iyengar SK, Francis PJ, Katsanis N, Seddon JM, Haines JL, Gorin MB, Abecasis GR, Swaroop A, Johnson RN, Ai E, McDonald HR, Stolarczuk M, Pavan PR, Billiris KK, Iyer M, Menosky MM, Pautler SE, Millard SM, Hubbard B 3rd, Aaberg T, DuBois L, Lyon A, Anderson-Nelson S, Jampol LM, Weinberg DV, Muñana A, Rozenbajgier Z, Orth D, Cohen J, MacCumber M, Figliulo C, Porcz L, Folk J, Boldt HC, Russell SR, Ivins R, Hinz CJ, Barr CC, Bloom S, Jaegers K, Kritchman B, Whittington G, Heier J, Frederick AR Jr, Morley MG, Topping T, Davis HL, Bressler SB, Bressler NM, Doll W, Trese M, Capone A, Garretson BR, Hassan TS, Ruby AJ, Ostentoski T, McCannel CA, Ruszcyzyk MJ, Grand G, Blinder K, Holekamp NM, Joseph DP, Shah G, Nobel GS, Antoszyk AN, Browning DJ, Stallings AH, Singerman LJ, Miller D, Novak M, Pendergast S, Zegarra H, Schura SA, Smith-Brewer S, Davidorf FH, Chambers R, Chorich L, Salerno J, Dreyer RF, Ma C, Kopfer MR, Klein ML, Wilson DJ, Nolte SK, Grunwald JE, Brucker AJ, Dunaief J, Fine SL, Maguire AM, Stoltz RA, McRay MN, Fish GE, Anand R, Spencer R, Arnwine J, Chandra SR, Altaweel M, Blodi B, Gottlieb J, Ip M, Nork TM, Perry-Ramond J, Fine SL, Maguire MG, Brightwell-Arnold M, Harkins S, Peskin E, Ying GS, Kurinij N): Night Vision Symptoms and Progression of Age-Related Macular Degeneration in the Complications of Age-related macular degeneration Prevention Trial. Ophthalmology 115(11): 1876-1882, 2008.

Ying GS, Heitjan DF: Weibull Prediction of Event Times in Randomized Clinical Trials. Pharmaceutical Statistics 7: 107-120, 2008.

Ying GS, Heitjan DF, Chen T: Nonparametric prediction of event times in randomized clinical trials. Clinical Trials 1: 352-61, 2004.

Schenk M, Schwartz AG, O’Neal E, Kinnard M, Greenson JK, Fryzek JP, Ying GS, Garabrant DH: Familial risk of pancreas cancer. J Natl Cancer Inst 93: 640-4, 2001.

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Last updated: 02/17/2020
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